Reports from the Ad Hoc Committee on Project: Electron Irradiation of Human Skin. Includes Reports, Proposals and Correspondence, and Final Technical Documentary Report

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25. (IJ) Five meetings of t h e Ad Hoc Committee have been held. The problems of space radiation associated with space flight have been presented to the conenittee, Reviews of the SWR in-house research pertaining.to superficial proton and electron exposuren have a l s o been presented. Each of the various members have discussed the types of exposures he has employed in radiatherapy and some of the resultant skin manifestaThere are no additional meetings scheduled. A draft of the final report of the -c dttee has been received and contract will be terminated on 31December 1969. The members have also suggested additional reaearch t h a t might be performed.

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PI fi ii 25. (U) Research effort written under 7757 04 022.

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Ad Floc Committee lljder in planning manned rpace flight#. 25. Approach: (U) Aa Ad Ibc Comdttee of renowned radiotherapirtr, phyricirtr rad path. &logirtS i r to be,otganised by the contractor. The cornnittea &ere are to meet twicc yearly for two y q r r to present their individual obrervrtionr on therapy patients and to dircurr poarible methods of obtaining the info mt i op described in the technical . d l 1 be comparid with animal data obtained under the rame rxpoaure parameters. thir animal to man correlation it may be poreible to extrapofate additional animal point. to eetimate the effect6 in ,human# to urporurer of proton Irradiation, prcrtractec dore rate expoaurer, and other parameterr which are not employed in human therapy. 26. Progrera: (U) None; new contract. It i r alao anticipated tbt human data pointr brought out by this dttec

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Ststemd d Operation te - Signsdwe Date Signature Date Date Ll gnat tue

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Witnessed Operation (Obtain 2 Signatures) Read and Undrstand ( O d i n 2 Signatures) SigMtllr@ Date Signatwe usur

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has been received and found FJl609-67-C-011:Z certify t3et 6 Final Repon on Contract No. Xave been setiefied. I recommend that this Final Report: recomendationa after I have ccmplekeed all review. I will subnit the be published ina civlllan jourd. be published with changes. X not be PUbLIShed (If this recammerdatfon i s msde, explala briefly.) Tnis contract was procured for the intention of obraining an insight of present knowledge an& fo;. suggestsd courses of action for future researcn i n the area of skin radiation effects. :&ch of the data in the final report is based on the unpublished impressions o f ra&iotherapists and as such it is not suitable for dissemination t o the scientific cmm n it y,

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USAF SCHOOL OF AEROSPACE MEDICINE (AFSC) BROOKS AIR FORCE BASE. TEXAS 78235 New Englad Dsaconess Hospital information for work u n i t documentation on DD Form 1498. Fonrsrdcd f o r your file and information are two copice of subject It rlll be necessary for you t o provide this office the following a. Ram tl va description of the work of about 300 wor& -, t o include t h e rollawing paragraphe: technical objectives, technical qwetiona beiag explored ,anticipated applications of the results, etc. Briefly outline the plan, includisg specific tests or experiments 8.1% conducted, cite major technical problems, factors which mya f lect rate of progress of the work.

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NEW ENGLAND DEACONESS HOSPITAL SECTION I - Supplies o r Services Contract Line Items to obtain through the course of normel radiotherapy the best estimate por rib le of the : threshold &res for var i wr biological effects in humans exposed to electron or proton therapy aa requirod by Attrchmeat 1. letter dated 22 August 1967 i r incorporated here in by reference. furnirb a11 qualified perronnel, fac ili tier, test quipment, material and travel, a8 necesrsr Tranacrfptr of meetings as prescribed i n Draft Final Technical Documentary Report i n accordance with Attachment 2. Pin81 Technical Documentary Report i n quintuplic in accordance with Attachment 2. . A completed DD Porn 1473, Document Control Data - UD,shall be included i n each copy of the final report required by this contract. All report6 rubmitted i n compliance with thin cont rw t shall bear the Contract Numher and Project-

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PART I - T M OF PERFORMANCE AND DELIVERY INSTRUCTIONS The Contractor shall comence performance of the work set forth in SECTION I above on or after1 October 1967 and 6uch work shall be completed i n accordance vith t h e following schedule: AS OF DATE lM Ru uc rip t of Meetings lAB Draft Final 'Ta&!t@.&'i-- 1 October 1969 wlbetiugr will be schwduled by Cmmlttee Chairman. mcheduled beyond 1 October ,1969. or before 31 October 1969.-. The final a opie s ' o f the report shall be sub dt ted on or before 31 Dacerabe..i96?. . Ib.due date of the final copies i s contingent upon recoipt by the Contractor of notice of approval ao t o content-and format of draft 'copy within thirty - day6 after receipt of the draft copy, upon the part of the Government to furnish approval within t h e prescribed time, vhich failure is due to the fault of the Gwernment, shall constitute an excurable delay as contemplated by t h e General Provisio*,hereof. However. in the event approval i6 delayed due to the failure of-the Contractor t o conform tothe contract requirement$, the Contractor shall bc cmsidered delinquent in hi. performance hereunder. A. All report8 called for hereunder shall be delivered tothe Government prepaid addressed to the office designated below, wW office is also - desig - mted ar. the point of inspection and acceptance of the reports called for'under USAF School of Aerospace Medicine Aerospace Medical Division (APSC) Brooks A i r Force %$le, Texas 78235 B. One copy of each letter transmitting repo- a h a l l be submitt&:' .

