Lump Sum Research Contract - Contract No. at-(40-1)-1823

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Contr act No acting through the UNITED STATES ATOMIC ENERGY COMMISSION (hereinafter ca lied ARTICLE I - PURPOSE AND SCOPE 1. The Comnission, i n furtherance of its policy of assisting and foster - ing private research, desires to support the Contractor's fundauental research i n the field of atomic energy. 2. The work shall consist of research by the Contractor involving the biology of brain tumors. The plan of approach t o the problem and the agreed upon program and budget for the project are described i n Appendix "A", which i s hereby made apart of this contract. but not bound t o conform t0 the details of, the budget described in Appendix The Contractor shall be guided by, 3. The Contractor shall furnish all services, facilities, eauipment, supp l i e s and materials (except such services, equipment, supplies and materials as the Government has agreed t o furnish herein) reauired f o r the performance 01 the research program described i n Section 2. above. h. The work will be carried out by the Contractor under the direction of Dr. Barnes Woodhall a s Senior Investigator. ART ICU I1 - TERM OF CONTRACT 1, The initial period of performance for the research project covered b y this contract will commence on April 1, 1957, and will end on March 31, 1958. It is recognized that completion of the research work under this contract may invclve a period of several years and that the term of this contract may be extended by mutual agreement. a. f n consideration of the performance of the research activities described i n TIT= l of Appendix wAw, and the Contractor's agreement t o support

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t h a t work i n the estimated amount of Nine Thousand, Eighty-two and 8S/lOO Ibilars ( $ 9,082.85) ~ the Government will pay to the Contractor for the fe3t period of performance the sum of Nine Thousand, Fifty-three Dollars a. On or before the date of commencement of work on the project described i n Appendix RAW, the Government shall pay t o the Contractor upon submission by the Contractor of a properly certified voucher, b 5 per cent of t h e agreed consideration. b. On or before the expiration of six months from t h e date of commencement of the project, the Oovernment shall pay t o the Contractor, upon submission by the Contractor of a properly certified voucher, 45 per cent of c. Upon receipt and acceptance of a satisfactory progress report, ip1 cases where the contract is t o be renewed, or the final report Ff the contract is not t o be renewed, the Government shall pay tothe Contractor, upon submission by the Contractor of a properly certified voucher, the remaining 10 per cent of the agreed consideration. An extension of the contract term without additional funds shall not be considered a renewal of the contract and i n such cases the retained 10 per cent of the agreed consideratim will be paid upon submission and acceptance of a satisfactory final d, I n the event the contract is renewed, payments t o the Contractor of any additional amount t o be paid by the Government shall be made for the extended term i n accordance with t h e schedule outlined I!+IParagraphs a., b., 3. Program and Budget f o r Subsequent Periods Wnen renewal of the contract is desired, the Contractor shall sublnit t:, the Commission's Oak Ridge Operations Office a renewal proposal a s outlined in Appendix WCm, attached hereto. tnen negotiate as tothe amounts each will contribute for the services t o DU performed during the ensuing period, taMng i n t o consideration the actual costs incurred during the current period i n comparison with t h e cost estimates i n the contract, and, upon agreement, shall execute a formal modification of the contract. The Contractor and the Cods sion shall

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ARTICLE IV - REPORTS, REODRDS AND INSPECTION 1. The Cowission shall have the right to inspect i n such mmner and a t such tims as it deems appropriate all activities of the Contractor arising inthe course ofthe work under this contract, 2. The Commission shall at all times be afforded access t o the praises and to all technical records, correspondence, instructions, drawings and memoranda of record value of the Contractor pr tai ning to 3. The Contractor shall make progress and other reports in such manner and at su& thes as specified in Appendix I'C" which is attached and hereby made a part of this car tract. 4. Examination of Recorda a. The Contractor agrees that the Comptroller General of the United States or any of his duly authorized representatives shall have access t o and the right to examine any directly pertinent books, documents, papers and records of t h e Contractor involving transactions related t o this contract until the expiration of three years after final payment under this contract. b. The Contractor further agrees t o include i n all his subcontracts hereunder a provision t o the effect that the subcontractor agrees that the Comptroller General of the United States or any of his duly authorized representatives shall have access t o and the right to examine any directly pertinent books, documents, papers, arvi records of such subcontractor involving transactions related tc the subcontract until the expiration of three years after final payment under t h i s contract. The term "subcontract" as used herein means any purchase order ar agreement t o perfom all or any part of t h e

