Supplemental Agreement - Contract No. at-(40-1)-263, University of Virginia, Modification No. 12

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University of Virginia 1960, by and between the UNITED STATES OF AMERICA (here in after called the "Government"), represented herein by t h e UNITED STATES ATOMIC ENERGY CCHOF THE UNIVERSITY OF VIRGINIA (hereinafter called the "Contractor") ; WHEREAS, the Government and the Contractor entered into Contract No. AT-(40-1)-263, dated April 1, 1949, providing f o r research and study of the effect of beta radiation on the distribution of phosphate i n red blood cells and i n cardiac muscle; and WHERWS, t h e contract has been amended heretofore by Modifications Nos. WHERFAS, the Commission desires to provide additional time for completion of the research described i n Supplement No. 11 t o Appendix "A", without addit ional funds, to obtain reports thereon, and to effect certain other changes as are here in after more particularly described; and WHEREAS, t h i s Supplemental Agreement is authorized by and executed under the Atomic Energy Act of 1954; NOW, THmEFORE, the parties hereto do mutually agree that said contract is hereby modified in the follow hg particulars, but in no others: 1. The following new section "12." is added t o Article 11: "12. The period during which the work under this contract may be conducted is hereby extended t o June 30, 1961." 2. The following sentence is added t o subparagraph 3.a. (4) of "Access to classified information other than Restricted Data shall not be granted unless the recipient possesses appropriate

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3 . Paragraph 16. of Appendix "B" is revised t o read as follows: "16. Use of Concerns i n Labor Surplus Areas It is the policy of the Government t o place supply contracts with suppliers who will perform such contracts subst anti ally in areas of current labor surplus where this can be done at prices no higher than are obtainable elsewhere. The Contractor agrees t o use its best efforts to place its subcontracts i n accordance with this policy tothe extent consistent with the efficient parformance of this contract. In complying with the foregoing, the Contractor, i n placing its subcontracts, shall observe the following order of a. small business concerns located i n labor surplus b. other concerns located i n labor surplus areas; c. small business concerns not located i n labor surplus 4. The following naw paragraph "17." is added t o Appendix "B'": "17. Use of Small Business Concerns a. It is the policy of the Government as declared by the Congress that a fair proportion of the purchases and contracts f o r supplies and services be procured from small business concerns. b. The Contractor agrees t o accomplish the maximum amount of subcontracting t o small business concerns that the Contractor finds t o be consistent with the efficient performance. of this and substitute there for in each instance the date "April 1". 6. In Appendix "C", delete the date "December l", and substitute therefor

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IN WITNESS WHEREOF, the parties hereto have executed t h i s Supplemental Agreement the day and year first above written. UNITED STATE3 OF AMERICA BY: UNITED STATES ATmIC ENQGY CCMMISSICN WITNESSES : THE RECTOR AND VISITORS OF THE ACCEPTANCE BY SENIOR INVESTIGATOR I have read the foregoing SuppT-eniental Agreement and agree t o be bound by the provisions of this document.

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University of Virginia by and betxeen the UNITED STATES OF MERICA 1tGovernwntH)9represented herein by tha UNITED STATES ATOYIC BJERGP CoYnSSION (here in after called the *Comais8ionm), and 7HE RECTOR AISD VISITORS OF THE UNIVERSITY OF VIRGINIA (hereinaftur called the *Contractor*); WHEREAS, the Oovwnment and the Contractor entered into Contract Ma, effect of beta radiation on th. dist ii but ion of phosphrt4 in red blood colla and in cardiac m cle ; a d WHEREAS, tho contract bs been rmendod heretafare by Modifleation8 Nos. RKSREAS, the Commi88iOn de8lres to prorid. far additional research 18 mare particularly desc rih d in Sopplentnt no. 11 to Appendix "Am, ta obtrh reparfa thereon, and to effect certain other change8 ad .re MreiMftuc more part icd a rly WHEREAS, thin Supplemntal Agreement is antharlsed by and emcutad der tho Atomic Ensrgy Aat of 19%; Nm, RIEREFORB, the parties hereto do mutually agree tihat said contract l r hereby modified in the following pr tic uh re,but in no others: 1. The following new section ull.ais 8dded to Article 11: m 1 1 . ' h e period during which the work under this contract may be conducted is hereby extunded t o Roverber 30, &960.* "i. I n consideration of the performance of th, additional work describod in Supplement No, 11 to Appendix "A*, and the Contractarts agreement to support that rat kin tK6 asti rated amount of fin Thotlsand, Six Hundred Ninety I)Oll6?8 ($10,690.00)~ the Government kill pay to the Contractat Bight Thousand, Eighty3. In subrections 2. a., 2. b. and 2. C. of Article 111, deleta the rmdr b. In subsection 2. d. of A r t i c l e 111, deleta the word "tern@and oobstlt u b therefar the word *rrorLr.