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Administrative Office designated on Standard Form 26. Aerospace Medical Division (AFSC) Brooks A i r Force Base, Texas 78235 C. One copy of full transcription of each meeting will be furnished to: 1. Aerospace Medical Division (AFSC) Brooks A i r Force Base, Texas 70235 2. Each connnittee member. PART 111 - CONSIDERATION AND PAYIBNT Ihe estimated cost of this contract as kontemplated by the LIMITATION OF COST General Provision, is XRIRTY THOUSAND DOLLARS AND NO CENTS ($30,000.00). PART IV - TRAVEL o r subsistence are furnished, the Contractor shall be reimbursed for transport ation costs including travel by motor vehicles plus quarters and subsistence expenses i n accordance with the established travel policy for its employees traveling at the Contractor's expense, Except for air travel costa and when either or both Government quarters B. 'he Contractor agrees inthe performance of necessary air travel, except travel by bush plane, all o cable to this contract, t o use air coach, tourist class. o r similar-accommodations tothe extent consistent with the efficient conduct of business. C. If Government quarters o r subsistence or both are furnished t h e Contractor,the per diem rates will be reduced t o be comparable t o those paid DOD personnel f o r t h e area based on the quarters and subsistence furnished. When applicable, such reductions ahall not affect the fee.payable under this D. Travel to scientific and professional meetings and foreign travel, which includes travel to Alaska and Hawaii, shall require the specific, prior, individual approval of t h e Contracting Officer. A. Notwithstanding any other of the provisions of this contract, the Contracting Officer shall be the only individual authorised on behalf of the Government t o negotiate an amendment o r redirection of effort to the terms of this contract. Ihe rights obtained by the Gove ent i n Technical Data are set for& in the Data Clause incorporated i n the cx r act, and nothing elfwhere in this - .

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contract or i n any documents incorporated by reference in this contract shall be construed asin any way altering such rights. Pursuant t o t h e provisions of the ACKNOWLEDGMENT OF SPONSORSHIP &nerc] Aero-Provision hereof, the Sponsor for this contract i s hereby designated as: rpacc Medical Division, Air Force Systems bumand, United States Air Force. D. REUSE OF NEWS INFORMTION (NEWS MEDIA) No news release, public announcement,~denialor confirmation of same o r any part ofthe subject matter of this contract o r any phase of any program hereunder shall be made without the pr tor written approval of the Contracting Officer. - It is the Air Force Policy t o encourage the publication of scientific and technological advances and information developed under i t s contracts. tri but ion or publication of technical reports that are required by the Air Force i n frtlfillment of this contract shall be handled as prescribed by the provisions of AFR 310-2. the Contractor plans t o release publicly will be forwarded tothe Contracting Officer at least thirty days prior to such release. Data o r infonuation stemming from this contract which The Patent Ughts (Deferred) clause of the General Provisions may be replaced by t h e Patent Rights (License) clause when the Contractor’s patent policy i~approved by t h e Department of Defense. PART VI - CONTRACT SCHEDULE IlIsMs REQUIRING EXPERIMENTAL, DEVELOPMENTAL, OR For purposes of defining the nature of the work and the scope of rights i n data granted tothe Government pursuant t o Clause 13, entitled “Rights i n Technical Data,” it is understood and agreed t h a t the work specLfied requires the performance of experimental, developmental, o r research work. PART V I 1 - CONTRACTUAL CONTENTS This contract consists of: a. Standard Form 26, AWARD/CONTRACT. on one page. b. An Administrative Commitment Document, AFPI Form 6B, dated 25 September 1967, on one page. The Schedule, containing SECTIONS I and I1 on page8 one through five.c. Attachment 1, Statement of Work, dated 5 July 1967, on thrcc pasib. ”&: .