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work or t o make or furnish any materials required for the performance of this contract, but does not include (1) purchase orders not exmeding $l,OOO, (2) subcontracts or purchase orders for public utility services at rates established for uniform applicability to the general public, or (3) subcontracts or purchase orders f o r general inventory items not specifically identifiable with the work under this contract. c e Nothing in this contract shall be deemed t o preclude an audit by the General Acclcunting Office of any transaction under this contract. In consideration of the Contractor's contribution t o the research project described i n Appendlix "An of this contract, title to all materials, tools, machinery, equip ent and supplies, acquired from any source including the Government, o r manufactured by the contractor under this contract shall vest in the Contractor, except that title to items of popeyty deecribed i n Section 2. b e of Appendix "A" shall vest in the Government. The Contractor shall comply with all licensing ad other requirements& the Cds sion with respect t o possession alld use of byproduct material, source nroterial, and special nuclear rnsterial (as these terms are defined i n the Atomic Energp Act of 1954), ard may prrchase or acqirire such materipla, Irradiation services, other radioactive material,- cyclotron time, etc. from tho Cornmission or Cds sion facilities In accordanbe Hth ARTIQLE VI10 PURCHASE OF RADIOISOTOPES UNDm AN AEC DISC UI HTC SZ TIF I CATE If any radioisotopes are budgeted inthe outline of cost estimates at the full amount of the price a s establfrrhed by the Commissioq, but y e purchased a t less than such established prices under a n AEC Msqount Cqrtifi cate issued t o the Contractor (See: Title 10 C.F.R., Part 37)* then tpy difference between the established price aqd t h e px-ice so paid &dl b$ paid by the Contractor tothe Government or o the dac credited tothe Guvenmnent'8 account as the Contracting Officer may direct or apprwe. for a report to be subrPittsd t o the Ccmmis8i~cnindicating the pur ~ e e swaer t h e discount program i8 outfined in Append- 18C@. The provisions of Appendix "B",attsched hezwtc~,are hereby made a part of this contract. The following alteratiom t o this -were made bJr mat-

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IN WITNESS WHEXtEOF, the parties hereto have executed this contract the day and year first above written. U?lITED STATES OF AMERICA BY: UNID STATES ATOMIC ENERGY \COUISSION ACCEPTANCE BY SENIOR INVESTIGATCR I have read the foregoing contract and t h e Appendices attached hereto and made a part hereof and agree t o be bound by the provisions of this document.

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This TITLE I describes the research program and c o s t estimates agreed upon between the Commission and the Contractor for the first period of performance. a. Scope and Plan of Approach:, The Contractor will undertake studies of brain tumors and brain tumor cases verified as gliblastomae, extending the studies as appropriate t o other classical tumor entities. time i n the various identified types, and a secondary study will be made of changes i n the tumor tissue and the tumor cytology relative to effects fol - lcming roentgen irradiation. will be transferred t o code sheets, together with the neuropathological reports. Sections will be reviewed i n terms of cell type, cell change, and irradiation effect, actual new sections being cut from preserved gross materi al as required. A statistical survey will be made of coded results, and from this together with hand analysis and illustrative neuropathological material, a report will be evolved. Evaluation will be made of tumor cell change i n Accumulated data from individual histories a. Outline of Cost Estimates for the First Period: (1) Salaries and Wages: Dr. Barnes Woodhall (1/3 of time) $1,000 Research Assistants and Labor atory Technician (4) Indirect Costs (38.03% of Salaries and Uages): 3,871.45 b. Items of property t o be procured or manufactured by the Contractor during this period, title to which will vest in the Government (see Article V): None.

