Supplemental Agreement - Contract No. at-(40-1)-2026, Wally Bohannon-Hodgkin's Research Foundation, Modification No. 1

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Wallg Bohannon-Hodgkin's Research Foundation 1956, by and between the UNITED STATES OF aMERIcI (hereinafter c a l l e represented herein by t h e UNITED STAT&S ATQI~IC GNWGP COMMISSION WHIBE&S, the Government and the Contractor entered i n t o Contract No, AT-(40-1)-2026,' dated January 14, 1956, providing f o r radioisotope studies in wHEBE4So the parties hereto desire t o provide for increased activity of the research activities previously undertaken by providing for an increase of the Government's contribution t o said research activities, and to effect certain other changes as are hereinafter more particularly described; and under the Atomic Ene ~ g yA c t of 19%; WHERE&S, t h i s Supplemental Agreement is authorized by and errrecuted NOW, THB WORE, the parties hereto do mutually agree that said amI n subsection 1, a, of Article 111, the ammnt Twelve Thousand, tract is hereby modified i n the following particulars, but i n no others: Fffty Dollars ($12,050.00)~ is deleted, and the amour&, Vourteen Thousand, Sfx Hutxired Fifteen Dollars ($l4,61S.oO)fl is inserted i n Ueu thereof, 2o I n subsection 2, a. of T IT IEI of Appendix "A", the amount '899OOoOO" for budget i t e m ( 2 ) Supplies and Equipment is deleted, and the amount fW.94650Wwis inserted in lieu thereof. 30 I n subsection 2. a. of TITLE I of 4pe.ndbt "An, the amount "$%,214040a designated as the VOTAL" is deleted, and the amount q36,779.40m is inserted in lieu thereof.

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IN WITNESS WHEREOF, the parties hereto have executed t h i s Supplemental eee ment the day and year first above written. UNITED STATES OF AMERICA WULY B(XAI?NON40DGKIN1S RESEIRCH FOUNDATION ACCEPTANCE BY SENIOR INVESTIGATOR I have read the foregoing Supplemental Agreement and agree t o be bound by the provPsfms of this document.

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THIS CONTRACT, entered into this = day of Janurry , 1958, effective as of November 1, 1955, by and between the UNITED STATES OF AKEFUCA (hereinafter called the ltCaoernmentn), acting through t h e UNITED STATES ATOXIC Ell'ERGT tXHMISSI(34 ARTICLE I - PURPOSE AND SCOPE 1, The Com@ssion, i n furtherance of i t s policy of assisting and fostering private research, desires t o support the Contractor's fundamental research in t h e field of atomic energy. 2. 21revork s h a l l consist of research by the Contractor involving radioisotope studies i n Hodgkin's Disease. agreed upon program and budget for the pmject are described i n Appendix "A", which i s hereby made a part of this contract. The Contractor shall be guided by, but not bound t o conform to the details of, the budget described i n Appendix I1An. The plan of approach tothe problem and the 3 . The Contractor shall furnish all services, facilities, equipuent, supp l i e s and materials (except,such services, equipment, supplies and materials as the GovenuBent has agreed t o furnish herein) required for t h e performance of the research program described i n Section 2. above. 4. The work w i l l be carried out by the Contractor under t h e direction of Dr. Jack M. Rose as Senior Investigator. 1. The initial period of performance for the research project covered by this contract will commence on November 1, 1955, and will end on October 31, 1956. i s recognized that completion of the research work under this contract may involve a period of several years and that the term of this contract may be extended by a. I n consideration of the performance of the research activities described i n Title I of Appendix "An, and the Contractor's agreemnt t o support

