Supplemental Agreement - Contract No. at-(40-1)-1829, University of Tennessee, Modification No. 1

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University of Tennessee THIS SUPPLEMENTAL AGREEMEN", entered into this 1958, effective as of June 1, 1958, by and between STATES ATOMIC ENERGY COMMISSION (here in after called the Vommission"), and the UNIVERSITY OF TENNESSEE (here in after called the "Contractor") ; WHEREAS, the Government and the Contractor entered into Contract No. AT- (40-1)-1829, dated June 6, 1957, providing f o r research into t h e metabolism of alkaline earth metals by bone; and WHEREAS, the Commission desires to provide for additional research a s more particularly described i n TITLE I1 of Appendix "An, t o obtain reports thereon, and to effect certain other changes a s are here in after more particularly WHEREAS, t h i s Supplemental Agreement is authorized by and executed under t h e Atomic Energy Act of 1954; NOW, mEREFaRE, the parties here to do mutually agree that said contract is hereby modified i n the following particulars, but i n no otherat 1. The following new section "5." is added to Article 11 ' 5 . The Contractor shall commence the work a s soon as feasible, prosecute it with due diligence and submit the reports kequired hereunder a s early a s practicable, and not later than the dates specified i n Appendix W".' 2. The heading of Article I1 is changed from "TERYI OF CONTRACT" t o "SCHEDULEn and the following new section N2.n i s added to Article118 "2. The period during which t h e work under t h i s contract may be conducted i s hereby extended t o May 31, 1959.n 3. The f oll ming new subsection "1. b.' is added in Article 111: "b. In consideration of the performance of the additional work described i n TITLE I1 of Appendix "An, and the Contractor's agreement t o support that work i n t h e estimated amount of Seven Thousand, Seven Hundred Fifty-six Dollars ($7,?56.00), the Government will pay t o the Contractor Eight Thousand, Five Hundred Eighty Dollars ($8,580.00).

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4. I n subsection 2. c. of Article 111, delete the word "term" and subst it ute there for the word bork " . 5. Section 3. of Article I11 is revised to read a s follmst "When renewal of the contract is desired, the Contractor shall submit t o the Commission's Oak Ridge Operations Office a renewal proposal a s outlined in Appendix H C N attached hereto. The Contractor and the Commission shall then negotiate as to the amounts each will contribute for the addit ional research activities to be conducted, taking into consideration the actual costs incurred for the current work i n comparison with the coste sti - mates inthe contract, and, upon agreement, shall execute a formal modification 6 . The fallowing new TITLE VIn i s added in Appendix WThis TITLE I1 describes the research program and cost estimates agreed upon between the Commission and the Contractor. Ma. Scope and Plan of Approach: The Contractor will continue studies on and related to the metabolism of alkaline earth metals by bone, particularly with regard t o strontium and calcium, utilizing radioactive isotopes such as The program w ill include ( a ) t h e uptake of strontium by human bone utilizing bone cultures, (b) the effect of species upon strontium uptake i n chick and human bone and in relation to the Sr/Ca ratio, (c) the effect of development and the degree of calcification upon the discrimination for strontium a s compared with calcium, (d) contin u ation of the studies of the alkaline earth elements with regard t o uptake and removal by bone, ( e ) the function of enzymes i n the control of discrimination as affected by inhibitors,available strontium and calcium, etc.,(f)action of the harmones, and (g) the action of temperature on the Sr/Ca ratio in bone. pri ate experiments to elucidate the metabolism of the important alkaline earth elements i n bone will be conducted a s needed.

