Numerous Correspondences Pertaining T0 Renewal of Contract at-(40-1)-233 with Tulane University (Redacted)

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the Atomic Energy Commission. This ao2if ice tion Ln corporates t b - i rd period begin ni w February 6, 1952 &xde cCi z g Feb r Jam Investigator. The work in this third period,inad2it ion to conti cued study of data acc unu late d in the second per io2,will consist of 8study of the turn overrates of pot2ssiun,rub i dim and cee i un under cc n trolled diet a gmC therapeutic cond it i ol ? - s 8n executed copy 2nd one conf ome d apps of the cot if ice tion. receive z corL'ome2 copy for our files. TA an enclosing three executed co pie s1 1 of Mo2iZ ics tion So * 2 I a= won de ying if it would be pos sib k for this office to Yours very truly,

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IC0 ham puroharod 500 mioroourios o f C18* d t h tho oontraot which you ro kindly arrirtod us in ob tr lnh g from tho A.L.6. b h ~ r oo a r pleted the u ~ eof approxiratoly om-half of t h l r on throo subjeatr, bang fol lm d thorn at the horpltnl, for parid of .bout 75 d8p. Re are now ongagod i n the study of t h e r e dat. .before boginning< < our

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DIVISION OF B lOLO OY ANDY EDI CINE TO : Kenneth Kasschau, Director, Cffice of Research w Wdicine, FOR CONTRACT NEQOTIATION Thir letter with enclosure.,in triplicate,is sent in accordance with the procedure described in a letter from the General Manager t o all Managers of Operations dated 1. In st ltu tion : Tulane University o f Louisiana "'@mover Rates o f Chlorine and Rubidium Under Controlled 3. Title : Dietary and Therapeutic Conditions inPatients with Chronic Congestive Heart Failure and i n Control Subjects" AEC Technical Supervision : Medical Branch Becommended. Support: $7,000.00, including overhead a t 8% This yeer constitutes the fourth year of su?port, and the Cormittee has indicated that it will be,temir.al and at a level tion at the time o f negotiation. This should be celled to the invest cgc to rl s atten-

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In accordance with the provisions of a - 93(Revised March, 1950), and the requirements of the De classification Guide, the Division of Biology and Medicine has determined that the following security precautions should be taken in connec tion with the proposed research contract. Since there is essentially zero chance that restricted data will be required o r developed, no prs on nel security 10. Reports: (x) Reports are to be required as provided for byMemorandum Instruction of November 9,1949, on subject “ Direct Research Contract Reports ”. Progran Analysis Branch F i l e : White Copy ( w “ 1 Branch: White Copy ( w / oencl.

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Forwarded i s 2n appmved proposal for renewing Contract AT-(hO-l)-233 with the Tulene University of Louisiana for aEOther year, approval action by the Division of I3iology and Uedicine i s covered by Procurement Directive W-52-121 dated Januarg ll, 1952, in the mount The contract covers the project entitled nTurnover Rates of Chlorine and Rubidiun under Controlled Dietarg and Therapeutic Conditions in Patients with chronic Congestive Heart Failure and i n Control Subjects", The contractor has reported that there tarill be no funds available for partial funding of the new period, Accordingly, it is requested t h a t you prepare an appropriate modification to continue this contract on a 1- sum basis for another year and provi*e for t h e payment of $9,180. Since this contract period ended Februarg 5 , 1952, it would be appreciated if you could expedite this contract action.

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TO I Dr. Nathan Roodruff, Director, Research and Medicine, OR0 L. W. Tuttle, Assistant Chief, Medical Branch Thir letter with enclosures,in triplicate,ir sent in accordance with the procedure described in a letter from the General Manager torll Managers of Operations dated Institution: Tulane University of Louisiana School of Medicine Tltle : "Turnover Rates o f Chlorine and Rubidium Under Controlled Dietary and Therapeutic Conditions i n Patients with Chronic Congestive Heart Failure and In Control SubSbcts" AEC Technicai superviaion: Medical Branch Becommended Support: $9,180.00, including overhead at €% One year with provis&i for renewal

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In accordance with the pro virion r of GM-93 ,tRe ria ed March, 1950) and the require r nen rr of the Dec la sri fi cation Guide, the Di virion of Biology and Medicine h.8 determined that the following recur it y precaution r should be taken i n connec tion with the prop oae d research contract. Since there is eesentially zero chance that restricted data may be required or developed, no personnel a e our it y reauirements should imposed. Memorandum Instruction of November 9 , 1949, ()Special Report r In at ruc tion rare fol lor ~ :

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oolleuticnr of Uood cod urine w wort dr IW) th ct tho hziedikta concentsation-tine warn m d e c U l y cf all -rata ;xsocd r~adof Ucod for c pczlod of c.boct six weka

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ATOMIC ENERGY COMMISSION Tour proposal f o r a continuation of yuur reeecrch COI?- Chlorine a36 Eubicliub ucier Cor;trolleci Dietcry end Eicied F zi lure end iz Control Subjects" has been apadd it iom l year.