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that worn i n t h e estimated amount of Twenty-two Thousad, One Hundred Sixtyfour and i+O/lOO Dollars ($22,164.40), the Government will. pay tothe Contractor for the first period of performance the sum of Twelve Thousand, Fifty Dollars a. On or before t h e date of comencanent of work on t h e project described i n Appendix 'AH, the Government shall pay t o the Contractor upon submission by the Contractor of a properly certiiYed voucher, 45 per cent of t h e b. On o r before t h e expiration of sbc months from the date of canmencement of t h e project, the Gmemment shall pay t o the Contractor, upon submission by the Contractor of a properly certified voucher, 45 per cent of the C. Upon receipt and acceptance of a satisiactorg progress report, in cases where the contract isto be renewed, or the final report ifthe ccntract is not t o be renewed, the Carrernment shall pay t o the Contractor, upon suba3ission by the Contractor d a properly certified voucher, the rensining 10 per cent of the agreed consideration, An ex tens la of the contract ten with& additional funds shall not be considered a renewal of the cm tract and i n such cases t h e retained 10 per cent of the agreed consideration w i l l be paid upm submission and acceptance of a satisfactorg Mnal report, d. In the event the contract is renewed, payments tothe Contractor of any additional amount t o be paid by the Government s h a l l be made for the extended term i n accordance with the schedule out;llned in Paragraphs a., b., and c., above. 3. ProRram and Budget for Subseauent Periods When renewal of the contract i s desired, the Contractor shall submit t o the Connnissionts Oak Ridge Oprations Office a renewal proposal as outlined in Appendix "C", attached hereto. negotiate a8 tothe amounts each will contribute for the services t o be performed during the ensuing period, taking i n t o consideration the actual costs incurred during the current period in comparison with the cost estimates in the contract, and, upon agreement, shall execute a formal modification of t h e ccntract. The Contractor and the Comnission shall then

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ARTICLE IV - REPaRTS, RECORDS AND INSPECTION 1. The Commission shall have the right to inspect i n such manner and a t such times as it deems appropriate all activities of the Contractor arising in the course of the work under this contract. 2. The Commission shall at all times be afforded access tothe premises and t o all technical records, correspondence, instxuctions, drawings and memoranda of record value of the Contractor pertaining 3. The Contractor shall make progress and other reports i n such manner and a t such times 'as specified i n Appendix "C" which is attached and hereby made apart of this contract. 4. Examhation of Records a. The Contractor agrees that the Comptroller General of the United States ar ~ Q T of his duly authorized representatives shall have access t o and the right to examine any directly pertinent bqoks, documents, papers and records of t h e Contractor involving transactions related t o this contract until the expiration of three years after final payment under this contract . b. The Contractor further agrees to include in all his subcontracts hereunder a provision to the effect that the subcontractor agrees that t h e Comptroller General of the United States o r any of his duly authorized representatives shall have access t o and the ribt to examine a r ~ yd i rect ly pertinent books, documents, papers, and records of such subcontractor involving transactions related to the subcontract until the expiration of three paps after final payment under this contract. The term ffsubcorrtract" as used hemin m e a n s any purchase order o r agreement t o perform all or any part of the

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work or t o make o r furnish any materials required for the performance of this contract, but does not include (1) purchase orders not exceeding $l,OOO, (2) subcontracts o r purchase orders for public utility services at rates established for uniform applicability tothe general public, or (3) subcontracts o r purchase orders for general inventorg items nut specifically identifiable wtth the work under this contract. c. Nothing in this contract shall be deemed t o preclude an audit by the General Accounting Office of any transaction under this contract. ARTICLE V - TITLE TO PROPERTY PURCHASED BY CONTRACTOR In consideration of t h e Contractor's contribution t o the research project described i n Appendix nA1l of this contract, title to all materials, tools, machinery, equip nt and supplies, acquired from any source including the Government, or Icanufactumd by the Contractor under this contract shall vest in the Contractcr, except that title to items of property described i n Section 2. b. of Appendix "An shall vest inthe Govenunent. 1. The Contractor shall purchase, t o the extent available h appropriate form, all radioisotopes, irradiation services and cyclotron time required in the performance of the work hereunder, through the Commissionls Isotopes Division, Post Office Box E, Oak Ridge, Tennessee. 2. I f any radioisotopes are budgeted inthe outline of cost estimates a t the full amount ofthe price as established by the Coarmission, but are purchased at less than such established prices under an AEC Discount Certificate issued t o the Contractor (See: Title 10 C.F.R., Part 37), then any difference between the established price and the price so paid shall be paid by the Contractor tothe Govemment or otherwise credited t o the Government's account as t h e Contractbg Officer may direct or approve. The requirement fora report t o be submitted t o the Commission indicating the purchases under the discount program i s outlined The provisions of Appendix sB1lattached hereto, are hereby made a part of this contract. The following alterations to this contract were made by mutual agreement of the parties prior toits execution: None.

