Supplemental Agreement - Contract No. at-(40-1)-1771, University of Arkansas, Modification No. 5 (Redacted)

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University of Arkansas THIS suPpLE?JENTAL AGREEMENT, entered into this a day of Cctober LjSa, by and between the UNITED STATES OF WRICA(here in after called the nihmrnmentft), represented herein by t h e UNITED STATES ATOMIC E;NERGY CoyLdISSION WHEREAS, the Government and the Contractor entered into Contract No. U- {&=i)-l'77l9 dated October 20, 1954, providing for investigation, development WHWIUS, the Contrast has been amended heretofore by Modifications Nos. WHERE3S, the Commission desires to provide for additional research a s more T;articnlm'iy described in TITUV of Appendix "A", t o obtain reports thereon, and t.s effect carJYain other changes asare hereinafter more particularly WHEREAS, tnis SuppLemental Agreement is authorized by and executed under NOW, THEREFORE, tne parties hereto do mutually agree that said contract is 'hemby msdfffed intne following particulars, but i n no others8 1, Tne fullmirig new section W5.W is added to Article 11: "so Tne period during which the work under this contract may be conf a Tne fcLicniEg new sabsection wl. e . " is added in Article 111: fie. IC e oc side ration of the performance of the additional work op seri b ~ e d ir. TITLE V of Appendix *A", and the Contractor's agreement t o supTh2rT;een and 52/1OC Do ii us ($27,U.52), the Government will pay t o the

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3. Subsection 2 , a. of Article XI1 is revised to read a s follows: wa. On or before the date of commencement of the work on the project described ir, Appendix " A @ ,the Government shall pay tothe Contractor upon scbmissioc by the Contractor of a properly certified voucher, & per cent of h e The following new TITLE "Vn is added in Appendix "A": This TI"IZ V desscr5ms the research program and cost estimates agreed upon between the Commission and the Contractor. %aD Scope and Plan of Approach: The Contractor will continue work on t h e dewlopment, evaluation and testing of tele therapy methods utilizing gamma irradiation from Cc?balt-&, for the clinical evaluation of cancer patients so treated, especial lv with regard t o the advantages, curative or palliative, over mce crmventional methods of therapy. The clinical studies will be carried out i n cooperation with the Teletherapy Evaluation Program of the Med9,zai Division, Oak Ridge Institute of Nuclear Studies. system cf grid therapy has been devised and p u t t o use and this approach will be utilized on advanced cases where only palliation is csnsey of the cervix. Inehded inthe work will be an evaluation of results on " a , Outline of Cost Estimates: (1') -S a i aries and Wages: Resemch Assibtants, Technician, Orderly, and Nurse 11,9 60.00 (U) Ma teri alas (6) Overhead (33% of sai aries and wages),

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nb. Items of property to be procured or manflactured by the Contractor, TN WXTNESS UHEREOF, the parties hereto have executed t h i s Supplemntal Agreement the day and year first above written. UNITED STATES OF AMERICA BY: UNlTED STATES ATOMIC ENERGY COMMISSION ACCEPTANCE BY SENICW INVESTIGATm the provisions of this document. I have read the foregoing Supplemental Agreement and agree t o be bound by

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University of Arkansas THIS SUPPLEMENTAL AGREEMENT, entered into this ;(:-.,b day of Fscerc3er i C A1957, effective as of October 1, 1957, by and between the UNITED STATES OF AMER (here in after called the flGovernment"), =presented herein by the UNITED STATES ATOMIC ENERGY COMMISSION (here in after called the l1Commission1l), and the UNXVERSI'I'X OF ARKANSAS (here in after called the "Contractorn); WHEREAS, the Government and the Contractor entered i n t o Contract No. AT- (h0-1)-1771, dated October 20, 19%, providing for ime stig ation, development and evaluation of radioisotopes for teletherapy; and UHEREAS, the Contract has been amended heretofore by Modifications Nos. 1 - 3 ; WHEREAS, the Commission desires to provide for additional =search as more particularly described i n TITfiE XV of Appendix nAn, to obtain reports thereon, and to effect certain other changes as are here in after more particularly described; UHEREAS, this Supplemental Agreement i s authorized by and executed under the NCW, THEREFORE, the parties here to do mutually agree that said contract is Atomic Energy Act of 1954; hereby modified i n the following particulars, but i n no other st 1. The following new section '5." i s added to Article I: 115. The Contractor shall commence the work as soon as feasible, prosecute it with due diligence and submit the reports Fequired hereunder as early as practicable, and not later than the dates specified in Appendix llCII.tl and the following new section .4." is added to Article XI: is hereby extended t o September 30, 1958." The heading of Article I1 i s changed from VERM OF CONTRACT" t o llSCHEDUI;E1f, "4. The period during which the work u der this contract may be conducted 3. The following new subsection "1.d.n i s added in Article XII: nd. I n consideration of the performance of the additional work described i n TITLE I V of Appendix "A", and the Contractor's agreement t o support that work i n the estimated amount of Twenty-Five Thousand, Eighty-nine and 92/100 Dollars ($25,089.92), the Government will pay t o t h e Contractor Ten Thousand

