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80 Pifp mifw - rats l e I)aily doseo on rots - swid. 2. Tests of the rape ~ i cagents 1. Effect of single doses of fast neutrons on mbbita 2 0 Extraction stack smp analysis 2. Fllstrllurgical LaboratorJP math Service 4, Clinical laboratory examinations Continuous exposure f o r 8 hours &fly Continuow expocure f o r 24 hours daily single acute exposure (300 r i n De cont miinat ion e t uti ies Projected studies far the next two months
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The .percentage of off-scale madings of pocket chembers has increased 14 sources have been calibmtod for TI. from 3,60 t o 4,75 inthe last tw months. A comparison of pocbt charaber an8 fUm mter readings shm dfffsmnces due f o r the m s $ part probably !io nonsources, have been partially calibrated, Contamination of laundry 3s ob s emd t o dote is mmmd i n the laundering process. 1: Linde m elect mt or has been assembled ina vacuum tight box, ThO new 2rpo cbt chmber eh mr cod iw which are about 30$ hi@ in X - m y recion. The electrometer f o r the new chmber makes ordinary pocket chcmbors .good t o 0,4 ro T%as-.zremnts indicate that pocket chamborn monitor slov neutronso Rats with l Qp ted eoophwi and exposed to SrO’ mist throu@ a tracheal Active material m s rexncmd in 8 few hours from lunes m d bronchi; intestinal t o 23’’ mist; activity i n the lung did not drop significantly durine 2 bYs, Mice injected With SI!@ in doses from 0,016 to 2 x lo4 c/e;m am bel= maintained for chronic effec*s. times, aich is siu il wto concentration by olieletal tissues, A t sewn neeks no retardation i n eromth is kbture foWe goldfish concentrate fisoion mix tun3 in the ovaries 10 - 15 so concentratod by the ovaries. - Mid-lethtLL dose of Sr f o r mts is 6.5 x 10 C/gm by injection a d of f f s - I o n n.btu.r&bby stomach tube, or 10 C/ep of Baffl- LaiE by injection; a-sts that som effects nay be apparent oftor 25 rppbut probably not after hprossion of white cell count ms$und in rat ceiv 27.5 x lo* C/ep1 The microscopic dmqp i n rabbits after 100 r has boen surrmnrfzed and A smple of mater fron tho extraction otaclr m p a t Clinton indicstes that it can be used for a, 3purce of carrier-fme activity ronainod aftor l? nixturo of fission products nhich nay haw been carried as sprayo 1.lore than half of the extraction, and thia rms found t o be due toa Rats radiated with a single dose of x b . r ~ y s (800 r) showed no c h w . ”in the serum protein concentration tzp t o the nppamnce o tm‘nte 93 fxol symptms, when the serum protein and the N.I?,N, values rb QO, values of liver slices fron rata tron ted crith x-ray^ t o 200 r) showed sane dininution r h b meammd in the pre
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and pyruvate. This inhibition nms observed when a single dose of 800 r and MOr mere applied t o the rats. TJyosIn (adenosinstriphosphatase) i n borate buffer v.7~6largely inhibit od by application of 5000 rat Oo; i n veronal buf'fer it m s c-letely inhibited. Partially inhibited myosin mas reactivatod by addition of glutathione. Color pliotopaphy of hands was begun, Fingerprint impression studies have continusd, Product excretion studies wem started, Product laboratories in Neiv Cherxliatsy continue t o show hi@ a u t o madings, Film badges have been supplied t o the Cyclotron ere7 a t St. Louis, Vith 200 r the effect ms in simi fi cmt. A resume of the clinical laboratory exminations during the period fram AprU 15, 1944 t o 1.ltiy 15, 1944 is given, A total of 5074 laboratory procedms viere dome A t o t a l of 8% abnormlitiea 77em found, 'I"hr00 individuals were thom t to have blood ab nom di ties CLS a result of ovemxposw to im di ation, A Wphically exposed surmnc~of tho biochemical studies on project peraomel is presented. viduals exposed to heavy r;;etals. Olcyfluoride exposure produces an elmrated urim tuballoy, The fluoresconco technique pennits the estimation of considerably less th& 1/30 gamm of tuba l cy in urine. Porphyrin metabolism is definitely affected in incliSem sulfur is elevated in individuals exposed to There ~ r ano essential changes i n the blood picture of dl1 experimental R constantly l o m r than mrnal white count, not cormtine, of course, those anime3.s that developed malignant lympham. All anWs on the lovmr levels show an esoentially n o N blood picture. =ached 3500 r t o date. Of the original 48 animls of this level, 33 are still alive a t an age o f approximately 1 7 months. in the blood picture of' tke