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BROOKHAVEN NATIONAL LABORATORY ASSOCIATED UNIVERSITIES. INC . Dr, Charles L, Dunirun, Dire e or DiV;,sion of Biology and Mediche In view of the fact that the hedi3 of the :.far.skLlese i s such a sens i - tive subject, we woul:! like to obtain approval for carrying out several procedures on the next survey which involve the use of small trace anorrnts of radioactive materials, Careful coasiderztion of such studies usins trace ac?te&ilS is necessary since a poJicy derision forhidding their use a t all in these people ; mulG sexiozsly c crts il future studies that may be q u i t e important both from.the point of view of th health of the people and for sae nti fic reasms, Therefore, perhaps each study should be carefully considered, weighing the merit of the study against the w se of radiation involve&. The fol loi ung procedures are contemplated for the next survey and preLin in z ry vmrk on then is being carried out using the steel room atSiL, These studies wouli be cazriec? out only i n volunteers who m y pernzps be given soPe compensation. 1, In view of the finding of unexplained h i g h protein bound io&ne levels in both exposed and we-xposed Rongelap people, we have devised an 1121 thyroid uptake study which will involve orrl adninistration of only1 ~c of the isotope given oraJ.1 ~u;ith water and, by using the Sigt-Jy sensitive .gama spectroscopy in the steel roon, it i s possible t o get a measure of the t5yroid uptake in 24 hours even vLth the -stration of sucfi a sm~llamovlnt of 1131, as, 8s you bow, is only adl fraction of the usual tracer dose used and only a few ar of rafiiztion wo-ald be received by the individual. W e would like to do this study in about 20 volunteers. I t wodd be icie2l t o do it in 10 esposea and 10 uneqosed people, but we ~uoulds ett le for 20 unexcnts, we might be able to help to correct it. ning on doing a complete erythrocytic investigation. inves+Lgation, it v.wad De necessary to h o w the rcd c e l l mass. To do this we- would like to use theCr5I technique using tagged red cells tion of the M.1.C. A c5sturMng finding as0 in the Rongelap people as a whole is the m-enlic tendency. If we can determine the cause of their l o w hezzatoAs part of this This study would be done 011 10 u nwo sed people; .. . _
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Dr. Charles L. Dunham January 16, 19593. A third study would be designed t o deternine if changes i n skeletal growth and metab0li.m have resulted from t h e i r radittion exposure, A tracar technique using S+ would be used to measure the size of the exhangeable calciun pool and the r2tc of acrction of bone salts (ref. Bauer. C. B, and il, De Ray, Kinetics of Strontium Metabolism in Man, J. Bone a n d joint SurSCr}' 2:127, 1958). Thi; offers the only technique avail aue which give rag iznediatc indw of W e growth and adrinistration of onlya very low tracer dose of Sr85 ( 5 pc) is reBy using the whole body counter with this technique, the It i s proposed to do this study on.5--.. rtxposed and 5 unexposed It would be appreciated i f you can l e t m e .know your decision on these proposals (in whole or in part) at yo&convMience. w i l l other approval be necessary frox other agencies, particularly the
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