Supplemental Agreement - Contract No. at-(40-1)-1975, Medical College of Georgia, Modification No. 3

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Medical College of Georgia THIS SUPPLEMENTAL AGREEMENT, entered into this J&& day o f -, 1957, by and between t h e UNITED STATES OF AMERICA (hereinafter called the "Government"f), represented herein by t h e UNITH) STATES ATOMIC ENWOY CCBQlISSION (hereinafter called the ttComission"), and UD ICAL COLLEE OF GEORGIA (hereinafter called the tlContractOr"); WHEREAS, the Government and the Contractor entered i n t o Contract No. AT-(h0-1)-1975, dated February 11, 1955, providing f o r performance of an investigation of the results of treating crippling emphysema with Iodinecompletion of the research described i n TITLEnI of Appendix I'A", without additional funds t o obtain reports thereon, and to effect certain other changes as are hereinafter more particularly described; and WHEREAS, the contract has been amended heretofore by YodFfications WHEREAS, the Commission desires to provide for additional time for WHEREAS, t h i s Supplemental Agreement is authorized by and executed under the Atomic Energy Act of 19%; NOW, THEREFORE, the parties hereto do mutually agree that said contract is hereby modified inthe following particulars, but i n no'others: 1. me following new Section "5." i s added t o Article It "5. The Contractor s h a l l commence the work as soon as feasible,' prosecute it kif21 due diligence and submit the reports required hereunder a s early as practicable, and not later than the dates 2. The heading of Article If is changed from VERM OF CONTRACT" t o nSCHEDULEN,and the f oll ming new Section nL," is added t o Article3 llL. The 'period during which the work under t h i s contract may be conducted i s hereby extended t o December 31, 7.958.S 3. In subsection 1. c. of Article III, delete t h e words "for the third period of performance".

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L. Subsection 2. a. of Article I11 i s revised t o read as follows: "a. On o r before the date of coamencement of the work on the project described i n Appendix ! A ' ,the Government shall pay t o t h e Contractor upon submission by the Contractor of a properly certified voucher, h5per cent of the agreed consideration; provided, however, that this payment shall be reduced by the amount of the balance, i f aqy, agreed t o be remaining unexpended from the previous work under this contract.1t 5. I n subsection 2. C . of Article 111, delete the word I * term fl and substitute theref o r the word hvorktt. 6, Section 3 . of Article I11 i s revised t o read as follows: When renewal ofthe contract i s desired, the Contractor shall submit t o the Commission's Oak Ridge Operations Office a renewal proposal as outlined i n Appendix I C ' attached hereto. The Contractor and the Commission shall then negotiate as tothe amounts each will conkribute for the additional research activities t o be conducted, taking into consideration the actual costs incurred for the current work i n comparison with the cost estimates inthe contract, and, upon agreement, shall execute a formal modification of the contract." 7. I n TITLE I11 of Appendix nA", delete the dates "January 1, 1957 - 8. I n the introductory paragraph of TITLE I11 of Appendix ftAll, delete the words "for the third period of performancett. 9. I n subsection 2. a. of TITLE I11 of Appendix "A1', delete t h e 11. Paragraph 2. Publications of Appendix IIBfI is revised t o read as "It i s intended that the Contractor shall have full freedom of publication of the results of the research under this contract

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and the Contractor is urged t o disseminate the results of the work through customary scientific publications channels, except that ' restricted data' a s defined i n the Atomic Energy Act of 19Sb shall be governed by the provisions of Paragraph 3 . of this llHowever, i n order to in sure that the public disclosure of such results will not adversely affect the patent interests of the Government provided i n Paragraph 1. of this Appendix IB1 entitled (Patents' approval for such release ghall be secured from the Comission prior to any such publication. ! ' All publications shall include a reference that the results were developed under a Commission sponsored project. 12. Appendix IT1 ' i s deleted i n its entirety and the new Appendix WCn attached hereto and made apart hereof is substituted therefor. I N WITNESS WHEREOF, the parties have executed this Supplemental Agreement the day and year first above written. UNITED STATES OF A I ERICA ACCEPTANCE BY SENIOR INVESTIGATOR BY: UNITED STATES ATQMIC ENERGY CWSSION Research afld Development DFV~ZI~D read t h e foregoing Supplemental Agreement and the Appendix and made a part hereof and agree t o be bound by t h e provisions of

