Contract Number Da-49-146-XZ-029. Contract For: Research Relating to Study the Phenomenon of Amino-Aciduria Following Irradiation (1 January 1960 - 28 February 1961) with Uccm (Signed 01 March ...

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ARTICLE PAGE ASPR Scope of Work, Item I thru V I 1 Estimated Cost and Consideration Property to be Furnished by the Government Rovisional and Final Overhead Rates Allowable Cost and Payment Limitation of Cost Standards of Work Assignment of Claims Utilization of Small Business Concerns Termination for the Convenience of t h e Government Buy American Act Yalsh-Healep Public Contracts Act Xondiscrimination in Employment Officials Not To Benefit Covenant Against Contingent Fees Authorization and Consent Notice and Assistance Regarding, Patent Infrhgement Milit azy Security Requirements Utilization of Coocerns in Labor Surplus Areas FUhg of Patent Applications Negotlated Overhead Rates Notice to Government o f Labor Disputes Limitation on Withholding o f Payments Appmval of Contract Priorities, Allocations and. dllotnents Xnaurance - Liability to Third Persons .-.

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The Contractw, as an independent contractor and not a s an agent of the Government, utilizing special knawbdge and technlques possessed by and a sail able to the Contractor in the field of biological effects of r&- ation, uill deliver t o the Governinent written reports of the results af the research study hereinafter more parbicularly desc--bed. performance of the work under t h i s Contract, the Contractor will furnish all necessarypersonnel, services, facilities and materials. period shall cmmence on the effective date of this conkact, as shum . The overall objective of the research to be performed hereunder is t o study the phenomenon of amino-aciduria following irradiation,- a condit i o n which has been reported in hmans and animals, t o clarFfy some af the mechmisms responsible for amino-aciduria and t o detennine vfiether it is a practical biological test of radiation exposure. acids 9 the Van Slyice and chranatographic techniques. d sages of totdl body irradiation. on urinary acid excretion. In the performance of this Contract, the Contractor ulll undertake 1, Corparison of techniques for detemination of urm -0 3etemination of exeretian of urinary amino acids a t various2. 3. A study of the effects af p & ial versus total body 5rradiatIon b * Studies of the inmrune mechanisms af hrmrans receiving t o t a l body 1. Selection of species and specinens fur investigation, as well as, specific technological procedures, for w e in t h e perfomance of this Ccntract shall be dctermhed by the Cantractor, subject to the approvsl ci the Project Officer. 2. The Contractor vlll co-ordirute tkoxh the Poj ect Officer tte research t o be perforaed under this Contract with other inrrtitutiona, both g over mata l and private, engaged in related radiobiological r e -

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1. The Cop tractors hall suhnit quarterly letter-type progress reports i n duplicate t o the Project Officer. Each such report will indicate the period covered and briefly describe the work accanplished during t h e preceding period and outline the f u t u r e plan of action. The first such report shall be subnitted not later than 1Juno 1960 and shall cover all work from the inception of the wcrk under this Contract through 15 May 1960. quent progress reports s h a l l be submitted every three (3) months thereafter. 2. Upon cmpletion of t h e research required under this Contract, a Final ileport shall be su hit ted by the Contractor t o the Project Officer nzking f a disclosure of all research conducted ln clu d hg the results and conclusi0r.s thereof h-ith appropriate recommendations. The Contractor vill pre?axe the Final Report and a l l other'reports required in the fom-and r;.rurner directed by the Project' Officer. prior t o publication of t h e ma3 Sesozt, a draft thereof,'in duplicate, shall be submitted to the Project Ol'ficer f o r review and approvd. tkc fa.-;^ and aanner required by the Project Officer, the same shall be rct w zed without unreasonable delay t o the Contractcr and shall be proaptly peja red as &-ected bp the Project Officer. In thc event the F i n d Report is not in All reports shall bear the contract number. L 3. Ftcasonablc costs incurred by the Contractor in connection w i t h the ~20::zbleite?A of cost under this Contract, subject t o the provisions of k . ;he Froject Officer vill pmvide for t h e Contractor appropriate Ccc---i%y classification, an appropriate distrlbution list, and assignment -u.ed t o th frat. of thc face page of the Final Report istatement to *.e c*;'fect that tkeproduction in nhole or in part is pennittad for any Z-,e r csu lts of the research &t. .be dellverod t o the Government under. .x nis Coztzzct shall eibody thc mort rezcnt reliable applicable info nation Conl';-scbr fro=! private as w e l l as rovcrrmental sources, and the Contractor z pecs to utilize all sources of nch info nation available t o it. this ceracctlon, information Li t2i3 ficld which I s in the control of the Defeme Atcaic Support kency (hcrcin.dter called VIKSAtf) shall, u i t h the cox eat of the Project officer a.?d under such safeyards and procedures as he zay prescribe, be made ava5lable to the Contractor on request. 4 --. A L-..c ficld of Siolo&cal dfccc ; of radiation which i s available t o the