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TVare revised t o read a s follcnrs: *a. me Contractar agrees t h a t the Comptroller bneral of the United Stat as or any of hi8 duly anthoriaed representatives shall, until the expiration of three par8 after fiMl payment under thia contract, have access t o and the right t o examine any directly prtinent books, documenta, papers and records of the Contractor involving transactions related to this contract. ab. The Contractar further agrees t o include in all hi8 8ubcontPazd hereunder a provision t o the effect that the suboontractor ag?.ees that the Comptroller Osnsrrl of the United States or a q of hqs t o and the right to examim av directly pertinent boob, dacumenb, papers, and record8 of such subcontractor, involvtng tra ~ action8 contracts or purchase orders far public utility s9rrlces at rates eatablished for uniform app lica bil it ~to the gemral public; and (3) subcontracta or purchrse orders f o r g 0 1 ~ r l lImentarj! itom not specifically identifiable with the work under this contract.* 6. Article V is deleted in ita entirety, and the following new Article V it^ *In a a wide m tion of thb Contractarcs contribution ta the research materials, tools, machimry, eqnipent and, 8upplies acquired fiom a r q source, includiry the Oamrnmont, or MnufackPed by the Contractor undrr thi8 contract, shall m a t in the Contractor, except that title to item8 of property described i n section 2, b. of Appendix WAW shall rest or reMin i n th Oovermnt. Additional lbms may be added to such section 2. b. I n writing without ths necessity for afmal modification of the contract.' I n Appendix "F,paragraph 4. is revised ta read as follows:7. ma. Except as other rim provided i n this contZ.act, any dispute concerning a qWstlOn of fact 8ri8ixg Under this contract which is not disposed of by agreemnt shall be decided by the Contracting Officer, rho shall reduce his decision t o writing and milm otherwise fm ni rh8 Copy thereof to. the COUtr8ctor. The decision of the Contract- Officer shall be fiarl and toll~lusive,unlet~s, w i t h i n 30 days *om the &to of receipt of such copy, thb Contractor mails or othewiae- furnishes t o the Contracting Officer

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a written appeal addressed t o the Cammission. the Cammission or its duly authorized represent a tiw for the determination of such appeals shall be final and conclusirs unless determined by a court of competent Jurisdiction to have been fraudulent, or capricious, or arbitrary, or so grossly erroneous a s necessarily t o imply bad faith, or not supported by subst r nti al evidence. ing under this clause, the Contractak shall be affarded an opportunity t o be heard and to offer evidence i n support of its appeal, Pending final decision of a dispute hareunder., the Cont s actor ~ shal lproceed diligently with the performance of ths contract and i n accordance with the Contracting Officer's I n connection with any appeal proceed- %. This rMsputesg clause doe8 n o t preclude consideration of law questions i n connection with decisions provided f s in paragraph a.., above; Provided, that nothing in this contract shall be construed as makbg final the decl8ion of any ad n in is tra tim of fic lal, representative, or board on a question of law.0 8 . In Appendix wF,subparagraph 7. b. is revised to read as fol lars ? nbo The Contractor further agrees t o insert the faregoiag prori8ion in a l l subqoatrrcta horenMetr., except subcontracts for standard commercial supplies or raw materiale.* 9. I n Appendix "F,the second sentence of paragraph ll., Covrnrnt Again at Contingent ?eet~, Is rerised t o read as folluus: 'Far breach or rial ation of this warranty the Governnsnt shall have the right to annul this contra ot without lia bil it q or in it a discretion to deduct from the,cont s act price or conaideration, or othsrwise recowr, the f u l l amount of such conaission, percentage, brokerage, or contingent fee.^ 10. Ihe folluuing nerr paragraph w16.w is added i n Appendix "P: ~ 16. Placing clrders and Subcontracta-- with Fir as Located i n Areas of *It is the policy of the Qovwriment t o place supply contracts with supplier6 who will perform such contraat8 substantially in areas of current lab= surplus where this can bo do- a t prices no higher than are obtainable elsewhere. use its best efforts to place ita subcontracts and purchase orders in accordance with this policy t o the extent oonsistent with the efficient perfarmme of this contraot.' I h e Contractar agrees to

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11. The Supplement Ilo. 11 attached hereto and srde 8 p8rt hereof i s added TN WITNESS WHEREOF, the parties hemta ham execatad this Supplemental Agreement the day and year first rbom writtan. UNITED STATES OF AKERICA ACCEPTANCE BY SEWIOR IRvcsTIaATUR I hate read the foregoing Supplemental AgeePrsnt and ths Supplement l a . 11 attached hereto and made a part hereof and agreed t o be bound by the provisions of this document.

