Archive description
This document is a copy of a scientific journal, but there is no indication of which journal or the exact date of publication. The article shows it was received for publication on july 6, 1948. The article is, as its title implies, about experiments in rats. There is nothing about humans or human experimentation. The document is a poor copy and is difficult to read in places. The copy does not include copies of two plates (i. E., photographic reproductions) of autoradiographs of rat femur. The authors of the article are kenneth g. Scott, dorothy j. Axelrod, harvey fisher, j. H. Crowley, and joseph g. Hamilton. They are identified as members of the divisionof radiology and medicine, crocker radiation laboratory and the division of medical physics, university of california, san francisco and berkeley. The work was performed under contract no. W-7405-eng-4s-a with the manhattan district, us army.
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Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
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--FIG. 1. Proportiom of plutonium found in excreta .nd skeleton of tbe n Vdues CdRdCttd far .bsarption from the left leg.
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d p l u w - @g plsoa after ita hitinl depotsition in the adult -1. Fig. 2 lhm a eation in wMab the perimtmm ww fortuitously stripped off ob &e boas. xadiautograph demondratea that a hrge rwo~n?of plutonium iipmumt in thia rtripped Wer. No aigai6-t d t j o m in the mctahLo khevior of plutonium' were observed in each of ita three valence -tee. It is probable that plutonium, when absorbed and distributed throughout the body, exifits h B single valemce~stab which is independent of its valence at the time of adrnirirjPlutoaium is not absorbed from the ~ ro in test im ltract to say BjgDifjcant degree. Following parenteral administration, the chief organ d aepStion is the skeleton. The soft tissues having the greatest conw~iation d plutmium live, kidney, and spleen; their content of piutonium per gp.,however, L from mefifth to one-tenth that of bone. T b e chief channel of elimination is the digestive tract. The ntte o? plutonium excretion is very slow and its half p e r i d of retention m the LiJxiy Radioautographic studies show that plutonium is depsited p h s ) - iz trabeculsr bone. Examination of many of these preprations suggo;;:? that tbe principal Site of deposition is on the bone surface and that a T ~ Q - limited accumulation takes place in tbe mineral structure ab tbe bone. S o significant mdistri%ution of plutonium took place in the bone durjng &e arid of these experiments. T h e dectivi locslization of the plutonim on the bone sciiaces e . 2 be high tuxieity of plutonium campsred to equivdent qusncirie of xdicz. bis &e& arises from the fact thst the redium is distributed throcg3~:: le mineral portion of the bone, and a large prc ~ ~ rtio nai the ep mick ii bsorbed Mom hey can enter the mamw wvity. Plutonium partid^ id^^ rn bombard bone marrow more readily, since there is & t i d y 1 s F&-- bsorption of radiation by the bone. is €stimatedto be greater than 2 years. I the +3, +4, and +S valence state are pmentcd. Plutonium m not 3und to be abrbed from the gastrointestinal tract to any extent. The keleton waa the main organ af deposition of plutonium, and the dsgree d etention in thin organ WBB very pat. No aignifiamt differencse u w
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