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Percent of the dose per gram in tissue ~of male mta sacrificed seri1Y following intravenous miminietm tion of 10-20 p c / ~of poloniumtld Days Bat Retention Percent 'of the doae per gran; vet velght i n after NO. P of
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20 2 Effects of Ir radi atP on on Tiosue Nucl,eic Acids 1, Swei - y of the literature A brief summary ofthe literature on the effects c firm dl ation on tlasub nucleic acids indicated E h = t results of various workers are not Ln canplete agreement a1 though it mag be E coaseqaence of dffforent experinentnl conditionso JensenDsSarCorJa in the rat with the rat ot1:ervise shielded from the %Say beem, found l/J to 4 8 6 ,meh newly formed GGsoxyribose nucleic e C l d hn the tumor as compared with usir?adfe ted a3ntrolco A160 normabptr; which were exposed to 1460-3COOr thole b o w irradiations, injected with P and sacr if bcs d two kows latero conk inert from 4to 1/3 8 s much newly formed desoxyribose nucleic acid in liver, spleen, End iztestinal mucosa as the corresponding controls', the formtion of desoxyribose nucleic a c i d in the growing tissues of 3 to 4 day 014 ratso Xf tho r a t was saerfficad. imrnediatob~after exposure t o K. radiation, tho newly forned dssoxyrlbse nucleic acid was 1/10 of fts norm1 value, About three-fourthu sf the inhibiting effect produced by X-radiation ceaeed in the first two fours =iter exposureo was retained 18 the nuclmp~;.otainTractlan ~f the spleen, l i v e r , lymph nodes (lethal to X ) mice in two weeks) were given than When 8 microcuries were given, end 2 clays after the administration lipid, acid and wzter soluble P were renoved end contained ribs3 nV.clooprOteh, desoxyribose nucleoprotein, anri phosphoproteino The mfce wexe sacrfflced at hBI-,. The nucleoprotsln fraction COAsfs%Qd0 % the tissue residue after krshak (Jo G a y physiol. Fi 2s275, 1941) used mice with 13 dag 018 lpmpbmas which were given 200r X-radietion, Pj2 injected hour later, and sacrificad at 2, 3 , 6 t 12, and 24 hoi3rs after Prradiatfono %e centration of the irp a dia ted twmr t%ssuo m s sl,ighbly Leas than the control bmorp while the cmcmtraTion i n the irred.iatad tumor nuctsi vas about 6C$ greater than the control 2 hours after ir ra dhl bn md from l0-20$ greater than the control at 2 hour0 and decreased to +c.-~o;$less than the c o n t r o l at 5-24 burs. and nucleic a c f d fractionot,ion were n o t Qne on the tissues and nuclei from the irradiated mice, so it isnot csrtak whether thePj2 c-ges in the nuclei may be attributed to tbe dssor;y-rtbose nucleic a d d ?,hoaphomsO hhrshak bas shown that about go$ of lymphom nuclaar pbs ph on s is in the zazzcleopPoteia fraction, and dssoxyrtbose nucleic a d d is belieme ;lo constitute f m ~97-100$ of the nucleic acid fm c lion of nucleio
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In order t o give some indication o f me rala’cive he t f vi ties of the three fractions, an4 t h e three tiseaes, %he per cent of injected doios per gram of phosphortns, and the m tio sQ ? the acli ~ itiss group are given i r i Table 3 f o r the 6 0 0 ~zxperimanti) the experimental and control
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' he study of the act i vlt be s of the two nucleic acids as influenced by lo pmnourrced change wa9 observed in the twolrrn'dietion should be exc;e!dodo experiments a'; 6 O O r ~d.16001-,but i t appears that the route of sdmhfstratfon o f the radioactive P~OEPBOXWS,and the time of injection with reference to the t h e o f irmr2ie.tion may %e intportwte IaJection ob the phosphorus intmvenously before radiation was starten as was &ne, in our experiments may very likely give results d1fi"orznt from those in which 2%was admhistered. after sadlation was begun or after radiateion m s terminated, Marsh?& m d administered the pj2 in:m.t.enously afeer the injection was %sm'%xated, or fnterrupke:? the rafiiatiofi t o mako the hj ect i ono was not acbialstersd after irradistim, the rat, however, being exposed to In the case 20 3 Hums~n. Tracer Studies w l 2 h Uranim 234, 235
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Uranium in urine and feces8 mde both before and after the injection. the fluarescance and tihe plating and alpha aunt ing use80deo w l ; i & * tivo mllactiomtrs of wkae and feces were Amilyseo tiere carried out by bath of the muting method are available for this reprto No uranium vae found in the excretion in wine and feme Effect of Rcrd ILacLlon, Rlaod C out ad Blood Chmistq3 Tho sni ao add Lc root in iw ratio did not incressa in the post injection period (%ble 31 significant facrease in u,-'lnary pwi e in or caklasc, De.tt9. on other clinical Zests
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