experimental guinea pig6 since l a s t month's report. On the 8 r per 8 hour levc1, two of the first sories am still alive(total dose 3500 r); om of the second series ( t o t a l dooe 1500 r); none of the nab inbred guinea pies (fanflr 21, still alive (totnl dose 1050 r)(, FOW male and four f e m e inbred minee pies of family 13 a m eqosed c n this level since the beginning of: the mnth. guinea pigs that cam t o autopsy during the month due t o moribund condition o r died, shmd all sevom anemia, with tho exception of one, a lovf total white count, low platQlet count,, and a relative lymphocytosis. The lethal dose of the inbred mnle guinea pigs m n p d fmm1200 t o 1600 r, and thzt of the hybrid guinea pigs of the second sories (one still living) from 625 t o 1300 ro The guinea piga of the 4 r per 8 hour level show persist at lorr wlwa of Ell1 countsz One # pima pic of this level ems killed during the nonth on account of amnia ( t o t a l dose 1700 r). So farl 6 out of the 18 Guinea pigs of this level mre k fl led an8 autopsied with lethal doses ranging from 900 t o 1700 r. ??le guinea pies on tho loner Levels uhow an essentially norClcZl blood pic tur c. 'ko blood picturn of the rabbits is nonnal with the excoption of that of the three animal8 on the 0 r per 8 hour leml vhich show a lowered total rh it e count zith 1mhOOnly the nice of the 8 r per 8 hour levo1 have "he dose of the 8 r per 8 hour level has Them io also no essential change S4.1 fenale guinea pigs of the fa-y 2 m e The lungs of W e rdce used i n the bmeding experiment show sugGestive evidence of a slight increase in lung tunor incidence with dosos abom 1000 re deihm of tb. United sate^ within the msaniag of tbr or the revelation of its contents in any manner to a uiirtudmckyd pehon ir prohibited by law.
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A nev ex per bent m sot up on the8r per 8 hour levo1 for the study of lune twir incidence follovslw doses o f 2000 ror nore. For this exporimnf, Strain A mice mer0 used as their sw cop tibi lit y to lung tunors is lii&her than that of rosults i n disappearance of all f o ~ llcle ofron the ovaries at old age, mhereas this result is not found rThen a canparable total dose is givon chronically a t the rate of 3,l rper day, In nice approx imt ely 50 r, when given c1s m acute e&osure early in ii fe, T e s t e s ail1 rocover completely fron an acute exnosure of 50 ro Another lnalignant l~ymphomhas boen observed i n a nale muse that had been e-xposod on the 8 r per 8 hour lovol for a total of 3000 ro Guinea pf&s of tho 8ror4rpr0 hour level that camto autopsy contin ue to hmc pctchy ecchymoses of the snall intestine. extreme Trhile ovaries contain numoroua sx3.l and larp follicles. atrophy is sli@t t o rmdoratc in mount. Testicular atrophy is Tppo nale guinoa pigs of the 8 r por 5 hour love1 examined &or o. t o t a l dose of 250 r failed to show any testicular atrophy. It has previously been reportad that animals receiving G total of 500 rat this level 8hotmd marked Rodio-autographic End decontamination studies am being continued, Tracer localization tabs place in any of the organs nith tho exception of the kidney, Following in trap ln on or y administration the lung retention ms found t o be in the body ~ m seliminated, 4 tellurium up t o 32 days indicate that no striking degme of A t the end of this interval approximately 90% of the tellurium Other work beiw done by the Eerkeley 6mUp alrpsnrs
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Eo Oo Tollan, Consulting Section Chief out that the blackening i n now developer i s about lqg Zm. it cones back tothe vhlue of old developer and retains it indefinitely - Pocket Climbers and Film !deters These activities have been carried on as usual o It may bo pointed After a few days As mary of the retidings for tho post two months is included: Total nuxnber of readings (daily) Nurilber of off-scale readings Total number of readings 3030 The total oxposuros for the two month period for those individuals (approximately 275) having both meters have been tabulated. a t random from the list are given bclowi The results for 25 people chosen
