Lump Sum Research Contract - Contract No. at-(40-1)-2685

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ATOMIC ENERGY COMMISSION c THIS CONTRACT, entered into this l‘th- day of :larch , 1960, by and between the United States of America (here in after called the ltGovernmentll), acting through the UNITED STATES ATOMIC ENERGY COMMISSION (hereinafter called then Cods sion tl) and EMORY UNIVERSITY (here in after WHEREAS, the Commission, i n furtherance of its policy of assisting and fostering private research, desires to support the Contractor’s fundamental research in the field of atomic energy; and WHEREAS, this contract is authorized by and executed under the Atomic Energy Act of 1954; NOW, THEREFORE, the parties hereto do mutually agree as follows: 1. The work shall consist of research by the Contractor involving the study of sulfomucopo1ysacchaxd.de metabolism inpatients with hepatocellular injury with S-35 labeled sulfate. the agreed upon program and budget for the project are described i n Appendix VIA”, which is hereby made a part of this contract. The Contractor shall be guided by, but not bound t o conform t o the details of, the budget described The plan of ay roach to the problem and 2. The Contractor shall furnish all services,facilities, equipment, supplies and materials (except such services, equipment, supp lle s and mate rials as the Government has agreed to furnish here in) required for the performance of the research program described in Section 1. above. 3* The work will be carried out by the Contractor under the direction of Dr. John T o Galambos as Senior Investigator. &. The Contractor s h a l l commence the work as soon as feasible, prosecute it with due diligence and submit the reports required hereunder as early as practicable and not later than the dates specified in Appendix llC1t. 1. The period during which the work under the contract may be conducted shall end on January 31p 1961.

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a. I n consideration of the performance of the research activities described in T IT IEI of Appendix llA1l, and the Contractor ts agreement t o support that work inthe estimated amount of Thirty-eight Thousand, Two Hundred Forty Dollars ($38,2L0.00), the Government shall pay t o the Contractor Fifteen Thousand Dollars ($1~,000.00). a. On o r before the date of commencement of work on the project described i n Appendix 'IAN, the Government shall pay tothe Contractor, upon submission by t h e Contractor of a proper voucher, &s per cent of t h e agreed b. On o r before the expiration of six months from the date of' commencement of the project, the Government shall pay tothe Contractor, upon submission by t h e Contractor of a proper voucher, Ls per cent of t h e c.. Upon receipt and acceptance of a satisfactory progress reDort, i n cases where the contract is t o be renewed, or the final report if the contract is not t o be renewed, the Government shall pay t o the Contractor, upon submission by the Contractor of am oper voucher, the remaining 10 per cent of the agreed consideration. without additional funds shall not be considered a renewal of the contract and i n such cases the retained 10 per cent of the agreed consideration will be paid upon submission and acceptance of a satisfactory final report. An extension of the contract work de I n the event the contract is renened, payments tothe Contractor cf any additional amount t o be paid by the Government shall be made for the extended work i n accordance with the schedule outlined i n paragraphs a., b., When renewal of the contract is desired, the Contractor shall submit to the Cods sion ts Oak Ridge Operations Office a renewal proposal as outlined i n ApDendix "C" attached hereto. shall then negotiate as tothe amounts each will contribute for the additional research activities to be conducted, taking into consideration the actual costs incurred for the current work i n comparison nith the cost estimates i n the contract, and, upon agreement, shall execute aform1 modification of the The Contractor and t h e Commission