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L The Contractor agrees to utilize In the performance of the research uork under this Contract' such personnel as a r e highly qualified in the research fields involved, whose professional standards are of the highest, and whose opinions i n such research fields are entitled to respect and confid&ce of recognized experts in t h e field. The Con&kactinE Officer shall designate, i n writing, a representative toact as Project Officer under this Contract. and papers, and other matcrial called forin ARTICLE Is hall be delivered t o the Froject Officer, who shall represent the Contracting Officer in the technical phases of the work, The Conkactor will closely co-ordinate its work under t h i s Contract with the Project.Officer. The Project Officer s b l l not be authorized to issue change orders, contract supplements, or direct any'contract perfomance requiring. a contractual modification o r All reports, technical data 1. Subject to the pro-dsions of Clause KO. 2 of the G e n e r a l Pro- - Lsiox of this Contract entitled nLinitatlon of Costn and of ARl'ICIZ3 VI ::-.e Cc2:racto:ls perfomance hereunder. KO feeis payable under this 2. AS consideration for its w.dert&ings udm.this Conttact, the Cxt.~;cto: shall receive reimbursenent f o r direct costs as provided in

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ARTICLE 111 - REIMBURSABLE COSTS 1. It is understocd and agreed t h a t subject t o the provisions of AXT1Ci.Z VI of this Contract entitled IIAllowable Cost and payment^^, the Government w i l l reimburse the Contractor on suhnission of public vouchers for its costs and expenses reasonably iicurred i n the perfonnance of ita undcrtakines hereunder i n an mmt specified in the schedule. vouchers shall be approved or ratified by the Contracting Officer. Cmt7act.o;. may suhit vouchers at monthly intervals for costs incurred and not previously reimbursed. vision al basis. The Contracting Officer may withhold all or any pat af the final re iz hrs ment pqment until receipt of the Final Report, the ?ropcrty account- a d the patent disclosure and designation required hereunder. All vouchers sutmitted shall indicate wtth respect t o each class af item listed by the Cmtractor thereon, the particular sub par x rah of pa.ragra?h 2 below under uhich reimbursement I s claimed. Payment of such vouchers may be on a pro2. For the purpose of detemiining the mounts peyable t o the Con- &--,..&or under this Contract, allarable itans af cost a be determined by t h e Contrecting Officer in accordance with Patt 3 of Section XV of . the Axed Sc-mices Procurenent Regulation, it being understood and agreed, M-YcoEt lh it ing the generalibj of the foregoing that the following shall be car side cd as allauable itens of cost hereunder when incurred or paid by t+e Contractor and w k n necessary and required and used for t h e perr--..--’ c: hc-zLy paid personnel), sick leave, holiday pay, jury duty and r.2:k.y~ lcz-.-c, pxrsuant t o t h e estzblished practice of the Contractor, px p z ly a??Ucable to sah salaries and wages of ita personnel directLy e xxe d In the perZonance of this Contract. b. Xzterials a i d Services - Fxpenditures by the Contraciaor for t,l c y & pent from others), pr qc rly allocable t o performance of the work hcrc--dcr, and fc: the sen ices of others not rclnbursed under subparagrqh - LZ z-2 n c c e s s q Cor thc ?erforzw.c.cc of its undertakings hereurider, The CZicer, SOUs c z q gereratcd Ln the ?erforx..ce of this Contract, and the procccds on any such sale shall be cxd it cd to this Contract.

