Document text
Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
Page 1
LAWRENCE LIVERMORE FIAT1 ONAL LABORATORY - Operational Safety Procedure HUMAN SUBJECT EXPERIMENTS ITH The Laboratory's basic safety policy is that operations mst b2 planned and conducted ina manner that will prevent injury to personnel or damage t o property, The minimum safety rules and practices necessary f o r achieving an accident-free work environment for the human subject experiments with air tagsed with radioisotopes i n Building 194 are stated in the Operational Safety Everyone in this building, i .e., visitor, mintenance and service employee, and regularly assigned employee, i s required to abide by this procedure and the LCNL Health & Safety Msnuai t o protect hirnse7f and other personnel from injury. Tcegul a r bui i6 ; n g personnei are responsi hie for assi sii ng others inth ? bui 'I d j fig t o uwferstand the safety regulations relating to what they ar2 doing and t o zbide by the safety requirements. This procedure was prepared by building managern2nt assisted by Hazards Control. Confer with the Hazards Control safety team assigned to this building for interpretation of this procedure and for planning your operations t o comply with safety requi rements. Each indi vi dual in this bu i1ding shall use this guidance effectively to avoid injury. This Operational Safety Procedure has been reviewed by: Human Subject Committee
Page 2
Operational Safety Procedure HUMAN SUBJECT EXPERIMENTS UITH The purpose of this study isto measure the rate o f ni’irogen and Argon uptake and elimination inthe body o f normal healthy humans. experiments will -involve breathing o f 13N and 41Ar labelled air for no more than 120 minutes. Any required change i n operations that alters the scope or significantly decreases safety control will not be made until a revision o r supplement to this procedure has been signed by the person authorized t o approve safety control nay be made with the joint concurrence o f the LINAC Cperations ibnager and the Hazards Control Safety Team Leader. Any required change i n operations that does not decrease the 1. This procedure authorizes the exposure o f human subjects t o the a ) Breathing ofair tagged with I3N and 41Ar for up to 120 minutes with a n accompanying dose o f approximately 400 m?em t o the participants. See attached letter from the H ; lman Subjects
Page 3
Operational Safety Procedure breathing mixture a r e based on calculations by Hazards Control's Health Physics Group (see letter from K. Shingleton o f April 12, 1982). The fora 120 minute experiment and for 41Ar i s approximat2ly 6400 &em for . The actual inaximum dose t o participants can be calculated as follows: The breathi ng gas concentrations wi 11 be: Time elzpsed from beam shut - offto administration will be - 20 minutes. With t h i s in mind we then obtain the estimates a t t = 2 0 min. To generate the 13N isotope, high-purity N2 is irradiated with environment, NO2 and N20 forms. The concentration i s controlled by minimizing the presence of O2 i n the nitrogen. Some trace of O2 always i s present and in this ionizing The Operational Controls in paragraph F will reduce the above hazards t o
Page 4
Operational Safety Procedure Paul Meyer is responsible for assuring that all work is performed i n conformance with this OSP and the LLPL Health ?t Safety ilanual. I n his absence, the experiment will be terminated and a responsible person will be trained for the experiment. A11participating employees are responsible for perforni ng thei r work according to the regulations of this OSP. reasonable precaut ions t o prot-ect themsel ves 'and thei r f e l l ow empl oyees and t o perform only those - tasks that they believe can be accomplished safely. When participants have any doubt regarding the safety of any They are expected to take all phase of their work, they are expected t o check with the project supervisor before proceedi ng. The Hazards Control Safety Team assists management to institute and t o maintajn a lo&-risk work environment. In addition, Hazards -Control may request that management o r employees stop an operation when there appears t o be an imminent. danger t o personnel o r property (see Health 8 Safety Manual Section 1.06). 1. The target gases are : a) Ar: Zero grade Argon b) N2: High p z rit y nitrogen(silver colored bottles with pink top).
Page 5
Operational Safety Procedure 2. Waste gas disposal is achieved with large volume blower which pumps gas from the site of the experiment to the outside of Bldg. 194 at the roof 1. All human subjects shall receive a whole body radiation scan by Hazards Control before and after inhalation of radioactive gases. 2. The radioactive gases shall be filtered with a HEPA filter before inhalation by the subjects, gask'ets and canister will be m de prior to filter jn stall ation. 'approved and tested filter cartridge obtained from Hazards Control Respira'ior Branch will be installed in the filter canister. A visual inspection of the filter cartridge The evacuated target gas bottle,located in the 0' cave, is filled from a standard gas cy1 i nder con tai ni ng either h i gh-puri ty nitrogen (N2) o r Zero grade Ar. Upon filling,the gas is being irradiated by LINAC In the case of N2 as target gas, any undesired by-products come from small oxyger; concentrations in the gas bottle.This can lead,in Control personnel, found concentrations of less than1 ppm of NO2 and less than 22 ppm o f N20 i n an irradiated sample. will be tested for NO2 and ozone before it is administered. The breathing mixture a ) Evacuate target - gas bottle to c 50 microns.
Page 6
Operational Safety Procedure Revised: 9/1/84 No. 194.29 -5- Expi res: 9/1/85 c) Bleed radioactive gas as described below, into plastic bag. Check mixture f o r NO2 and 03. Human subjects will not be exposed t o concentrations o f NO2 > 3ppm Navy personnel wi 11 cont i nuously monitor a n d hold 02 concent ration subject in Bl d g. 194 in a plastic bag which i s then connected tothe breathing valve. The subject then breathes for 120 minutes fron the bag. The exhaled gas i s passed through asoda lime trap to remove all Co2 before returning t o the bag. mai ntai ned inthe bag and monitored with abi o-mari ne oxygen defi ci ency meter o r equivalent during use by Navy personnel. A t the ead o f the 120 1 minute period the bag i s disconnected and the subject breathes room air with the washout being vented t o t h e outside of Bldg. 194.
Page 7
Operational Safety Procedure Fire Safety Div. RESPONSNLE Iri DIVI DUAL : UP. Meyer