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IN WITNESS WHEREXlF, the parties hereto have executed this contract the day and year first above written. UNITED STATES OF AMERICA BY: UNITED STATES ATOW ENERGY COMMISSION Direktor, Contract Mvision, OR0 ACCEPTANCE BY SENIOR INVESTIGATOR I have read the foregoing contract and the Appendices attached hereto and made a prt hereof and agree to be bound by the provisions of t h i s document.

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This TITLE I describes the research program and coat estimates agreed upon between the Conmission and the Contractor for the first period of performance. The Contractor proposes t o study the fate and metabolism of the globulin fraction of rabbit anti-Hodgkin's disease serum in the body of the human, studying blood disappearance, urinary levels, uptake levels in various parts of the body *en the material i s tagged with Iodine-131 radioactive include autoradiogra@y, studies of centrifugally-sewrated f ractlons, and studies on excised tissues. Jefferson Davis Hospital, Baylor Univ. College of Medicine, arxi the Veterans' Hospital dll be available to facilitate the work, and the'basic studiea will be conducted i n t h e laboratories of the Wally Bohannan-Hodgkinls Research Fowdation, t h e Contractor. Specificity studies will be made on the factor, and the work will Facilities of the Methodist Hospital, a. Outline of Cost Estimates for the First Period: (1) Salaries and Wanes: (2) Supplies and Eauipment: 8,900.00 *Private physician, not salaried by Foundation. b. Items of property to be procured or manuf'actured by the Contractor during this period, title to which will vest in the Government (see Article V):

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(FOR DIRECT AEC RESEARCH CONTRACTS) a. Whenever any invention or discovery is made or conceived by the Contractor o r its employees i n the course of, i n connection with, or under the terms of this contract, the Contractor shall furnish the Commission with complete information thereon; and the Commission shall have the sole power t o determine whether or not and where a patent application shall be filed, and t o determine the disposition of the title to and rights under any application o r patent that may result. shall be accepted a s final; ard the Contractor, for itself and for its employees, agrees that the inventor o r inventors will execute all documents and do a l l things necessary or proper t o carry out the judgment of the Commission. The judgment of the Commission on these matters b. No claim for pecuniary award or compensation under the provisions of the Atomic Energy Acts of 1946 and 1954 s h a l l be asserted Iy the Contractor or its employees with respect t o any invention or discovery made or conceived inthe course of, i n ,connection with, or under the terms of this contract. C. Except as otherwise authorized i n writing by the Commission, the Contractor will obtain patent agreements t o effectuate the purposes of paragraphs a. and b. of this article from all persons &o perform any part of the work under this contract, except such clerical and manual labor personnel a s dll not have access t o technical data. d. Except as otherwise authorized i n writing by the Commission, t h e Contractor will insert in all subcontracts provisions making this article applicable t o the subcontractor adits employees. The Contractor shall have full freedom of publication of the results of the research under this contract and the Contractor is urged t o disseminate the results of the work through custcinary scientific publication channe1'8, except that "restricted data" as defined i n the Atomic Energy Act of 1954 s h a l l be governed by the provisions of Paragraph 3 of this Appendix "Bn. publications shall include a reference that the results were developed under a Commission sponsored project.

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a. It is understood that the work under this contract will not involve restricted data or other classified matter and that the Contractor will perform such work as unclassified work. However, i f in the course of such work any discoveries a r e made or any data used or developed that constitute restricted data o r other classified matter, the Contractor shall pmmptiy inform the Commission and will be bound by t h e following: ContPactorDsDuty to Safeguard Restricted Data and Other this contpact the Contractor shall, i n accordance with the Commfssfon~s security regulations and requirements, be rssponsfble for safeguarding restricted data and other classified matter arid protecting agefnst sabotage, espionage, loss ard theft,the classified docments, materials, equipnent, processes, etc,, as well as such other material of high intrinsic or strategic value as may be i n the Contractor's possession i n connectSon with performance of work under t h i s contract. Except as otherwise expressly provided in the specifications the Contractor shall upon caplet ion or termination of this contract transmit tothe Commission any classified matter i n the possession of t h e Contractor or any person under the Contractor's control i n connection with performance of this contract. Inthe performance of the work under Remilations. The Contractor agrees t o conform toall security regulations and requirements of t h e Commission. Definition of Restricted Data. The term "Restricted Data", as used in this &rticle, …