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(FOR DIRECT AEC RESEARCH CONTRACTS) a. W,enever any invention o r discovery is made or conceived by t h e Contractor or i t s employees i n the course of, i n connection with, or under the terms of this contract, the Contractor shall furnish the Commission with complete information thereon; and the Commission shall have the sole power t o determine whether o r not and where a patent application shall be filed, and t o determine the disposition of the title to and rights under any application o r patent that may result. The judgment of the Commission on these matters shall be accepted as final ; and the Contractor, for itself and for its employees, agrees that the inventor o r inventors will execute all documents and do a l l things necessary o r proper to carry out the judgment of the b. No claim f o r pecuniary award or compensation under the provisions of the Atomic Energy Acts of 1916 and 19% s h a l l be asserted by the Contractor or its employees with respect to any invention or discovery made or conceived inthe course of, i n connection with, or under the terms of this contract. c. Except as otherwise authorized i n writing by the Commission, the Contractor will obtain patent agreements t o effectuate the purposes of paragraphs a. and b. of this article from all persons rho perform any part of the work under this contract, except such clerical and manual labor personnel as will not have access to technical data. d. Except a s otherwise authorized i n writing by the Commission, the Contractor will insert in all subcontracts provisions making this article applicable tothe subcontractor and its employees. The Contractor shall have full freedom of publication of the results of the research under this contract and the Contractor is urged t o disseminate the results of the work through customary scientific publication channels, except that " restricted data" a s defined i n the Atomic Energy Act of 1954 shall be governed by the provisions of Paragraph 3 of this Appendix WB". publications shall include a reference that the results were developed under a Commission sponsored project.

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a. It is understood that the work under this contract will not involve restricted data or other classified matter and that the Contractor will perform such work a sun class ui ed work. However, i f in the course of such work any discoveries are made or any data used o r developed that constitute restricted data or ather class l fled matter, the Contractor shall promptly inform the CCmmission and will be bound by t h e following: Contractor's Duty t o Safenuard Restricted Data and Other this contract the Contractor shall,in accordance with the sible for safeguarding restricted data and other classified matter and protecting against sabotage, espionage, l0SS and theft,the classified documents, materials, equipnent, processes, etc., as well a s such other material of h i @ intrinsic or strategic value as mlry be in the Contractor' s poesession i n connect i o n with performance of work under this contract. otherwise expressly provided inthe specifications the Contractor shall upm completion or termination of this contract transmit tothe Commission sion of t h e Contractor or any person under the Contractor18 control i n connection wlth performance of this contract. Inthe performance of the work under classified matter inthe possesRed at ions. regulations and requirements of the Camnission. The Contractor agrees t o conform t o all security Definition of Restricted Data.. The tern %stI.ictsd Data", a s used in this article, means all data concerning (1) design, manufacture, or utilization of atomic weapons; (2) the production of special. nuclear material; or (3) the use d special nuclear material in the production of energy, but shall not include data declassified or removed from the Restricted Data category pursuant to sec tim 142 of the At dc Energy Act of Security Clearance of Perso md. authorize, i n accordance with the Atomic Ehergy Act of 1954, the Contractor shall not pennit any individual t o have access t o Restricted Data until the designated investigating agency shall have made an investigation and report t o the Camission on t h e character, associations, and loyalty of such individual and the Camnission shall have detemined that permitting such person t o have access to Restricted Data n ill not endanger the common defense and security. Ae used in this paragray)l, the Except asthe Comnission mey

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term "designated investigating agency" means the United States C i v i l Service ComniSsian or the Federal Bureau of Investigation, or both, a~ deterndned pumuant t o tb propisions of the AtOaic Energy Act of 1954. (5) Criminal Liability. It is understood that disclosure of information relating to the work or services ordered hereunder t o any person not entitled to receive it, or failure to safeguard q Restricted Data or any tup secret, secret, ar confidential matter t h a t may come t~ the Contractor or person under the Contractor's control i n connection with work under this contract, may subject the Contractor, his agents, employees, and subcontractors to Criminal liability under the lam of the United a l s o Gxecative Oxder …