Supplemental Agreement - Contract No. at-(40-1)-3853, Tulane University, Modification No. 4

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THIS SUFPLLWTAL AGREEMENT, entered into the28th day of February ,1972,effective the Is: day of December, 1971, by and between the LTITED STATES OF AMERICA (here in after referred to as the (here in after referred to as the "Commission"), and TULANE UNIVERSITY WHEREAS, the parties here to have heretofore entered into Contract No. AT-(b0-1)-3853 and Modifications there to numbered 1 through 3 provi ding for the Contractor ' s performance of certain research ; and WHEREAS, the parties desire to amend the contract f hrt her to provi de for the continuance of this research and/or the performance of additional research ; and WHEREAS, this Supplemental Agreement is authorized by the Atomic Energy Act of 1954, as amended, and S e c t i o n 3 0 2 ( c ) ( 1 5 ) of t h e Federal Property and Administrative Services Act of 1949, as amended; NOW, THEREFORE, the parties do mutually agree that the contract, as amended, is hereby further amended as follows: 1. I n ARTICLE I1 - THE PERIOD FOR PERFOFWINCE, the date November I n AF.TICL3 I11 - CONSIDERATION, the amcunt $62,800 is increased Appendix "A" applicable to the period indicated thereon. 4. In Appendix "B", the attached pages B-18 and B-21 dated 12-16-71 are substituted for the existing corresponding pages. change consists of the insertion of a new Article B-XXVI entitled %i liz ation of Minority Business Enterprises ," and the transposition of former Article B-XXVI, Soviet-Bloc Controls, to the position of

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IN WITNESS WHEREOF, the parties have executed this Supplemental UNITED STATES OF AMERICA t h e scope of its legal powers. IN WITNESS WHEREOF, I have of said Contractor. ed my hand and the seal

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TULANE UNIVERSITY CONTRACT NO. AT-(40-1)-3853 For the Contract Period October 1, 1971 through September 30, 1972. ARTICLE A - I RESEARCH TO BE PERFORMED BY CONTRACTOR The Contractor will continue studies of the role of the ret icu loen do the li al system inthe mama1 as a host defense mechanism, and with special attention to humoral recognition factors to determine (1 ) plasma humoral recognition factor in neoplasia, (2)characterization of the factor,(3) the influence of administration of the factor on leukemia, (4)role of the macrophages and macrophage RNA inthe imnune response, (5) characterization of the immunogenic RNA, with(6) an evaluation of the role of humoral recognition factors in antibody formation. The Principal Investigator,Dr. N. R. Di Luz io, expects t o devote approximately 12% ofhis time or effort to the project. ARTICLE A - I 1 WAYS AND MEANS OF PERFORMANCE (a) Items Included in Total Estimated Cost: P r inc ipa 1 I nves t iga tor (3) Supplies and Materials : 5,573 Experimental animals, animal food and care, glassware, chemical s , and radiochemical s . (4) Equipment t o be Purchased or Fabricated0 by the Contractor : a- Equipment Estimated t o Cost Less than $1,000: -b Equipment Estimated t o Cost i n Excess o f $1,000: Reprints, books, laundry services,repair of scientific equipment, etc.

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(7) Indirect Costs(Fixed a t 49.6% of Salaries & Wages): Items, i f any, S iq n if i cant to the Performance of this Contract, but Excluded from Computation o f Support Cost and from Consideration in Proportioning Costs: (1) Items t o be Contributed by the Contractor : Items t o be Contributed by the Government: None under this paragraph ARTICLE A-I11 The total estimated cost of items under A - I1(a) above for the contract period stated in this Appendix " A " i s $29,693; the Bmmission will pay 65% of the actual costs o f these items incurred during the contract period stated in this Appendix "A", subject to the provisions of Article I11 and Article B - XXVII. The estimated AEC Support Cost for the contract period stated in this Appendix "A" i s