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UNITED STATES ATOMIC ENERGY COMMISSION DIVISION OF BIOLOQY A N D MEDICINE L. Ti. Tuttle, &st. Chief, kedical Branch TRANSHITTAL O F RESEARCH PROPOSAL FOR CONTRACT NEGOTIATION This letter with enclosures,in triplicate,is sent in accordance with the procedure described in a letter from the General Manager toall Managers of Operations dated 1. ~ n ~ t it uti on :The Tulane CxiTersity of Louisiana, School of Cedicine, Xew Orleans 13, La. "Tunover P,ates of Chlorine and Rubidium under Conwolled ()New Contractor &) Renewal of Contract No. Duration - From:One year with provisi88: for renewal for an Congestive Zeart Failure asdin Control Issued Ic $ Wgi its discretion8sto whether %Lis prcposal should be considered 8sanm pro2osal or a conti nut ion of tne It i s suggested that your office use

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Proporrl for Eupport of Eesearch Project 1, TITI,&$ Turnover rates of Chlorine knd Bubidiurn under controlled 2. IIXTXTUTION 8 Tulane University 6 c b o l of Medicine, beparbent University School of Hedicine, Hex Or leas, Loul.skn& Wore recectly, Efter 2ompletion of studles of biologic decty rztes for the long-life radiocbloride, C1 th At6mic Energy Comission for h u z n experiments, hccor fngIp, a sufficient qusntlty )rxs ob teh edt. ~ednFni6”YerXaCl3 mild and;Mosevere. Thus It k s been possible for the first -- flnie to neesure dlrectly t h e biologic decsy rates of-chloride - electrolyte. k lance, chronic heart fzilure, The aportence of physiologic problem relsked to tro gic zl and eu b tropic d enlfie metiibolism End to the present prepzrzitions for atomic warthese bio logic decay rates of chloride was recesured. The Influence of Ha, K, n t e r , bicarbmete, bromiCe, cortisone, and other agents upon the biologic Cecey rttes of chloride YES also CeteRllined. Sem and urhe sodlum, 30ta8sIum, end chlorido E S well as radiochloridewere measured stmultsneously.. Varla. on the sforementioned factors and wr i able s were recor‘deU.-‘ The d&y to day ver lat ions in chloride spece es well tis the relative eccnrecy of tbe various Ze th oCs of mezsuring. chloride letions ere_~vtiila.bl~-~c?.rre,unCer ‘ycrutiny at this tine. The The influence of chloride intake’fa the C i e t upon

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t o follow p ~ t & ftiu nla its m ttL boUc bthsvzor, elthough receatly it b s hen supgcrtec: that tt rasy for lov c ~ ~ ~ un. -+I( 1% laterested Ln studying the turnorer of potrssiun in t h e b e y of normal nan m d of peticnts with congestive hekrt ftiiurs, such direct oboemttion. purposes, It f a ?lenned, therefore, to obtkin petL ents with congestive hesrt fgilure ana observe tLes tbrou&h various st t gea of the eyndrone while Ehd.t epe ou sly observing c oz tro l subjects tions under cOndftIOII5 for net ~ boli cstudy, t kein ti - e e of ordinary Ea, C1, S end weter will be cont xl led, the oiit2ut will be a et sure d,ad the influence o f & gents mom to vLry R netzbalisrn end excretion rate ulll be observec. ior extzple, the izfluence will be condunted continuously until the injected materid. re&ches levels In the body too low t o be cou it e dnc cur & tely, of radlorc3iUlm out atthe blood will be okserv&d in oraer to obteln the pattern of t h e conteatr&tlon-tFme course curves. Subjects will be returned t o the metabolic kecs for the prolonged studies, Applicctions of verious theoretic cancepts developed from the studies k l t h raUoso&ium, raclomercury, and rsdfochlorfde w i l l be &?;lied. These ZZudies Kill cia not only fn the understsnding of rubidium zleteblism er?d rztes of turnover but, when correlated kith the simultaneous ineesurenents of ordinary potassiun, wI11 ~ 1 3 0i nd l cate the eccurecy with which radib&idima traces potasslum in the budy of m a . stuties should be of vdueh tmclerst&ndhg potsssiuar netsbolRbdiorubidium rnlght be used f a r zxch School of Engicm-r-g end Professor of MeCicfne

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Uneapeded PaC sra a i oic g in the Lice Insurance Nediczl Research Fimd Gxzt to the Cat-iov&sclllzr Lahr L tory a t Tulene Will be use& 30 defrey EOE ~of the sdaries of techalc fi as. plirtiR7y with selaries ht will be used primd-3.y for other vestigators dll rema the s-e as der tLe previous cantract,

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Michael Reese Ros pl t cl, Chicago, Illinois, Oct, 1, 1945-Jm. 1, Assistant, Department of Medicine, 1947-48 Instructor, Bepcrtm,ent of Wedicine , 1946- dbte I.ssis$ant Visiting Physician, Charity Hospitel, 1947-1950, Visiting Physiclen, Charity Eos pf bl, 1950- date. America kssocietlon for the bdvmcement of tc ien ce Anericm Federktion for ClSnickl fieseerch American Eeart Association Pew Orleans Academy or Science Orleas Parish Medicd Ioc let y ) Licensed to prs ct ice medicine Fn the Gtste of Louisiera since August 18,