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ARTICLE IV - REPORTS. REUIIDS AND INSPECTION 1. m e Commission shall have the right to Fnspect in tch nanner and a t such times asit deems appropriate all activities of the Contractor arising in the course of the work under this contract. 2. The Commission shall atall times be affarded access t o the premises and to all technical records, correspondence, instruct ims, drawings and memoranda of record value o f the Contractor pertaining t o 3.me Contractor shall make progress and other reports in such manner and a t such times as specified in Appendix llCfl which is attached and hereby made apart of this contract. 4. Examination of Records a. The Contractor agrees t h a t the Comptroller Qeneral of the United States or aqy of his duly authorized representatives shall, until the expiration o f three years after final payment under this contract, h m access to and the right to examine any directly pertinent books, documents, papers and records ofthe Contractor involving transactions related to this b. The Contractor further agrees t o include in all his subcontracts hereunder a provision to the effect that the subcontractor agrees that the Comptroller General of the United States or any of his duly authorized representatives shall, until the expiration of three years after flnal payment under the subcontract, have access t o and the right to examine any directly pertinent books, documents, papers, and records of such subcontractor, involving transactions related to the subcontract. nsubcontract" a s used i n this clause excludes (1)purchase orders not exceeding $2500; (2) subcontracts o r purchase orders for public utility sen - ices at rates established for uniform applicability to the general public; and (3) subcontracts o r purchase orders f o r general inventory items not apec if ic ally identifiable with the work under this contract. C. Nothing in this contract shall be deemed t o preclude an audit by the General Accounting Office of any transact im under this con-

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I n considera tion of the Contractor s contribution t o the research project described i n Appendix "A*' of this contract, title to all materials, tools, machinery, equipment and supplies a cqd red from any source, including the Government, o r manufactured by the Contractor under this contract, shall vest inthe Contractor, except that title to items of property describe d in section 2. b. of Appendix f*A" shall vest or remain i n the Government. Additional items may be added t o such sec tim 2. b. in writing without the necessity for a fqrmal modi fic a tim of the contract. F'ACILITIES;cowLIANCE WITH COMMISSION REGULATICNS The mn tractors hall comply with all licensing and other requirements of the Commission with respect to possession and use of by-product material, source material, and special nuclear material (as these terms are defined in t h e Atomic Energy Act of 19%), and may purchase o r acquire such materials,irradiation services, other radioactive material, cyclotron time, etc., fr m the Commission o r Commission facilities in accordance with apARTICLE VI1 - PURCHASE OF RADIOISOTOPES UNDER AN AEC DISCOUNT If any radioisotopes are budgeted in the outline of cost estimates atthe full amount of the price as established by the ~ m mission ,b u t are purchased a t less than such established prices under a n AEC Discount Certif i cate issued t o the Contractor (See: any difference between the established price ad the -price s o paid shall be paid by the Contractor tothe Government o r otherwise credited to the Governmentts account as the Contracting Officer may direct o r approve. requirement for a report to be submitted t o the Commissian indica bg the purchases under the discount program i s outlined i n Appendix nCw. h e provisions of Appendix fBf7, attached hereto, are hereby made a part of this contract. The following alterations to this contract were made by mutual agreement ofthe parties prior to its execution: None.

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I N WITNESS WHEREOF, the parties here to have executed this contract the day a d year first above written. UNITED STATES OF AMERICA RESEARCH AND OLY ACCEPTANCE BY SENIOR INVESTIGATOR I have read the foregoing contract and t h e Appendices attached hereto and made a part hereof and agree t o be bound by the provisions of thls

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This TITLE I describes the research program and cost estimates agreed upon betmeen the Commission and the Contractor. a. Scope and Plan of Approach: The Contractor will conduct studies of sulf omucopolysaccharide metabolism i n selected patients with hepatocellular injw, utilizing S-35 labeled sulfate as appropriate. include studies of patients with acute hepatitis,fibrosis, cirrhosis, primary and secondary cancer of the liver, and will be compared with controls having normal liver and liver funcincluded. Patients treated with 100 microcuries of S-35 sulfate will be evaluated with respect t o body fluids rates of disappearance of labeled sulfate from serum an3 t h e body, and on basis of data, the l'compa.rtmentsll of the body where sulfate i s entering and their relations will be defined. Special attention will b e paid t o the slcnvly exchanging sulfomucopolysaccharide comparttissue, including his to logical examination. as well as biopsy samples will be examined appropriately with regard t o chemical analysis, total sulfur and sulfate, specific activities of S-35, with appropriate his to logical examination. Serum mucoprotein will be measured in each S-35 study b y electrophoresis and chemical analysis. The work will Laboratory evaluation, tissue studies, etc., will be Autoradiographic and chemical studies will be made on Surgery and autopsy a. Outline of Cost Estimates: (1) w rie sad Wages: $2 3,366 00 Chemists and Tissue

