Supplemental Agreement - Contract No. at-(40-1)-2081, University of Florida, Modification No. 3

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University of Florida THIS SUPPLEMENTAL AG€EEMENT, entered into this day of ~anu;uv~ l960, by and between the UNITED STATES OF AldERICA (here in after called the "Government"), represented here in by the UNITED STATES ATCUIC ENERGY CCWISSION (hereinafter called the "Commission"), and STATE BOARD ACTING FCR AND I N BEHALF OF THE UNIVERSITY OF FLORIDA (here in after called WHEREAS, the Government and the Contractor entered i n t o Contract No. AT-(h&l>-2081, dated October 11, 1956, providing fora study of the biochemical results of certain treatments given patients suffering from phenylpyruvic acid oligophrenia; and MHW, the contract has been amended heretofore by Modifications Nos. 1 and 2; and lJHEMUS, the Cammission desires to provide additional time for comple tion of the research described in Title I11 of Appendix WA", without additional funds, t o obtain Feports thereon, and to effect certain other changes as are hereinafter more particularly described; and WHEREAS, this Supplemental Agreement i s authoriced by and executed under t h e Atanic Energy Act of 19%; NOW, 'IHEXEFORE, the parties here to do mutually agree that said contract is hereby modified i n the following particulars, but i n no others8 1. The following new Section h. is added to Article 11s nh. The period during which the work under this contract may be conducted is hereby extended to January 319 1960." 2. I n subsections 2. a., 2. b e and 2. C. of Article In, delete the words "properly certified voucher" and substitute therefor the words nproper voucher". 3. I n subsection 2. d. of Article 111, delete the word V,erm" and subst it ute therefor the word mworkn. Article IV are revised t o read as follows: "a. The Contractor agrees that the Comptroller General of the United States or any of his duly authorized representatives shall,until the expiration of three years after final payment under this contract, have access t o and the right to examine aqy directly pertinent books, documents, papers and records of the Contractor involving transactions related to this contract.

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Ilb. The Contractor further agrees t o include in all his subcontracts hereunder a provision t o the effect that the subcontractor agrees that the Comptroller General of t3e United States or any of his duly authorized representatives shall, until the expiration of three years after final payment under the subcontract, have access t o and the right to 'examine any directly pertinent books, documents, papers, and records of such subcontractor, involving transactions related to the subcontract, The term 'subcontract' as used i n this clause excludes (1) purchase orders not exceeding $2500; ( 2 ) subcontracts or purchase orders for public utility services a t rates established for uniform applicability to the general public; and ( 3 ) subcontracts o r purchase orders for general inventory items not specifically identifiable w l th the work under this contract. 5.Article Vis deleted in its entirety, and the followinp; mw Article "In consideration of the Contractor's contribution t o the research project described i n ADpendix "A'' of this contract, title to all materials, tools, machinery, equipment and supplies acquired from arry source, including the Government, or manufactured by the Contractor under this contract, shall vest in the Contractor, except that title to items of property described i n Section 2. b. of Appendix "AI' shall vest o r remain inthe Government. items may be added .to such Section 2. b. i n writing without the necessity fora formal modification of th contract." 6. In Appendix "B", Paragraph h. i s revised t o read as follows: "a. Except as otherwise provided in this contract, aqr dispute concerning a question of fact arising under this contract which i s not disposed of bv agreement ' shall be decided by the Contracting Officer, who shall reduce his decision t o writinrr and mail or otherwise furnish a copy thereof tothe Contractor. The decision of the Contracting Officer shall be final and conclusive unless, within.3 days fr m the date of receipt of such copy, the Contractor mails or otherwise furnishes t o the Contracting Officer a written appeal addressed tothe Conmission. The decision of the Commission o r its duly

