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BEST COPY AVAILABLE Uptonj Long Ialandj New York I apologizefor the long delay In aendlng you the data on the Marshall Island subjeata. To avoid further delay I am enoloalngrough drafts of a table and ohart that summarize these data, Total body water waa determinedtith tritiatedwater at Intervalsstarting four hours after admlnlatratlon, samples were lyophilizedand tritium in the water ptmtion oounted in a Nuolear-Chioagoliquid scintillationcounter. Quenohingwae oorreotedby use,of an internalstandardand in whloh z TBW is total body water (In kg) as peraent of gross weight, Lean body maeu (IBM waa taken aa the d&ffer- !enoe betwqen gross weight and fat kg). There is nothing unusual in these subjeotsrelative to ,$otalbody waterl fats or lean body num. ThOrO is no “normal” range tor these quantities, but taking the subjectsas a groups their average values are not very differentfrom averages for Caucaeiansubjeota from this area (San FranclaThe red cell volumes,however, are deoidedlysmaller thnn what tieand other Inventigatorewould ooneldernormal. %is only 2 ,3. I would expeot a value of about 35 mV’W based on our studies. In the enolobed chart, I have plotted blood volume ter (litera)o You wil,lnote that all but one of the Mar8hallese aubjeats lies well below the regremlon Mnoa”,that both MY data have not yet been published. Moo@9S $a~~~~~~gt found in The Body CelX Mke& and Its SuPPoxMm 8
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There 1s no doubt In my mind but that the red cell volumeu you found in the Flarshalle8eare 8ignlfiaantlysmaller than What We have regardedas “normal”, It is my impression that pla6ma volumes may also be slightlysmaller but I will need a littlemore time to oonflrm thlso There 16 nothing more I can add at the moment except perhaps to note that the correlationsbetween BV and TBW, and between RCV and TH4 appear to be better than I have seen for data on other groups of subjeots, Please phone or write if you have any questionsabout the data or their interpretation.