Memo to S Warren, Subject: Mice from Operation Greenhouse

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Q UNITED STATES GOVERNMENT Attached is letter from Dr. Furth listing the condition of the mice which he has eceived from Operation Greenhouse. Dr. Furth has indicated that h had expected to receive 250 KV controls in addition to the stress cent OIS. Arguments for the irradiated controls are determining the LD 50 fo this strain of mice, additional studies on longevity, and pathological hanges. Dr. Zelle states th t at the meeting in the fall of 1950 in Oak Ridge when this program wa discussed it had been indicated that X-ny controls would be sent b ck from Eniwetok. Dr. Zell.eand Dr. Brandt at the time expressed objecti ns to these controls on the basis that the mice from the shot would not have received known dosage. urth about June 1 on his way back from the points out that they do no know what type of radiation and what dosage these mice received. The biological dosimetry experiments are apparently going to disagree with each ther. This is probably due to the shielding received from the variou containers and also biological partitions. There was a lot of soft radia ion from the bombs which was partially shielded by the aluminum conta- ers. From the results of the work at niwetok we will know the ID 50 of this strain of mice in terms of a 250 mchine and in terms of the bomb. This latter value is more imports t to the mice that Dr. Furth now has than those from X-ray work. Additional X-ray controls to be run y Dr. Furthwou2d be more of the nature of a whole new research proje t dealing with pathological changes and longevity of X-radiated mice. Dr Leon Jacobsen and Lorenz have X-ray longevity studies now in progress but “tha different strain. Additional studies may be desirable but this is a parate decision than that of the necessity of X-ray controls for the Gree ouse mice.