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authorized representative f o r the determinaticn of such a peals shall be final and conclusive unless determined by a court of competent jurisdiction to have been fraudulent, o r capricious, o r arbitrary, o r so grossly erroneous as necessarily t o imply bad faith,or not supported by substantial evidence. connection with any appeal proceeding under this clause, the Contractor shall be afforded a n opportunity t o be heard and to offer evidence i n support of its appeal. Pending final decision of a dispute hereunder, the Contractor shall proceed diligently with the performnce of the contract and i n accordance with the Contracting Officer ' s decision. lib. This 'Disputes' clause does not preclude consideration of law questions i n connection with decisions provided forin Paragraph a., above; Provided, that nothing i n this contract 'shall. be construed as making ff nal the decision of any administrative official, representative, o r board on a question of law. 7. I n Appendix llBlt, the second sentence of Paragraph 7., Covenant Against Contingent Fees, i s revised t o read as follows: "For breach or violation of this warranty the Government shall have the right to annul this contract wit i out liability or in its discretion to deduct from the contract price or consideration,or otherwise recover, the full amount of such ccmmission, percentage, broker as, or c ontinqen tfee 8. I n Appendix vrBrr, subparagraph 11. b. i s revised t o read as follows: "b. The Contractor further agrees to insert the foregoing provisions in all subcontracts hereunder, except subcontracts for standard commercial supplies or raw materials." 9 . 'he following new Paragraph 16. is added i n Appendix nBnt "16. Placing Orders and Subcontracts with Firms Located i n Areas of Substantial Labor Surplus It isthe policy of the Government t o place supply contracts with suppliers who will perform such contracts substantially in areas of current labor surplus where this can be done a t prices no higher than are obtainable elsewhere. The Contractor agrees t o use its best efforts to place its subcontracts and purchase orders i n accordance with this policy to the extent consistent with the efficient performance of this contract.I1

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I N WITNESS WEREOF, the parties hereto have executed this Suppleaental Agreement the day and year first above written. UNITED STATES OF AMERICA BY: UNITED STATES ATOMIC ENERGY COMMISSION STATE BOARD OF CON'ROL, ACTING FOR AND I N BMALF OF THE UNIVERSITY OF FLORIDA ACCEPTANCE BY SENIOR INVESTIGATm I have read the foregoing Supplemental Agreement and agree t o be bound by t h e provisions of this document.

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Univaraity of Florida THIS -A& Am, entered into this2 ovember 9 1958, by and between the UNITED STITES OFllywICA (hem after cane: the Wovernwntm), represented herein by the UN lTS D STATES ATOMXC EHBMT COyyI59lOlf AND IN BEHAIF OP THE UNI Vl RSI TY OF Fu]RIDA (here in after called tb Wontractarm); WHEREAS, the Governmbnt and the Contractor entered i n t o Contract No. AT- (40-1)-2081, dated October 11, 1956, providing f o r a study of the biochsnical resalts of certain treatments given patients suffering from pbs q yl ml c acid WEREAS, the Contract has been amnded hsretofore by Modification No. 1; and e,the Comission desires to provide far additional research a8 more particularly described in T IT IS III of Appendix RAW, t o obtain report8 thereon, and to effect certain other changes a s are here in after more particularly described; and WHEKMS, t h i a Supplemsntal Agreement is authorized by and executed under the Atomic Ibnergy Act of 19%; NCIII, TIERIFORE, the parties hereto do mutually agree that said Contract i r hreby modified i n ths following particulars, but i n no others; 1. The following new section 5." is added t o Article I: "5. The Contractor shall commence the work a s soon as feasible, prosecute it with due diligence and submit the reports required hereunder as early a8 practicable, and not l a t e r than the dates specified in Appendix "C*.W and the following new section * 3.m is added to Article 11: "3. The period during which t h e work under t h i s contract may be conducted is hereby extended t o August 31, 1959mn 3. The following new subsection "1. c o n is added i n Article 111: IC. In consideration of the performance of the additional workdescribed i n TITLE I11 of Appendix RAW, and the Contractor's agreement t o support tht work i n the estimated amount of Six Thousand, Three Hundred Sixty-three Dollar8 ($6,363.00), the Oovernmont rill pay t o the Contractor Fifteen Thousand, W t o be the balance remaining unexpended from previous work under this Contract)." This Contract has been approved by the Attorney General as per h i s stamp