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(4) Indirect Costs (27%of direct charges): 11,3190010 b. Items o f property to be procured o r manufactured by the Contractor, o r to be furnished by the hvernment, tit&! to which will vest o r remain in the Government (see Article V)r None

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Whenevor any invention o r dlscovery is made or conceived by the Contractor or itr anployees inthe course of, i n connection wlth, o r under the terms of thlr contract, the Contractor s h a l l furnish the Commlsdon wlth complete information thereon; and the Cads sion shall have the mle power t o determine whether o r not and where a patent application shall be filed, and to dotormine the disposition of the title to and rights under q application or patent thatm4redt. ?he judgment of the cornmission on there nut tor8 ahdl be accepted as final ; and the Contractor, for itself and for its emph yoe s, agrees that the inventor o r inventors dl1 execute dl documents and do ell things necessary or proper t o carry out the judgment of the No c lda for pecuniary award or compensation under the pr ovid on r of the Atomic &or= Acts of 19b6 and 19% shall be asserted by the contractor or Its 0apby0e8 wlth respect to any invention or discovery made o r concdved i n the course of, I n connection ulth,or under the terms of this contract. Except as o the dm authorized In writing by the Conrmisdon, the Contractor nill obtdn patent &greements to effectuate the purpomr of pmagraphr a. and b. of this article f'rom all persons who perform any part of the work under this contract, except such clerical and manual. l a b o r personnel as wlll not have access to technical data. kcept as otherwise authorized in writing by the Commission, the Contractor dl Insert in all subcontracts provisions making this article applicable tothe rmbcontractor and its employees. It is intended that the Contractor shall have full freedom of publication of the r ellul tr of the reeearch wider this contract and the Contractor i a urged to disreminate the results of tho work through customary scientific publication ch.nnd.a, except that " restricted data" as defined in the Atomic Energy Act of 19% shall be governed by the provisions of Paragraph 3. of this Appendix "Bn. However, in order t o insure that the public disclosure of such results NIUn o t &erse&y affect the patent inter eats of the Government provided i n Paragraph 1. of this Appendix "Ba entitled "Patentell, approval for such release shall be ~ectlredfrom the Conmimlon prior to any such publication. All publications ohall include a reference that the results were developed der a Commiudon aponaored project.

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a. It I s understood that the work under this contract will not involvo rer t ric ted data or other classified matter and that the Contractor rill perform such work as unclassified work. However, I f in the course of such work any discoveries a r e made o r any data used or developed that constitute restricted data o r other classified matter, the Contractor shall promptly inform the Commission and will be bound Contractor's Duty t o Safemard Restricted Data and Other this contract the Contractor shall, i n accordance with the Comrnirdon's security regulations and requirements, be reaponsible for safeguarding restricted data and other class if led matter end protecting against sabotage, espionage, loes and theft, t h e classified documents, materials, equipment, proces808, atc., as well as such other material of high in tr in dc or strategic value as may be in t h e Contractor's possesdon in connection w l t h performance of work under this contract. lb cept as othsrrrlse expressly prodded h the apacificationr tho Contractor shall upon completion o r termination of this cantract transrnit t o the carnmission any classified matter i n the possession of the Contractor or any person under the Contractor'r control in connection with performance of this contract. In t h e performance of the work under at ions and requlraments of the Commission. The Contractor agrees t o conform toall security used In this article, means all data concernin (1) design, manui act ure,or ut t liz ation of atomic weapons; (zf the proctuction of special nuclear material; or (3) the use of special nuclear materiel in the production of energy, but shall not include data declassified or removed from the Restricted Data category puraant to section 142 of the Atomic Energy Act of 19%. Security Clearance of Personnel. authorize, in accordance with the Atomic Energy &t of 1951, the Contractor shall not permit any individual t o have access to Restricted Data until the designated investigating agency shall have made an investigation and report to the Commission on the character, associations, and loyalty of such indivldual and the Commission shall have determined that permitting slch person t o have access to Restricted Data will not endanger the common defense and security. &cept a s the Commission may As used i n this paragraph, the

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term lldesignated investigating agency" meam the Uhited State6 civil Service Commission orthe Federal Bureau of Investigation, o r both, as determined pursuant …