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b. Subsection 2.a. of Article I11 is revised to read a s follows: Ha. On or before the date of canmencement of the work on the project described i n Appendix *AN, the Government shall pay t o the Contractor upon submission by the Contractor of a properly certified voucher, 45 per cent of the agreed consideration; provided, however, that this payment shall be reduced by the amount of the balance, i f any, agreed t o be remaining unexpended from previous work under this contract." there for the word "worktt. In subsection 2.c. of Article 111, delete the word lttenntl and substitute 6. Section 3. of Article 111 is revised to read as follows: 'When renewal of the contract is desired, the Contractor shall submit tothe Commission's Oak Ridge Op rations Office a reneval proposal as orltlirred i n Appendix W n attached hereto. and the Cods sion shall then negotiate as to the amounts each will contribute for the additional research activities to be conducted, taking into consideration the actual costs incurred for the current work i n comparison with the cost estimates i n the contract, and, upon agreement, shall executs a formal modification of the contract." The fol lou ing new TITLE nIVw is added i n Appendix "This TITLE IV describes the research program and cost estimates agreed upon between the Commission and the Contractor. "a. Scope and Plan of Approach: The Contractor will continue work in tele therapy utilizing Cobalt40 as agama source to further clinical investigations and evaluation of treated tumor patients with regard t o the advantages, curative or palliative, of radiation treatment over conventional methods. The work will be apart of the cooperative program with ORINS entitled Teletherapy Evaluation, and Will include body cavity measurements, other appropriate dosimetry, evaluation of grid therapg, and other therapy developments and approaches.

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"a. Outline of Cost Estimates: Research Assistants, Technicians, Orderly, and Nurse 10,872 .oo (5) Overhead (33% of Salaries) : - Items of property t o be procured or manufactured by the Contractor, 8. Paragraph 2. Publications of Appendix "B" is =vised to read as follows: "It is intended that the Contractor shall have full freedom of publication of the results of the research under this contract ard the Contractor i s urged t o disseminate the results of the work through gcie nti fic publication channels, except that ' restricted datal as defined i n the Atomic Energy Act of 19% shall be governed by the provisions of Paragraph ?. of this Appendix rrBt'. "However, i n order to insure that the public disclosure of such results will not adversely affect the patent interests of the Government provided i n Paragraph 1. of this Appendix trB'c entitled 'Patents' appr wal for such releases hall be secured from the Comiission prior to any such " All publications shall include a reference that the results were developed under a Commission sponsored project.

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here to and made apart hereof is substituted there for. Dl WITNESS WHEREOF, the parties here to have executed this Supplemental Appendix tfC " 2s deleted, in its entirety and the new Appendix "CIf attached Agreement the day and year first above written. UNImD STATES OF AMERICA UNITED STATES A'DMIC ENERGY COMMISSION ACCEPTANCE Fi SENIOR INVESTIGATOR here to and made apart hereof and agree t o be bound by the pr wis ions of this I have read the foregoing Supplemental Agreement and the Appendix 'IC" attached

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3 0 200-word summar? of purpose Within 30 days a f t e r Q,:7 1 and scope with sx-mittal date !J., Complete Scientific Report On contract expiration or With renewal proposal if Three otherwise on contract expiration Report proposal i s submitted, 6. Brief reports or nanuscripts may be submitted as desired by A l l of tne above should be addressed to: Research and Development Division Oak Ridge Operations Office Post Office Box E Oak Ridge, Tennessee The progress report should briefly describe the scope of investigations undertaken and t ne significant results ootalned. It should also explain any significant d if - ference s between the actual level of activity (expressed i n the various categories of man-months, facilities procured, travel performed, etc.) and that contemplated be listed with bib lio map hi c references. should be appended ana nate rial contained there in need not be duplicated inthe Technical reports and articles prepared for publication should Reprints or pre prints of all such material Renewal proposals, if any, should accompany the progress r e p o r t and should contain the t:ype of infor,nation outlined belaw unless the information is already contained in earlier proposals or i n the accompanying progress report. change i n program o r scope for the additional work should be clearly explained and the cost estimated should be based upon past experience.