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UNITED STATES ATOMIC ENERGY COMWISSIOH TRAHSIXTTAL, OF RESEARCB PROPOSAL FOR CONTRACT NEGOTIATION This letter with enclosures,in triplicate,is sent in accordance with the procedure described in a letter from the General Manager toall Managers of Operations dated 1. Institution : ?ha klme Lzirertiity of Louiriana, Sohool of ~ edi afn e, 6. AEC Technical Supervision : additicnal yum. Ke dio d Branch

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Proposal for Guppart of Research Project 1. TITLE8 lk or er rates of Chlorine and Rubidiura under controlled dieter y and therapeutic CondItiOnS h patients with chronic congestive he utf Li lure mci inc mtr ol sub 2. INSTXTUIIOR: Tulane University 6 c b o l of Medicine, Depertment of Medicine, Co rCio v & sc2hr fieskcrch Labor t tory University Zchool of Medicine, E e w Orleans, Louisirna 2nd mercury, Kith t h e use of Nz for normal man, for pstients with chronic congestive herrt failure ard for ppetlents with the ne ph roti c 6yndrorne. End €ig96s, k v e been meesured . More recently, efter conpletion of stbdles of bio logic deccy rztes for the long-life radiochloride, C 1 in the dog, pennlssion ms granted by ly, a sufficient quantity w2s ob td ned to edmbister hCl3 (107 CP# or 50pc) in wateF to 6 a i u l t fenele subjects -- 2 controis-ant3 4 patients with chronic congestive heert failure, -0 raild.Enit.&~- severe. . T h u s -it has been possible for the first time .to'&easTire directly the biologic dewy rates of chlorfde these rstes of turnover in czrrXovcsculzr adjustzent t o human physiologic problems relsted to tropiczl end subtropics1 environment as iiel.1 es to n o m 1 and ahol..Uctl water anU.electrolyte metabolism End to the present preparations for titomic w m - The Influence of chloride intake in the d i e t upon these bio logic decay rates of chloride was measured. The Fnfluence of Ha, X, uzter, bicarbonate, bromide, cortisone, and other agents upon the biologic deczy rates of chloride WESel so deternined. .Sem aod urine sodium, potessirmi-;L'-and chloride ES well es radiochloride were necsured simultsneously. Varistians in the chloride coapartnent of man end thefr influence on the aforementioned factors and vzriables were recorhed. The day to day vzriations in chloride spzce 2s well as the reltitive accnrscy of the various raetSo2s of me as url ng dc No ride compartments were cietemlned. Eiace the experiments were coaducted for 30 to (sbont 90 consecutive dzys, one normel znd 2 ~ b - lstions Ere av zila b lead zre weer scrtitiny 2t this the. The

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detail8 a11 be published 8 8 indicated. odr a fev aspect# of the llndingt are presentea In this progress report f o r 3 subjects whose datb hhve thus far ken partially Enalyzed. Frequent collection or sm?les &t short lntervels course of cuor l deh s eru tnd urine cnd xsde possible an estimation of the rste of ex chi age of chloride &cross the mscular wdls,defined for the coll tro l sukJect by the multiple Elood samples were collected dLlly end E;tecimecs o f were collected septirctely 5s passed o r withdrawn. ments yielded the folloulng dgta : (1) X i ' t e i equilibrium of Cistributioc had been reeched, the serum concentretion fell to one-half (C:) in 15 d ~ y sin the heart frilure end about 45 deys in the subject uith severe concontrol scbject, 19.5 dsys in t h e subiect W - i th mild congegtive the urine U;5) and also from all routes of elimination (El) 17 and 16 deys respectively for the control subject, 48 &id 38 deys for the Enbject in zd12 %:lure, a d 169 &rid 65 days for_ the subject in severe fcllrt-e, were 96, 69, and 48 per cent-respectively for the 3 subjects, (4) Frcm the theoretic cox icier sti oo 3~ t-xmove? rates a d the influenyj of compartment size ?resented in previous st dies with >,le ama ~nci~ 1 3 6iz? iog;, it WET found that tile bio logic dec q r&.tesbekve2 according to ezpectEtions and previous mthematic21 esilmticcs. m d &rugs I nercurlal diuretics, DCA, czthzrtics) 2nd vEriEtions .fn the stzte of fcilure were found to influence the bio logic decay rates of chloride. Rov tkt we have info m tion on the bio logic decey rztes of soClu91, mercury ad chloride for normzlmzin and for patients with chronic cozgestive hezrt fzilure, it is plaried to zp2roach the bio logic decsy periods of potassium by mems of rcdforubiCium and ~ l s ot o throw light upon the acc tr t cy kt th xhich this isotope tr;ces pot es rim. Ferrdssion hzs LlrehdY been obtzined fron the Subcozmzttee OT; 3uiia Lgpl i cz t ions to study n a xith rsdiorubieiuz for the first tine. op in im of nost 2hysioiogists iriZ chezists thzt rubidium tends

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to follou potbsstm la i t s netrbolic behavior, slthough …