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REPORTS AND PROPOSALS (FOR DIRECT AEX RESEARCH CONTRACTS) 200-word summary of purpose and scope with submittal date indicated there on Complete Scientific Report Brief reports or manuscripts may be submitted as desired by Within 30 days after J II wu r1 Three On contract expiration or With renewal proposal i f proposal is submitted, otherwise on contract expiration or All of the above should be addressed to: Research and Development Division Oak Ridge Operations Office Post Office Box E Oak Ridge, Tennessee The progress =port should briefly describe the scope of investigations undertaken and the significant msu lts. obtained. It should also explain any Significant dif - ferences between the actual level of activity (expressed i n the various categories of man-mths, facilities procured, travel per fo md, etc.) and that contemplated i n the contract. Technical meports and articles prepared for publication should be listed with bibliographic references. & prints or pre prints of all such material should be appended and material contained there in need not be duplicated i n the Renewal proposals, if any, should accompaw the progress r e p o r t and should contain the type of information outlined below unless t h e information i s already contained in earlier proposals or i n the accanpaqdng progress report. change i n program or scope for the additionalmrk should be clearly explained and the cost estimated should be based upon past experience.

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1. Title of the project, 3.Scientific background including literature relevant t o the proposal, the The institution and department i n which the work will be done. significance, and the motivation. work already i n progress the extent of pl.esent support should be stated identifying amounts received from federal agencies. If the proposal isfor continuation of 4. Scientific scope of the proposed research, its objectives, its relation to present knowledge and t o comparable work i n progress elsewhere, and a plan of accomplishments f o r the work. Scientific Personnel, Give the name, highest academic degree, position i n the institution,scientific experience, publications and accomplishments of the Senior Investigator (the individual who will actively direct the research program) and of each regular staff scientist who it i s proposed will engage devoted t o the project. Scientific personnel t o be mwly employed for the project should be so designated, and professional records given if possible. Indicate the approximate fraction of the time of each t o be 6 . Other Personnel. The number of persons of each sub-professional grade dnd the fraction of the time of each t o be devoted t o the project should be listed, Graduate student employees should be identified as such if their thesis is t o be related to the project. 7. Other Financial Assistance. If assistance for this or other activities h vol ving the same personnel or facilities is to be proposed to, o r received from other federal or non-university sources the extent of that assistance should be clearly stated, and the interplay of the arrangements should be 8, Materials, Equipmnt and Fac il ties. List those already available for the work and justify the need for major items t o be procured. 9, Travel and Other Items. Explain the purpose of the proposed travel, and of any other major items in the budget. funds for attendance a t regular scientific meetings should conform with the policy of the institution in the use of its own funds for these purposes. Travel rates and the use of contract the progect, It should include: alist of the i divi dual salaries at - tri but able to the project, supplies and services, equipment (defined as things individually costing more than $500 shich will retain their utility f o r more than a year), travel, communication and publication, and the indirect costs allocable t o the project. The basis for computing the indirect costs should be briefly explaimd. The budget should not include the stipend of felloW8. i n accord with the established policies of the institution, or, i f not, an explanation should be submitted. This should list in detail all items of cost necessary to carry All salaries chargeable tothe project should be

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Amount Requested. A statenrent of the part of the total amount listed the budget which the institution is prepared t o bear, and the amounts requested from the AEC. and a statement of any other sponsors of the project with the amounts contributed by each.- The proposal should be signed by the Senior Investigator and endorsed by a responsible administrative officer of the institution. Statement of Current Expenditures. A current statement of its expenditures f o r the project, and an-estimate of expenses t o be incurred. Residual Funds. Any difference in the scope of the work from that contemplated i n the contract, a s brought out i n the report, may be reflected in the amount funds,, A proposal for such renewal should state the scope of the work proposed for use of residual funds. If no new funds are required the contract may be renewed without radioisotopes purchase reports hall list all radioisotopes included inthe budget a t the &gular price established by the Commission, but which are purchased, or will be purchased under the current budget, ata price less than the established price by utilizing the discount authorized by an AEC Discount Certificate issued t o the Contractor. For each ach purchase, the report shall state the price as establi shed by the Commission, the price paid orto be paid using the discount, and the savings realized or t o be realized. expiration shall cover all such purchases actually made and not previously reported. The report due on contract termination o r