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"a. Outline of Cost Estimates: Salaries and Wages: Administrative and Secretarial Publication and Communication: Overhead and Indirect Costs: *It is recognized that the project may receive additional financial support a s described inthe Contractor's proposal t o the Comission. ''be Items of property t o be procured or manufactured by t h e Contractor, title to which will vest in the Government (see Article V): N0ne.N 7. Paragraph 2. Publications o f Appendix NBW is revised t o read a s follows: "It is intended that the Contractor shall have full freedom of publication of t h e results of the research under t h i s contract and the Contractor is urged t o disseminate the results of the work through customary scientific publication channels, except that ' restricted data ' a s defined ir. the Atomic Energy Act of 1954 shall be governed by the provisions of Paragraph 3. of this Appendix HHowever, i n order t o insure that the public disclosure of such results will not ad wr s ely affect the patent interests of the Government provided i n Paragraph 1. of this Appendix NB N entitled IPatentsI approval for such release shall be secured from the Commission prior to any such publication. NAll publications shall include a reference that the results were developed under a Commission sponsored project."

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I N WITNESS WHEREOF, the parties hereto have executed this Supplemental Appendix nCn i s deleted in its entirety, and the new Appendix Wn attached hereto and made apart hereof is substituted therefor. Agreement the day and year first above written. UNITED STATES OF AMERICA ACCEPTANCE BY SENIOR INVESTIGATOR I have read the foregoing Supplemental Agreement and the Appendix Wn attached hereto and made apart hereof and agree t o be bound by the provisions of this document.

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REPQRTS AND PROPOSAIS (FOR DIRECT AEC RESEARCH CONTRACTS) 200-ward summary of pose and scope with submittal date Complete Scientific Report Brief reports or manuscripts may be submitted as desired by Sen i or Investigator On contract expkration o r proposal is submitted, otherwise on contrast expiration or t e rmina ti or; All of the above should be addressed tor Research and Developmen5 Division Oak Ridge Operations Office Post Office Box E Oak Ridge, Tennessee The progress report should briefly describe the scope of investigations undertaken and the significant results obtained. It shoaid aiso explain aqy significant differences between the actual level of activity (expressed inthe various categories of man-months, facilities procured, travel performed, etc,) and that contemplated in the contract. Technical reports and articles prepared for publication should be listed with bibliographic references, Reprints or pre prints of all such material should be appended and materiai contained thereir, need not be duplicated i n the Renewal proposals, i f any, should accompany the prcjgress report and should contain the type of information outlined below ur-less she iriormation i s already contained i n earlier proposals or inthe azcompanying progress report, change i n program or scope for the additional work should be clearly explained and the cost estimated should be based irpon past experience.

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1. Title of the project. The institution and department i n which the work will be done. Scientific background including literature relevant tothe proposal, the significance,andtk motivation. If the proposal is for continuation of work already in progress the extent of present support should be stated identifying amounts received from federal agencies. 4. Scientific scope of the proposed research, its objectives, its relation to present knowledge and t o comparable work in progress elsewhere, and a plan of accomplishments f o r the work. the institution,scientific experience, publications and accomplishments of the Senior Investigator (the individual who will actively direct the research program) and of each regular staff scientist who it is proposed will engage devoted t o the project. project should be s o designated, and professional records given if possible. Give the name, highest academic degree, position in Indicate the appmximate fraction of the time of each t o be Scientific personnel t o be newly employed for the 6. Other Personnel. The number of persons of each sub professional grade and the fraction of the time of each t o be devoted to the project should be thesis is t o be related to the project. Graduate student employees should be identified as such if their 7. Other Financial Assistance. If assistance for this or other activities involving the same personnel or facilities is t o be proposed to, o r received from other federal or non-university sources the extent of that assistance should be clearly stated, and the interplay of the arrangements should be 8. Materials, Equipment and Facilities .- work and justify the need for major items t o be procured. List those already available for the 9. Travel and Other Items. Explain the purpose of the proposed t r a v e l , and of any other major items i n the budget. funds for attendance at regular scientific meetings should conform with the policy of the institution in the use of its own funds for these purposes. Travel rates and the use of contract the project. It should include: a list of the individual salaries attri but able to the project,supplies and services, equipment (defined as things individually costing more than $500 which will retain their utility for more than a year), travel, communic?tion and publication, and the indirect costs all o cable to the project. The basis for computing the indirect costs shoald be briefly explained. The budget should not include the stipend of fellows. i n accord with the established policies of the institution, or, if not, an explanation should be submitted. This should list in detail all items of cost necessary to carry All salaries chargeable t o the project should be