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Aerospace Medical Division, Brooks A i r Force Bast, Texas 78235, undated, cC-. tai ning thirteen pages. (Copy for Contractor only). f . The General Provisions, AMSKR-1, dated 11 August 1967, consisting of

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rcsenrch tho biological effects of protons ' rqing Cron 32 Mcv t o 2.3ECV havcs'bcen studied i n Riicsus jjritaaics. Studics arc now ini progress to evaluate t h e effects of 5 i o 2Y' Mev protons and 1 to 6 '. the effects of spaco irrad:a;ion i n Ran. across the country to deternine whcther hmrn data i s available t o corral ate specific biological effects yi thc qo sure doses of c lcc tron irradiation. Theso visits were not satisfactory in that radiothcrzpy centers arc primarily i ater cst q + : i n tumor regression and puzo biological Ttic u1tic;tc aim, howevcr, is t o assess biological effects data fro: c,lcctron, exposures. This attempt was . ' I under t h e diroctiop af Dr. .Shi'al+ Wa.rr%n; Deaconess Hospital, Eosion, for th of all of 1967;',s,ubscqucnt meetinzs are ' to be held approxiiiwcly Tho objective of this $ozmiztce is t o obtain 'through thc course 0: rhreshold doses for various biolo&l effects in limans ~ XPOSC ~to dlc cr ron or proton therapy. In view of tho nature of ihc problem, the information will best, '0.c omrcssed as the concerted clinical opinion of a group of preimincntIy qu ali fid, practicihg p by s ici ~ r.. ~

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$1; the first meeting the contyaccor is .ti - out ii ne the objectives zez - tioncd' above. lhe comaittee msbcrs will discuss the hst possible I t is an ric irs tod t:'.3i tions on their radiotherapy patients .so that! i n subsequent xectings .. ncthods o f obtaining thc desircd informatioh. *Ill; Contractor will be respoqsible 'for the 'documentation of the dais Ihe contractor will be responsihlc t o furnish the mccting facilities. ilc will also furnish transportstion and per .dies expenses .for all microphoncs, etc., thcse, w i l i be supplicd by.:thc contractor. If special .eqaipnent is needed such as pro j Get or s, t o make a full recording of each session. Vithin the limits or" the funding for this work, ' tho contractor n-y t o docuncnt their dsta. "lhis could include'. such items as camr?.s; film, microscopes, special dyes, dosimetors, 'etc.

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the Armed Service6 Procurement Regulation (ASPR) are incorporated into Chis contract by reference with the same force and effect a8 though hcrcin s e t forth in full: S e provisions of the concrmc clauses 801: forth in the foiiowing paroerqpho O P ASPR Date of paratraph Clause Title 3 . 6-104.5 ' Buy American Act >:.3y 1 3 6 L 7-103.8 Assignment of Claims . I Feb 1962 .. ~ .it11.i9497-103.19 Officials Not to Benefit 9-102.2 Authorization and Consent Jan 156: 9-104 Notice and Assistance Regarding Patent , J a n 19G5 1-707.3 ( 6 ) Utilization of Small Business Concerns. ' 7-104.4 Kotice to the Government of Labor Disputes , si.:, ,1053 7-103.20 Covenant Against Contingent Fees 23, 1558 12-303 Contract Work Hotirs Standards Act-Overtime jx;i 1%; clause are deleted as not applicable) 7 4 0 2 . 4 Stzndards of Work .-7-203.7(5> Exanination of Records ..ov :gL2 11-7G4.i , , Termination for the Convenience o f the 3 x 1 1561

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Price Reduction for Defective Cost or Pyicing Subcontractor Cost and ?:icing Data Limitation on Withholding of Psyments General Services Administration Supply Sources Stop Work Order Reports of Work Limitation of Cost Service Contract Act of 1965

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to this ct n tract such releaseS hall include a statement t o the effect that the project or effort depicted wcs o r is sponsored by the agency set forth, in the Schedule of chis contzact. / (b) For the purpose of t h i s clause, "information" includes but is not limited to, news releases, articles, manuscripts, brochures, advertisements, still and motion pictures, speeches, trade association meetings, ments of the clause of this contract entitled "Military Security Require- (c) Nothing ir. the foregoing shall affect compli-ance with the require- (d) The Contractor further agrees t o include thik provision i n any subcontract awarded as a result of this contract.

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The Contractor shall, insofar as possible, svoid incurring ,a . direct or indirect costs i n duplicating work o r support capacity available at or through any Air Force installation involved i n the performance of t h i s tonzract or any major subcontract hereunder. Therefore, the contractor agrees - to utilize or cause t o be utilized all available Government or Government controlled working space, equipment, supplies, materials, services or other support (including communication services) a t or available through any Air Force Base, installation or office whtre work under this contract is performed. ule of this contract, such items will be made available i n reasonable amounts on a no-charge-for-use basis and the value thereof shall be apart of the consideration for this contract. tractors hall report any inadequacies or non-availability of items contemplated hereby together witha recommended plan for obtaining the requested item t o the Contracting Officer who shai: promptly deternine the validity a!d extent of …