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4. Subsection 2. a. of Article 111 is revised t o read as f Oll cm8t "8 dn or before the date of conmencemnt of the work on tt m project described i n Appendix "Am, the Oorsrnment shll pay t o the Contractor upon submission by the Contractor of a properly certified vouchcr, )& per cent of the agreed consideration; podded, hmever, that this paymsnt shall be reduced by t h e amount of the balance agreed to be rePaLning unexpended f'rom p.claoua work 5. In subsection 2. C . of b tic le 111, delete the word *tern* and sub6. Section 3. of Art icl s XI1 is revised to read a s folltmr: When renewal o f the contract is desired, ths Contractar shall sublnit t o the Comnission's Oak Ridge Operations Office a r8rrerr.l proposal a8 aut lim d in Appendix *Cn attachsd hereto. negotiate asto theramounta each rill contribute far tha additional research actirities t o bc canducted, taking into consideration the actual co8ts incurred for the current work h conparison rith ths cost estimates in the contract, and, upon agreement, shall execute a formal modification of ths contract." 7. The following nem TI= m I I T n is added in Appendix "Am; "This TITLE 111 describes t h e research program and Cost estimates agreed upon betwee. ma. Scope and Plan of Approach: The Contractor will continue studies,in coop ration with the Sunland Training Center (formerly called the Florida Fua Colony), a State of Florida institution,to evaluate from the biocherical viewpoint corpyruvic acid oligophrenia. of the patients will continue, the sampling of urine being required i n order to follow the met.bolic patterns invohred in the patients. studies rill be carried out util is Lng Carbon-l& labelled phenylpyruvic acid and phenylalanine, and t h e program will probably be extended i n t h e study of the breakdown pattern of the metabolism t o include CarbonIt, labeled pyridoxine and t To s be,with due attention to age of patient. An extensive samplirg program with recording

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ma. Outline of Coat Batlmates: (1) Salaries and Wages: r) 9,%3.00 Research Aasistsnta and Technicians 5 9 3 3 0 . 0 0 (2) Squipabnt and Supplies: 5,m.Oo (4) Overhead ( 6 . 9 3 % of salaries charged t o the Comnisaion): 5,Ss.OO +It ie recognized that the project may receive additional financial sop Ttens of property t o be px u red or manufactured by the Contractar, title t o which rill veet inthe Government (see Article V)r part aa described in the renewal proposal. 8. Appendix NC" is deleted in its entirety, and the new Appendix Wm attached hereto and made apart hereof is sub rt it u ted therefar. I N UITNBSS mF,the parties hereto have executed this Supplelpsntpl Agreement the day and p a r first above writ'ten. UNITED STATES OF AMERICA

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I have read the foregoing Supplemental Agreement and the Appendix "Cm attached hereto and made a part hereof and agree t o be bound by the provisions of this documnt.

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REWRTS AND PROPOSALS (FOR DIRECT AEC RESEARCH CONTRACTS) Renewal Proposal six and scope with submittal date Complete Scientific Report On contrast expiration or Radioisotopes Purcha se Tith renewal proposal i f Three Report ' proposal i s submitted, otherwise on contract expiration Brief reports o r manuscripts may be submitted as desired by All of the above should be addressed to: Research and Development Division Oak Ridge Operations Office Post Office Box E Oak Ridge, Tennessee me progress report should briefly describe the scope of investigations undertaken and the significant results obtained. between the actual level of activity (expressed i n the various categories of man-months, facilities procured, travel performed, etc.) and that contemplated i n the contract. Technical reports and articles prepared for publication & odd be listed with bib lio - material contained there in need not be duplicated inthe report. It should also explain any significant dirferences Reprints or pre prints of all such material should be appended and Renewal proposals, if any, should accmpany the progress report and should contain the type of information outlined below unless the information i s already contained i n earlier proposals or inthe accompanying progress report. program or scope for the additional work should be clearly explained and the cost estimated should be based upon past experience. Any contemplated change i n

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Title of the project. The institution and department i n which the work will be done. Scientific background including literature relevant t o the proposal, the significance ? and the motivation. work already i n progress the extent of present support should be stated identifying amounts received fram federal agencies. If the proposal isfor continuation of Scientific scope of the proposed research, its objectives, its relation to present knovledgs and t o comparable work i n progress elsewhere, and a plan of accomplishments for the work. Scientific Personnel. Give the name, highest academic degree, position in the institution,scientific experience ,, publications and accomplishments of the SerLor In-restigator (the individual who will actively direct the research program) and of each regular staff scientist who it i s proposed will engage i n the work. Indicate the approximate fraction of the time of each t o be devoted t o the project. project should be so designated, and professional records given i f possible. Scientific personnel t o be newly employed for the Other hrs on nei. The number of persons of each sub-professional grade and the fraction of the time of each t o be devoted t o the project should be t nes is is t o be rela*ted t o the project. Graduate student employees should be identified as such if their Other Financial Assistance. If assistance for #is or other activities involving the same personnel or facilities is to be proposed to,or received from other federal or non-university sources the extent of that …