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Title of the project. De institution and department i n which the work will be done. Scientific background including literature relevant to the proposal, the significance, and the motivation. If the proposal isfor continuation of work already in progress the extent of present support should be stated identifying amounts received from federal agencies. Scientific scope ofthe proposed research, its objectives, its relation to present knowledge and t o comparable work i n progress elsewhere, and aplan of accomplishments f o r the work. tne institution,scientific experience, publications and accomplishments of Give the name, highest academic degree, position in the Senior Investigator(the individual who will actively direct the research program) and of each rdgdlar staff scientist who it i s proposed will engage devoted t o the project. project should be s o designated, and professional records given if possible. Indicate the approximate fraction of the time of each t o be Scientific personnel t o be newly emplayed for the the fraction of the time o f each t o be devoted to the project should be thesis is t o be related to the project. The number of persons o f each sub-professional grade and Graduate student employees should be identified as such if their Other Financial Assistance. involving the same personnel or facilities is to be proposed to,or received If assistance for this or other activities from other federal & non-university sources the extent of that assistance should be clearly stated, and the interplay of the arrangements should be Materials, Equipment and Facilities. work and justify t ne needrfor major items t o be procured. List those already available for the Travel and Other Items. anv other ma.ior items i n the budnet. Travel rates and the use of contract Explain the purpose of t h e proposed travel, and of f&ds for attendance at regular scientific meetings should conform with the policy of the institution in the use of its own funds for these purposes. Budget. 'his should list in detail all items of cost necessary to carry the project. It should include: alist of the individual salaries attri but able to the project, supplies and services, equipment (defined as things individually costing more than $500 which will retain their utility for more than ayear),travel, communication and publication, and the indirect costs all o cable to the project. The basis for computing the indirect costs should be briefly explained. B e budget should not include the stipend of fellows. All salaries chargeable t o the project should be i n accord with the established policies of the institution, or, i f not, an explanation should be submitted.

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11. Anount Reqaested. A statszeent of then art of the total amomt listed in the budqet wt?ich the institution is prepared to bear, and the amounts requested from the AEC, and a statement of any other sponsors of the project with the anocr,ts csn trim ted by each. ?he pronosal should be signed by the Senior Investigator and endorsed by a responsible administr at ive officer of t?e Institution. 12. State a ent of Current Expenditures. A current statement of its expenditures for the project, and an estimate of expenses toDe incurred. in the contract,as orought out in the report, may be reflected in the amount for use of residual funds. Any di:ference i n the scope of the work from that contemplated I f no new funds are required the contract may be renewed without A proposal for such renewal snould state the scope o f the work proposed Ihe radioisotopes purchase reports hall list all radioisotopes included i n the budget a t the regular price esta dished by the Commission, but which are purchased, or will be purchased under the current budget, at a price less than the established price by utilizing the discount authorized by an AEC Discount Certificate issued t o the Contractor. For each such Durcnase, the reports hall state the price as establi shed by the Commission, the price paid orto be paid using the discount, and the savings realized or to be realized. The report due on contract termination or expiration shall cover all sucn purchases actually made and not previously reported.

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University of Arkansas THIS SUPFUMENTAL AGIEEMENT, entered into this day of m&wernmentM), represented herein by t h e UNITED STATES ATOMIC ENERGY COMMISSION after called the Wontractarm) ; and between the UNITED STATES OF AMERICA (here in after c alix9 UHEREAS, the Oovernment and the Contractor entered into Contract No. 1IT- (&0-1)-1771, dated October 20, 19%, providing for investigation, development and evaluation of radioisotopes f o r teletherapy; and WHEREAS, t h e Contract has been amended heretofore by Modifications Nos. WHEREAS, the parties here to desire to extend the term of the contract in order t o continue the research activities previously undertaken, a s such extended program is described i n TITLE I11 of Appendix "A", and to effect …