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Dr. Hamilton, brookhaven, discusses the logic in stating that he believes that 100 rads would be a reasonable limit one might expect th total body to receive in the process of being treated for cancer with pions. He warns, however, that there might be problems with cataract formation at that dose and recommends shielding the eyes during treatment. The median dose that produced cataracts was determined to 100 rads in cyclotron workers.
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BROOKHAVEN NATIONAL LABORATORY ASSOCIATED UNIVERSITIES. INC. TU. AREA CODE St6 YAP MAW 4-62e2 As pr dred I have done a little more study on the problem of how much total body ir radi8tloa one might re8sacubly expect someone to tolerate while being treated for cancer with meson#. You will recall that ia our firrt dlrcu8rioa you wanted 8- idea of an order of magnitude 1, 10, o r 100 rad. malignant condition and that the over-all treatment time I8 approxlmtely one mek, I believe that the tolerable total-body dore would be around 100 tad. radiological procodurea I s given I n the 1962 UN report. But, the mort ccmprehenrive rl u lys i rir given by the final report of the Adrian Conmilttee, "Radiological Hazards t o Patientr," publirhed in London, 1966, by Her Mj crt y ' r Stationery Office. enclosing Table A-V from thir report; thir giver the mean marrou do8e per treatment course f o r treatment of varlour malignancies. of 10 rad as the average total bone marrow exposure in patients given r rdi ation therapy f o r non-mal igrvnt conditions. high voltage equlfment of 1 UeV and more -- from direct irradiation the area of patieate coverad by the diaphtagm of the coll imt or receiver not more than 5% of the mean tumor dore; t h e rest of the patient receiver no lerr than 0.1% of the mean trrnor Thlr dore doer not include internal scatter from the tir8uer irradiated. tothe figure of 100 rad total-body dore (direct and from internal rca tter, If any) with one notable exception, namely, the hazard of cataract production, Thir dAager i s dircusred a t some lewth in the UN 1962 report Prom 100 rod the hazard of leukamogearrlr would roughly equal tie risk of developing Ieukemla rpontaneourly and increared carcinogenesis would be roughly also equivalent to thir. problem of the cataract, houever, means that the heads of iadlvldualr treated dl1 have t o be adequately shielded since the median dose producing cataracts Sa the cyclotron phyrics w s roughly 100 rad. On the rsrumptioa that the patient h ~ sa Some information on the mean marrow dore and genetic dore frtm v a r i a r a n In addition, the report giver a figure A8 you are undoubtedly ausre with contemporary x-ray equipment -- including There limits, achieved by contemporary colli m tio a, hold for linear accelerators. In the light of the Adrian report and there data, I believe w could stick **. Enclosure Division of Microbiology 00133006.001
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