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%sides thc errors inherent in the instrumonts tinu those comaittod i n rotading there am other reiisons why tho totals differ o Perhaps the port ant of tncso is that the rw torc ur u not always worn sirwltuneouslyo IIowover making tlic assumption that workers wear one ortho other or both when their jobs arc "lmt" - this is twrne out fairly well by observation - it i o cloar that the exposure of workars doas not roach hazardous levels - Tho fact that thc pcrccntade of off-scale readings h m increased from 3,68 t o 4,75 since the last tabulation two months ago clay bo due t o hi,;her humidityo It shu ul d bc pointed out that rimdings are tnkan u t 24 hour interval so Brown, Cesenbcrg and Lester have continudd the calibration of sources for p.. Also adequate m u convenient shields have been provided for them, Yhen the ,job i s finishod 32 sources will have been measured - 16 Ra?e sources and 1 6 uImixe(; sources, The R a content of a11 and t h e neutron emission of t h e mixed sources are t o be cietcrmined, During the month the following moasuroMeasured Rti Content
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A ncvr eluctrometor desi6ned for source calibration has been constructed novoment of fibre. I t his ruther. good proportionality between intensity Rnd rate In addition to the source neasurenonts, the facilities of the ca libra - Requests for repttirs t o Lauritsens tion room were tisod further by the on lib ration of survey instruments, this work was a service to other section so and the projection minometer have been larger thun usual, A rather encouraging result c me out of an experiment t o determine to what oxtent ordinary laundering decontaminates garnents. items and 37 non contaminated mer0 sent to tho laundryo chosen as tho line separating the two. time tile second m i n t was made. 91 wero not contmintited tind 2 pieces had counts of 1100/min, and 1300/,min, Itis very doubtful i f these counts Of the 93 pieces returned a t the The In str ment Section is about rcauy t o slipply rne tur s for tile hand countor and shoe counter assomhlod i n our group for T':est Stands. they will be ready for USC i n the nw rf ut uro " Aftor sone dulay due t o shop concontration on other work the vucuum It has beon box for a Lindemann electrometer has been completed, have completed the elec5rometor system ttnc tire testing it. deterrnined alroady that3l & or les e of IJraniim i n the chamber can he collected in the precipitron, work m d parts huve been constructed, insulator troubles in the electrometer, are not removed, improvcment over the br shem electrometer us was hoped, system i a adaptable to severcll tyl,i:s o f recrsiircmontsu missing parts for an extrapolation chmber lmva been constructed and it should bo easy toput one i n operation, Goldfitein und Crane The systex can bo usad t o neanurc tho activity of dust samples It has been dosigned f o r double chmber The vticuum box sh oulu eliminate S\lcil trou b lcs in the chanbur insulator If they should predominate, t h e cystern may not be as b i g an The new 2 r pocket ch wbc r hlis been put throiigh nom tests- The insulator ha3 now a loukags less than ,05 rin 40 hours and is improving, Thore i s no reason f o r it to ret;ress as it is protocted from outside air, 3% high inthe X-ruy region (50KV t o 100KV) by cornprison with a Victoroon ' I t has been investigated for wave 1oni;tli independence, Readings &re about
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the former - s i n c e the rerldings were taken on R 25 r Victoreen instnirnsnt end only tho first two divisions of the s calo were usedo these tests we compurcd the rea\Jin(;o nith some 0,2 r churnbers, some having chanbers without the ,;rctphitc ran ubout 10% hiC;hero Thr? results coulu bo better or worse - on0 woulu expect In tilts X-ray region the The ne% projection ole c tr one tor containing A IAneverk type electroscope hws beon tested w i t h some 0.2 I- chanborn, chmbors are found t o Le goou up t o 0,4 r as the follonin,; cratti mill indicate After the ,4 r exposuro the clinmber still htis'a potenti d difference of approxiraately 40 volts Yjhich should be enough for saturation, that th5.s instrumerit will holu its characteristics rocom.iend it strongly, capture radirition due t o slow neutrons incident in the body have a fairly constant intensity for the first4 cms i n tho body und then r"ti1ls off, A pockot chornbcr worn i n the usual way shoulu tilerofore Give adeque.1,e monitori n g of slow neutrons, late a section of the body, depths i n tile block, at tint : ChicaGo Cyclotron and more recently at tho Ari;onne, three sets o f ruadings were taken; one without tiny shield arounu the paraffin, one with a Cd, shield and one wvith a Boron shield, The cb shield was omitted atthe Argonlie. ?%le …
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