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other areas sf the United States,respectively,or(2) are non certified concerns whizh have agreed t o perform substantially in per si sent or substantial Labor surplus areas, where this can be done consistent with the efficient 2erformance of the contract and at Ij rices no higher than are obtair.a'cle eisewhere. The Contractor agrees t o ilse its best efforts t o place i+,s s-Lbcontracts i n accordance with this policy. paragraFn (bj of the article of this contract entitled " Utilization of Small Business Concerns" the Contractor in plac ic gits subcontracts shall observe the fo1lowir.g order of preference : (1) Certified - eligible concerns with a first preference which are also small business concerns; fied - eligible concerns witha second preference which are also small business concerns; (4) other certified - eligible concerns witha second preference; (5)persistent or substantial labor surplus area concerns which are also small business concerns; (6) other persistent or subst anti al labor surplus area concerns; and (7) small business concerns which are not labor surplus area concerns. In complying with paragraph (a)of this article and with ARTICLE B-XXV - UTILIZATION OF SMALL BUSINESS CONCERNS (a) It is the policy of the Government as declared by the Congress that a fair proportion ofthe purchases and contracts for supplies and services for the Government be placed with small business concerns. (b) The Contractor agrees to accomplish the maximum amount of subcontracting t o small business concerns that the Contractor finds t o be consistent with the efficient performance of this contract. ARTICLE E-XXVI - UTILIZATION OF MINORITY BUSINESS ENTERPRISES (a) It is the policy of the Government that minority business enterprises shall have the maximum practicable opportunity to part ici - pate in the performance of Government Zontracts. (b) The Contractor agrees to use its best efforts to carry out this policy in the award of its subcontracts to the A"uliest extent consistent with the efficient performance of this contract.As used in this contract, percent of which i s owned by minority group members or,in case of publicly owned businesses, atleast51percent of the stock of which is owned by minority group members. group members are Negroes, Spanish-speaking American persons, AmericanContractors may rely on written representations by subcontractors regarding their status as minority business enterprises in lieu of an For the purposes of this definition, minority

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of the research work without dlr ect ion by ar, ar;proved principal invest i gst cr. ,'ne a rinc i pal investigator my increase or decrease tai ning Cocmisslcr, apFmsral; however, the principal is vest i gator sent at ive if ne rl an st c,or beccimes aware that he will, devote substantially ies s effort to the work than anticipated in Article A - I . The purpcse cf such consultation will be t o determine what effect,if any, zh?e anticipated change will have on the research (b) No change inthe phenomenon o r phenomena under study; i.e., broad category of the research under this contract,shall be made without the specific written approval of the Commission; ordinarily, such changes, i f apprcved by the Commission, will be accomplished through a new contract 3r a mutually agreed-to modification. The Contractor may change the specific objectives in the research work described in this contract, provided it gives the Commission prompt notification of such changes; and the Contractor may continue t o follow the new objectives while the Commission determines whether it wishes to continue the program under the changed approach. I n connection with the contract activities,the Contractor agrees t o comply with tne requirements set forth in Appendix "D" of this contract relating to the cx n tries listed there in. From time to time, by t o change the listing of countries in Appendix "D" upon a determination by the CommissLJn that such change isin conformance with national ance under this conLract upmat least sixty(60) days' prior written without substsn:i&ly ir ze rf eric g with its policies as an educational institution or without & verse ly affecting its performance, t o continue performance of the vs r km der this co c tract as are suit of a change i n Appendix I'D" made by tne Commission pursuant to the preceding sentence. If the Ccntrac5sr ei ect s to terminate performance, the provisions of this contract respect1r.g termination for the convenience of the Governnent shall apoly . The Zon:raczsr shall ha;re the right to terminate its perform-

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THIS SUPPLEMENTAL AGREEMENT, entered into the17th day of December , 1971, effective the 1st day of October, 1971, by and between the UNITED STATES OF AMERICA (here in after referred to as the "Government"), as represented by the U. S. ATOMIC ENERGY COMMISSION (here in after referred to as the "Commission"), and TULANE UNIVERSITY WHERF,AS, the parties here to have heretofore entered into Contract No. AT-(40-1)-3853 and Modifications there to numbered 1 and 2 providing for the Contractor ' s performance of certain research ; and WHEREAS, the parties desire to amend the contract f luther to provide for the continuance of this research and/or the performance of additional research ; and WHEREAS, this Supplemental Agreement is authorized by the Atomic Energy Act of 1954, as amended, and S e c t i o n 3 0 2 ( c ) ( 1 5 ) of t h e Federal Property and Administrative Services Act of 1949, as amended; NOW, THEREFORE, the parties do mutually agree that the contract, as amended, i s hereby further amended as follows: 1. I n ARTICLE I1 - THE PERIOD FOR PERFORMANCE, the date September I n ARTICLE I11 - CONSIDERATION, the amount $58,000 i s increased 3. Appendix "A", attached here to,shall constitute the Contract Appendix "A" applicable to the period indicated thereon. 4. In ARTICLE I V - ADDITIONAL CONTRACT PROVISIONS, t h e Appendix of the effective date of this modification. attached here to is made applicable to the contract effective as

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I N WITNESS WHEREOF, the parties ha-e executed this Supplemental STATES OF AMERICA S. ATOMIC ENERGY COMMISGION Laboratory and Unhrenity Divb&n TITI.23: Business Manager and Comt roller of the Contractor named under this contract ; that who signed this contract on behalf of said Contractor was then of said Contractor; that said contract was duly signed for and on behalf of said Contractor by authority of its governing body and is within the scope of its legal powers. I N WITNESS WHEREOF, I have hereunto affixed my hand and the seal of said Contractor.