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This SUPPLEMWT NO. 11 describes the research program and cost estimates agreed upon between the Commission and the Contractor. a. Scope and Plan of Approachz Thedontractor will continue studies of the metabolic exchange i n isolated cell system of radioisotopes to in cl Me work on inorganic phosphate transfer into erythrocytes, using radioactive phosphorus, to follow the lead t h a t arsenate is a competitive inhibitor carried by the same mans of transport as phosphate, neu studies of erythrocyte ghost preparation, site of actLon of insulin and the cardiac glycosides, using 1-131 and C-l.4 labeling, effect8 of hulin on the glucose oxidat i o n in mannnalian erythrocytes, and related experiments. Effects of insulin on potassium transfer in muscle uill be studied with respect to ion transfer and using Kd,particularly to lead to a better understanding of the action of digoxin, deslanoside and ouabain, etc. of this work autoradiographic methods will be used, a. Oufline of Cost Estimatesr (1) Salaries and Uages: W-O,9OOo(30 Dr. D.R.H. Gourley (3 of time) 4,800000 Secretarial and Janitorial Aid 1,000.00 (3) Travel: hoo e oo (4) Overhead (38.34% of Salaries and Wages)t LJ79.00 bo Items of property to be procured o r manufactured by the Contractor, o r to be furnished by the Government, title to which will vest or remain in the Government (see Article V): None

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1959, by and between the WX'PGD 8lY~2EsOF AXEtIQ ( b m h f k r 01 (@1)-263. dated A p r i l 1, 19b9, providing for research and Studf af the effect af beta radiation on the distribution of pho8phate in rad blood cella and in cardiac musclej and m s , the Oovernmbrrt and the Cbntractor entered into Oontmct No. ATWHEItgAS, the contract has been amended heretafore by Hbdiflcrtions Nos. -8,' the &amladon desires t o provide f o r addiurnal remarch a8 more pn rUc ul.rly described i n Supplement No. 10 t o Appendix "AH, to obtaln repod thweon; and to effect cert a ln other C-08 8 8 me herolrmfter more particularly deecribed; and the Atondc lhsrgy Act of 195&; l e hereby modified I n the tollowlng particulars, but in no othorer WHEREAS, this Supplemental Agreement i e ruthorised by urd rxbcutsd under #3y, l!5lWORB, the parties hereto do mutuslly agree tbt raid contract 1. B e PollowLag new eection "10.n I s added t o Article a: period during which the work under t h l s contract may be conducted i s hereby extended t o November 30, 1S9.n I n conaidemtion of the p8rforsnance of the additionrl work der crib d in Supplenmnt Ro. 10 to AppndLx NAN, and the Contractor's agreement to support that m r k in the eat hated amount of 'Psn Thouuand, Three fhradmd Sirt)r - eight and &/lo0 Dollars ($10,368.%), ths Oommnt

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"a. On o r before the date of camnencemen+, of t h e work on the project described i n Appendix nAn, the G over m nt shall pay t o the Contractor upon sutard.ssion by t h e Contractor of a properly certified voucher, 45 per cent of "This SUPPLEMENT NO. 1 0 describes the research program and cost e s t i - mates agreed upon between the Conmrission and the Contractor. tra. Scope and Plan of Approach: me Contractor will continue studies of metabolic exchange in isolated cell systems to include completion o f earlier experiments in this area of study, particularly metaboli: interchanges at cell membranes, transport of arsenate and Phosphorus-32 labeled phosphates, c oncentra tiofi effects, the phosphorus carrier, effects of pH, role of APT, presence of APT in ghosts of er-Jthrocytes, role and movement o f potassium, utilizing Potassium-42 if possible, gain and loss of muscle potassium, effects of ouabain to separate effects of insulin on lactate oxidation and potassium uptake, and possibly the potassium turnover rat ds in muscle. "a. Outline of Cost Estimates: (1) Salaries and Wages: Secretarial and Janitorial

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1%. Items o f property t o be procured or manufaztured by the Cone acts r,title to which will vest i n the G over m nt (see I N WITNESS WHERECXF, t h e parties hereto have executed this Supplemental Agreement t h e day and year first above written. IJI:TNEsSEs: THE RECTOR AND VISITORS OF THE ACCEPTANCE By SENIOR INVESTIGA IDR I have read the foregoing Supplemental Agreement and agree t o b e bound by the provisions of this document. Senior Inv t' ator

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1958, effective as of December 1, 1957, by and betwe-e W I " Ed8 & OF AlERT CA (here in after called the wGovernmentw), represented herein by the WITED STATES ATOMIC ENERGY COMMISSIC?l (hereinafter called the "commissionw), and THE RECTOR AND WHEREAS, the Government and the Contractor entered i n t o Ccntroct No. …