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(1) Expenditures by the Contractor for the transportation.of the persons directly engriged in the performance of work hereunder, and in connection therewith, and such reasonable subsistence expenses incurred by such persons, in an mount not exceeding fifteen dollars ($15.00) per person per day, or fraction thereof, during periods of such travel, or, at the Contractor's option, an allowance in l i e u of actual subsistence expenses of such persons, not exceeding t w e l v e dollars ($12.00) per person for each day, or major fraction thereof, during the period of such travel. Provided that expenses for transportation hereunder by motor vehicle other tkm carrier or rented automobile shall be reimbursed on an actual cost basis, or, at the Contractor's option, on a mileage basis at a r a t e not exceeding eight (8) cents per mile per vehicle, in l i e u of t h e actual expenses of such Expenditures by the Contractor for the transportation of persoss c?irectly engaged inthe performance of work hereunder, and i n conxc tion therewith outside the continental United States, and -subsistence &?else at the rates prescribed in paragraph 1above or such other rates as ;.;i;>zilly agreed u?on with the Contracting Officer; rovided, that a l l such foreiga travel shall be authorized and %proved in w ntl n g\y the Contract - (3) Dcpenditures for transpol-tation and travel not specificc y covered i n the above may be a matter of separate negotiation under b & ~ L u C contracts with the cognizant Contracting Officer. e. Zns-xaxe - The c o s t of insurance authorized or required under :.:< 1:: cxcess of those Vovlded under Policy ED-502 with the Indemnity ,.,,,.ce Crzr?ary of ti or th America) as the Contractor may dean necessary in ;cco:dJ-:ce irith h i s established practice, and not provided for under other provisions in this Contract. Sukontracts - mend ltu res by the Contractor representing ? a ; ~ - cats to succonxactors for contract work performed or materials and G: sia.:t cites or for restoring such facilities or plant sites ta subz.cz~:it d such re man ipn cnt or relocation, the Contsactor shall return t o or credit the Government with the portion of the reimbursement by the Covc;..lent for its emenditmes therefor dot mined *JYnegotiation between ---"--,L..L.u-cs by #e Contractor f o r rezrranGment or relocation of facilities

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i. Taxes - Bqenditures for federal, state and local taxes (aelusive of taxes measured by income) and Of export OT import duties uhj.& are directly chargeable to this Contract t o the extent that exemption therefrom is not available and tothe extent that such taxes are not Included in Overhead - Such amounts representing Contractorrs overhead costs as are equal t o the percentage set forth inthe schedule of the asiounts mended for direct ar properly allocable salaries and wages of personnel allowed as item of cost under paragraph a above, it having been de tez in ed by the Contracting Officer that, far the purpose of this Cont-act the faregolng computation is reasonable and t h a t amounts so cmputed accurately reflect t h e overhead costs properly allocable t o work perfarmed under this Contract. Services of Consultants - menses for services of consultants at rates approved in advance by the Contracting Officer. I 1. Fre-contract and Other Costs - Costs incurred by the Contractor Ir xi dental to work covered by the Contract. but Drior t o the effective date oZ the Contract, and other costs'properly hoc able to perfomance of the wsrk -hich, in the opinion of t h e Contracting Officer, are properly reimburs- & l e t o the Contractor. When the Contractor claims reimbursement for an 5tc. of cost under this subparagraph, such it a a will be specific d ly identifie dad described; the period i n which it was incurred will be set forth; th Contractor wlll furnish full information thereon if requested by the Ccntracting Officer. Contractor shall exercise due diligence t o secure materials snd scrr',ces at the nost advantageous prices available, having due regard t o %? follc. - h ~i t a of property shall be furnished by the Government t o the Conkactor for the performance of this Contractr 7 ~ :p z ? oscs of Clause 28 of the General Provisions of this Contract en1. A provisional Ung rate of 35%of Sjlaries and bges shall 2. The Contractor shall sutmit a final overhead r a t e at the end of

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(a) For the performance of this Contract, the Cove ment shu pay t o the Contractor the cost thereof (hereinafter referred t o as nu ow able cost") determined by Contracting Officer t o be allowable in accordace with- (i) Part 3.0f Section XV of the Armed Services. Procurement regulation as in effect on the date of this contract; and (ii) the terms of this Contract. (b) Once each month (or a t more frequent intervals, if approved Contrzctjng Officer) the Contractor may subnit t o an authorized representatiJe of Contracting Officer, i n such form and reasonable detail as such representative.may require, an invoice or public voucher supported by a statement of cost incurred by the Contractor i n the performance of this Contract and claimed t o constitute allowable cost. (c) Promptly after receipt of each invoice or voucher t h e Covement shall, subject t o the provisions of (d) below, make payment thereon as =??roved by Contracting Officer. eighty percent (80:) of the total estimated cost of performance of this Contract set forth in the Schedule, further payment on account of allavable cost shall be withheld until a reserve of either one percent (1s) of s x h ' total estinated cost, or ten thousand dollars ($10,000) whichever Is less,shall have been set aside. nfter payment O f an mount-equal t o Coni:&cting Officer may have the invoices or vouchers a dst at ment s of for azounts included i n the related invoice or voucher which are found by Cont-actbg Officer, on the basis …