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Oak Ridge Documents -z-/2+/.r9 "New biological problems are presented as fission the biological effects of these materials is urgently needed and these materials are now available in suitable quantity for experimental work. 3. Tracer experiments on humans t o determine % of Pu excreted daily. To be done a t Rochester. 5 none Memo - Stone t o Compton "Finishing Health Work of Metallurgical Project " should continue health research activities in spite of approaching end of war -- need t o provide safe standards for personnel producing Pu -- t o be based on experimental 4) "It i s planned here at Berkeley t o undertake, on a limited scale,a series of metabolic studies with Pu using human subjects " 6) "I believe that a few tracer studies both with human subjects and animals.. .should be made" Studies of acup & chronic radiation effects - external MED to help make arrangements for human tracer experiments. Suggest a hospital patient at Chicago or Rochester be chosen for injection with 1-10 pg Pu. Enclosing above memo; endorsing requests outlined ; urgency of exposure of workers makes it appropriate that MED consider medical problem more intensively than in past.
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PRIVACY ACT MATERIAL REMOVED Program to be carried out at Rochester. in future as in past j consist almost entirely of Dr. Bale and staff j work for MED as requested,including tracer him i n Berkeley area and continue collecting samples for Friedel l to Area Engineer, Berkeley Suggest purchase orders for specimens 8/ 17/45 Stone - Memo to Files Re: Warren's memo: Purpose and limitations of the Biological and Health Physics Program. p.2 - comment about moral responsibility of Univ. of Revised plan of Rochester Pu experiment sent to Bale "of course you and Friedel l will have final say"i 7y Specific proposals for national distribution of radioisotopes p.3 - statement re legal responsibilities for use of experimental material i n humans. Distribution only after approval by competent medical advisors and only toM.D. ' s associated with recognized 41 4/26/46 Friedel l to Warren proposed program a t Western Reserve University 1. Toxicity of thorium 2. Radiation tissue dosages - internally distributed PRIVACY ACT MATERIAL REMOVED
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5 13 1/46 Chapman to Peterson R e experimental program a t Western Reserve Univ. "Second objective would be incomplete without ,nclusion of Pu -- strongly opposed to introduction of Pu into for same reason. Disapproves support for proposed contract. Definite opinion for work a t Chicago 1/8/47 Kirk patri c (AEC field manager) t o AEC Berkeley "Administration of Radioactive Substances t o Human Subjects" Contractor t o submit program t o Commission for approval. 3/7/47 Burling t o Huddleson (AEC memo) ah:..V d View of legal division - all clinical testing to be done in relation to approved research program - must have proof that individual patient was informed of nature and possible risk of treatment and has expressed willingness On Dr. Warren's re com end ation you authorized omission to obtain written release" but urged certification by 2 doctors(in writing) of patient ' s state of mind and Authorized clinical programs a t Berkeley & Rochester only -- no others to be performed in interim period. classified "Secret" -- notto be released and have adverse effect on public opinion or result in legal suits. Further work has been prohibited by General Manager. The Experimental Use of Radioactive Materials i n Human Subjects at AEC Establishments Recommendations of Committee on Isotope Distribution Subcommittee on Human Applications (at request of Manhattan District History - Medical Program (No reference to human Pu work)