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TULANE UN I VERS ITY CONTRACT NO. A T - ( 4 0 - 1 ) - 3 8 5 3 For the Contract Period October 1, 1971 through November 30, 1971. The Contractor will continue studies of the role of there tic u loen do the li al system i n the mama1 as ahost defense mechanism, and with special at tent i or t o humoral recognition factors to determine (1) plasma humoral recognition factor in neoplasia, (2)characterization of the factor,(3)the influence of administration of the factor on leukemia, (4)role of the macrophages and maqrophage RNA inthe imnune response, (5) characterization of the immunogenic RNA, with(6) an evaluation of the role of humoral recognition factors in antibody formation. The Principal Investigator, Dr. N. R.Di Luzio, expects t o devote approximately 15% of his time or effort to the project. ARTICLE A - I 1 WAYS AN0 MEANS OF PERFORMANCE (a) Items Included In Total Estimated Cost: Salaries and Wages: Supplies and Materials : Experimental animals, animal food and care, glassware, chemicals, and radiochemical s. Equfpment t o be Purchased o r Fabricated by the Contractor : a Equipment Estimated to Cost Less than $1,000: b- Equipment Estimated t o Cost i n Excess o f $1,000: Reprints, books, laundry services, and repair of

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TULANE UNIVERS ITY 2 CONTRACT NO. AT-(40-1)-3853 (7) Indirect Costs(Fixed at49.6%of Salaries & Wages): $1,923 (b) Items, i f any, S iq n if i cant to the Performance of this Contract, but Excluded from Computation o f Support Cost and from Consideration in Proportioning Costs: (1) Items t o be Contributed by the Contractor : (2) Items t o be Contributed by the Government: None under this paragraph ARTICLE A-I11 The total estimated cost of items under A-I1 (a) above for the contract period stated in this Appendix "A" i s $7,549; the Comnission will pay 64% of the actual costs o f these items incurred during the contract period stated in this Appendix "A", subject to the provisions of Article for the contract period stated in this Appendix " A " i s The estimated AEC Support Cost

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o r an.y duly au th xi zed represec'ative there of,icc lu ding the contracting officer, except for the 3iL:';ose of deciding a?. ages; under ',ne article contract on behalf c? tne GoTrernmens and includes his successors o r any duly aLthorlzed re pre senza tl ve of any such person. (c) Except as ct her wise grovided in this contre xt, the term "subcontracts " includes purchase orc?ers under +,his c oz tract. (a) Tie Conmission shall have the right to inspect,in such manner and atall reasonable times as it deems appropriate,all activities of the Contractor arising in t ne course of its undertakings under this (5) The Contractor snall make gr ogress and other reports in such manner acd a t such times as specified in Article 3-XXI. me Contractor shall also make such other reports to The Commission, with respect to its activities under t kl s coE tr & ct, as the Commission nay reasonably require from time to sine. (c) Tne Contractor agrees to keel, records ar?d books of accour,t, ir, accordance w-lth gec e rally accepted accouming principles ani pac - as const it x ted on +-he effective comezcenect 2ate of the contract Article A-II:2) o l P-?per,dl:; "A" arid which are inPut her axe of the research work under this contre ct. In %he event a contractor con tri - records adequate to per xt the Commission t o determine the extent of the contribution.If2r of ess ional st tiff members are incl-ided under nelin accordance witk +,he Dayroll distribution procedure of sect i or, (a) The Comission shall at all reasonable tines be afforded acces s to the premises and to these books and records and tc related correspondence, receir;:s, vouchers, memoranda, and other data of the Contractor; and the Contractors hall preserve such books ar*d papers, without additional compensation there for,for a period of three(3) years after comgletion of this contract.

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available to all ttrougri zcrma: m d acce-,:ea chancels without rest ric - of 1954, as arnefided, CY ot ker c less ff i ed lxf3rmatiori shall be disclosed article is publish ec acd f'irzis:? si:.: (6)m pies of the article as (b) It i s recogclzed that dlz-izg the course ~f the work hereunder, tors, may from time to time desire ;c ~ u blis h ,w ithip the limit of security require me rts,in for nat i or.regarding technical or scientific developments arisi2g in the ccw se of the contract. In order that public …