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YBdical College of Osorgia THIS SUF'PLEMENTAL AQRBEMENT, entered into this 1957, by and between the UNITED STATES OF AY WI CA Wovermentw), represented herein by the UNITED STATES ATOMIC ENERGY CUMMISSION after called the *Contractor*): WHERIW, the Government and the Contractor entered i n t o Contraat lo. AT- (h0-1)-1975, dated February 11, 1955, providing for performance of an investigetfon of the results of treating crippling emphysema with Iodine-131; and WHEREAS, the Contract has been amended heretofore by Modification No. A ; UHERIW, t h e parties hereto desire t o extend the term of the contract in order t o continue the research activities previously undertaken, a8 such extended program is described i n TITLE XI of Appendix BAW, and to effect certain other changes a8 are hereinafter more particularly described; and IMEwehS, t h i s Supplelsbntal Agreemaent is authorized by and executad under the Atomic Energy Act of 19%; NOW, THEREFQU, tho parties hereto do mutually agree t h a t said contract is hereby modified i n the f oll ming particulars, but i n no others: 1. The following new section "3." is added t o Article 11: w3. The t h i r d period of performance for the research vooject covei? t h i s contract rill commence on January 1, 1957, and rill end on December ji, 2. The following new subsection w l . c.. is added i n Article 111: *c. I n consideration of the performance of the research activities described in TT RZ III of Appendix "Am, and the Contractor's agreementl t o support t h a t work i n the estimated amount of Five Thousand, Five Hundred Three and 5O/lOO Dollars ($s9s03.S0), the Government will pay t o the Contractor for the third period of performance the sua of Two Thousand, Eight Hundred Fifty-seven Dollars 3. Subsection 2. a. of Article I11 is revised to read a s followst

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*a 0 On or before t h e date of commencement of the work on the project mission by the Contractor of a properly certified voucher, 45 per cent of the agreed conaideration; provided, however, that this paynent shall be reduced by the amount of the balance, if a m , agreed t o be remaining unexpended from the previous period of performancee" b e The f ollming' new TITIil3 nIIIa is added i n APPENDIX mAn: This TITLE 111 describes the research program and c o s t estimates agreed upon between the Commission and the Contractor f o r t h e thii.d period of performance. @a. Scope and Plan of Approach: The Contractor will continue work, utilizing Iodim-131 radioactive isotope t o determine if iodine will reduce the oxygen demand in patients so that crippling emphysematous lungs w i l l supply the demand with less distress. lends itself to more intensive study, and-a seriss of 26 patients is being followed I n order t o be sure of t h e effects of the treatment and to differentiate cases that are or are not helped. The encouraging experience with this treatment oa Outline of Coat Estimates f o r the Third Period: (3) Indirect Coats and Servicest 2,185.50 *It is recognized t h a t the research program may be further supported From other sources a s outlined in the Contractor's proposal. wb, Item of property t o be procured or manufactured by the Contractor during this period, title to which will vest i n the Governarsnt (aee Article V):

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IN WITNESS WHEREOF, the parties hereto have executed t h i s Suppleplental UNI’iSD STATES OF AMERICA I have read the foregoing Supplemental Agreement and agree to be bound the provisions of this doaument.

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Medical College of Georgia 1956, effective as of January 1, 1956, by and betweem the UNITED STATES Ow AMERICA (here in after called the nGOvermntlf),represented hercdn by the UNITED MEDICAL COLLEGE OF GECRGIA (here in after called the "Contractor"); WHEREAS, the Gmernment and the Contractor entered into Contract No. AT- (40-1)-1975, dated February 11, 1955, providing for pr fon a ance of an invest i - g ation of the results of treating crippling emphysema with Iodine-131; and WHEREAS, the parties hereto desire t o extend the term of the contract i n order t o continue the research activities previously undertaken, as such extended program is described i n TITLE …