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counters was modified QOF use with A,c. operated apparatus and further %estsi of fts properties are b e h g carried OIL 10 2 butine Service and Analgsei
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20 1 hlgtical Studies on Serlally Sacrificed % t s to which polonium had been ministered Tlssue analyses for polonium bme been completd i n a eer5al .wcrifice study on rats, fnetitute, and were g:iven a single intravsaow &so of 10 or 20 microcuries of polonium par kilogram o f body weighto 8ame solution within a short pzedod of time, kapt mder +&e same conditions after injection and sacrificed (ethetr) md Ctisszct08 in as similar a manner as poseible and in a pre-errranged order. randlomnlaec2 with sespgct to ordes fhe dosage from the total smwnt of polonium recovered as has boen done in the metabolism experiments. A s the closest POSSibLS approach $0 putting the (lata from the two sets of experiments on a comparable basis the dosages for dummy injection since g2$ was tihe average recocory ob%ainedi n all the metabolism experLments where complete auabytfcal deta were availablea The rats used were a homogenous group o f mles from Wlstar They wero a U injected from tho dicated by Fig, 1, where the per c a t of the dose zetainned in the serial sacrifice group is plottied &round the averago ratentian curve derived f r o m excretion data in the metabolism experiments, COrrec t the dosage for ind2vidunl animal I according t o the fn divi aud recoveries the data show a fairly wide scatter, bu%the grow averages in geploral sbm a goad f i t $0 the ,previously determined retention curvec two a t 10 adtwo at 20 mb mcuries/kg, vere sacrificed atQe 1, 2, 3 , 14, analyzed in animls which died before they were schaluled for sacrifice, but data on total re$enr%ionin these animals ars included in Fi& 1 and in genera1 averaged (in dab p ~ e sante don b e as cro ~ ses )with the closest regular averaged as a special &roupo Since it was not wssible to Groups of four mi mala, fso individual tissues were The three animals which died Betmen 90 and 160 days were,.-
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Percent of the dose Fer gram in tissues of male rats intravenous administra tinn of 10-20 pc/k& o f Days Rat Retention Percent of the dose per gram wet weight in inj'n. Dose Spleen Kidney Liver Lung Cervical Nodes Omental Uodes Bone Testis i l h S C 1 1
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Percent of body content per gram in tissues of male rats sacrificed seri l y following intravenous administration of 10-20 pclkg of polonium 3 .; Percent of body content per gram wet weight in Spleen Kidney Liver Lung Cem icd Nodes Omental Nodes Bone Testis hscle
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202 Effects of IrradlatPon on lpfssus Nucledc Acids Studied with Radioactive phosphorus
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aiffsrentiating cells after therapeutic doses of Bomtgem rmliation, which he attributed t o an accumulation of ribonucleotides i a the cytoplasm, Mo change
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