DocJax

Declassified record · U.S. Department of Energy

Review of the Bio-Medical Program in Operation Greenhouse

Dated
Jan 15, 1950
Document type
Report
Length
17 pages
Open the original scanArchive record OSTI ID 16376641 · public domain

Document text

Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.

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nature in order that the test r,ay serve to correlate wb.t ocez-nic fligilton mouse colonies have besn stl~died, etc. . The

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quslified for their jobs. The persons in charge of the Bio - practical understanding of logistics and organizational problems.

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is ex;:ect~d to be the-hi,ghest r;diz.tion intensity which the teams It will tzke about 4-5 hours to distribute the animals before the shot and a’ool~tan ecual time to r+t’~rnthem to the I;boratories. Immediately after the shot, a hel.ico-t+r will neutron indicators and do minor renqirs concerned with =ir on the island within an ho~r after the shot, v~ill.be ;-repared to repair sts,tions and to obtsin the first two ;:airsof ;i~s and

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ho-no~eneity of the incident r~dietion and the emount of of these phantoms “will be shielding) ; others will be

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shuts off tempo ~rily after the shot to exclud= ;;ossible details Of desi~n but will be very close

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on the Bikini corn. Controls hzve been studied Dr. Conser of Cak Rid<ge~..’il-lbe in CIK rge of this study. ;-nears of the pollen will be nz,de two clzssical times of stu5y) and some of the scoring of the chromosome breaks will be made importance in the st ~dy of neutrons as the increase in br~cks is not (?) linear in the case I nresume that the n~~tron studies with fission,-> pile and cyclotron ne Itronq .sl~ches h~:ve been re,zorted in the literat Ire are being continued.. stations where they will receive an estimated 1010 to 1013 neuts (1~.rgely fast ) ~nd not nore PIZ ced in the cylindrical st>.tions ‘.~’nerethey will be expo~ed m~inly to gam 72 rays. -JelI explored of the biological tests (exce~t for the inhalation). Carter at Zos AILnos has photons of dif~e rent energies znd has calibrated the weight decrease in these lymphoid tis~ues

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excsllent families of clurveswhich show, for studies under si~ulate.1 field conditions have

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2. Long term effects in survivors: ‘1’helife span, tumor incidence and catar~ct ind!~ction will be ~tldied in surviving mice exposed both to neutrons snd gamma rdys. These ~.nimsls will be sent by be pooled in grou:js of four (covering a dose rtingeof 100 roentgens ). Tiotmore thzn 4700 animals will be returned to the Stzt?s. They will be accompanied by controls group, not the pooled groups of fo>~r) . dosimetry is a rather new tool for czli– bra.tion of radiation they should also have control =~niwaxs given doses b~s=d on the icance of the results. ) The dif<er~nce in life .s>s.n,tumor incidence and catzract the ?xncssd animls. The statisticians felt that no more were necessary since the differences in long term effects betwe+n

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unexposed ~ni~~’L~ of this strtiinand those st~tions) will also be returned to Furth. know how tkey are goinfi to control t:~;ese for as=sy. The totzl mdioa.ctivity of the d~termined. In this vay it will be possible zir semyling devices ‘~rillbe used to control

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two instances in -which there has been a philosophy of conducting only well understo~d Ri5~1ifj_cznceof the mouse inhalation data. will not be clezr, but the l,iryorces have

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3100d Chemistry: 50 percent of the dog blood at autopsy will be S>.ved. The pls.smawill be ?he remainder of the plasiilawill be stabilized and preserved by passing through an ion first ~~~~, six in the second, +ch containing elevsn animals (three or four Digs for every dog), % ch animal will be anesthetized and held in place against differ~nt wave length or =.tdif<erent timgs after the will be m-de–-the first, the thermal burns versus tine eyplo.~iOAn~nd during the ceriod thereafter; the second, the burn produced on skin gfi~dua.lly~x~osed by a sliding third, b~rns produced by excluding certain compon~nts of the ultraviolet, the visible, and the infrared li~ht. ‘~ch of these tests will be car ied out on both pigs and-. US DOE ARCHIVES q%’

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dogs and each will have its own control of a STall port which admits all of the therml radisnt energy. The only studies which will be made on the burned areas are }~nother hio7.ogical test that has just bean includsd at thermsl r~di;.tion? on :Ta~~ ~i~cas of material in contact with the -kin. ?wel-~’esuch tests will be ~.ade on four animals in the outer station=. (This will be integrated with the material me>sure the total r~diant energy. These instruments have been designefl so that their records of total energy can be These studies have been well c~ntrolted by preli~inary

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anesthesias hav~ been mde under conditions which si~ula.te those in the Facific. tO large ~urfzce burns have been produced by the scanning technic utilizing t!le focussed been ~roluced with nzgnesium flares. been nl.nr,ed in a more direct or simple ‘.%y in ord~r to get on 2. relatively few groups of animzls. ~he mouse survival

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the obtaining of good results are 1) ~oor placing of stations due to misc~lcula-tionq of the thermal ~nergies and 2) the possibility that the pigs will be to~ large for use. The intez--ret ~3.tho~~ghit mzy ~ive some clue to particle size in At best, ~ood dzta will be obtcined correl.a-tingbiological the Ja’~anese and the arguments as to dose–intensity effects.. If the r~sults from the various tests sho’.lldnot jibe or should conflict, it m2.y still be ~o.s ible to discriminate bet-.,eentrue and siaurious resultq. lhe problems which will ~hich cfin‘Ieobtsined in time in the laboratory but which like thzt done at Bikini will not be carl:iedout.