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budget which the in sti bits fon is prepared t o bear, and the amounts requested A statement of the part of the total amount listed in the from the AEC, and a statement of any other sponsors of the project with the amounts contributed by each. The proposal should be signed by t h e Senior Investigator and endorsed by a responsible administrative officer of the insti - Statement of Current Expenditures. for the project, and an estimate of exp n sesto be incurred. A current statement of its expenditures Residual Funds. Any difference in the scope of the work from that contemplated i n the contract,as brought out i n the report, may be reflected in the amount for use of residual funds. If no new funds a r e required t h e contract may be renewed without A proposal for such renewal should state the scope of the work proposed radioisotopes purchase reports hall list all radioisotopes included inthe budget atthe regular price established by the Commission, but which are purchased, or will be purchased under the current budget, at a price less than the established price by utilizing the discount authorized by an AEZ Discount Certificate issued t o the Contractor. For each such purchase, the reports hall state the price as established by the Commission, the price paid orto be paid using the discount, and the savings realized or to be realized, cover all such purchases actually made and not previously reported. The report due on contract termination or expiration shall

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between the UNITeD STATES OF U EZ ICA(here in after a all ed the nCovernmentn), acting through the UNITED STATES ATOMIC ENERGY COWISSION (hereinafter called 1. The Commission, i n furtherance of its policy of assisting and foster - ing private research, desires to support the Contractor's fundamental research i n the field of atomic energy. 2. Ths work shall consist of research by the Contractor into the metabolism of alkaline earth metals by bone. the agreed upon program and budget for the project are described i n Appendix PAW9 which i s hereby made apart of this contract. guided by, but not bound t o conform to the details of,the budget described i n The plan of approach tothe problem and The Contractor shall be 3. The Contractor shall furnish all services, facilities, equipment, supplies and materials (except such service8, equipment, supplies and materials a s the Government has agreed t o furnish herein) re qu bed for the performance of the resaarch program described i n Section 2. above. b. The work will be carried out by the Contractor under the direction of Dr. Frederick W e Lengemann a s Senior Investigator. 1. The initial period of performance for the research project covered by this contra& will commence on June 1, 1957, and w i l l end on May 31, 1958. It 5.3 recognized that completion of the research work under this contract may involve 8 period of several years and that the term of this contract may be extended by mtnel agreement. a. I n consideration of the per f om ce of the research activities described in Title I of Appendix RAW9 and th Contractor's agreement t o support

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that work inthe estimated amount of Seven Thousand, Five Hundred Ninety-six Dollars ($7,596.00)~t h e Government will pay tothe Contractor for the first period of performance t h e sum of Eight Thousand, Six Hundred Forty Dollars a. On o r before the date of commencement of work on t h e project described i n Appendix HAR, the Government shall pay t o the Contractor upon submission by the Contractor of a properly certified voucher, 45 per cent of b e On OT before t h e expiration of six months from the date of commencement of the project, the Government shall pay t o the Contractor, upofi submission by the Contractor of a properly certified voucher, 45 per cent of c o Upon receipt and acceptance of a satisfactory progress report, i n eases where the contract is t o be renewed,, or the final report if the contract is not t o be renewed, the Government shall pay t o the Contractor, upon submission by the Contractor of a properly certified voucher, the remaining 10 per cent of the agreed consideration. An extension of the contract term without additional funds shall not be considered a renewal of the contract and i n such Cases the retained 10 per cent of the agreed eonsideration will be paid upon submission and acceptance of a satisfactory final report. d. I n the event t h e contract is renewed, payments to the Contractor of ary adaftional amount t o be paid by the Government shall be made for the extended term in accordance w i t h the schedule outlined i n Paragraphs a., b., 3 . -am end Budget for Subsequent Periods When renewal of the contract is desired, the Contractor shall submit to t%e Commission's Oak Ridge Operations Office a renewal proposal as outshall then negotiate as tothe amounts each will contribute for these recea t o be performed during the …