Minutes, Advisor Committee for Biology and Medicine, 22ND Meeting Held at Argonne National Laboratory, May 12-13, 1950

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Advisozy Convnittee for Bio loa ad. lkclicine Ths twenty-second meet be of the Advisory cornnittee f o r diology and M,vdicine was held on Friday and baturday, May 1 2 and 13, 1950'<at-U:e\Argonne National La bra tory, Members of Committee Dr. Alan Gregg, Chairman attendance. Appt. Dr.Curt Stern of Chicago, and Dr. R. B. Has ter li k Argonne National D r . 14. Hilberry

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Dr. Austin Brues, Director of t!ic Biology Division of Argonne National Laboratory provided an extensive tour of the laboratories. Division, Radiological Physics and Health Service Division and t h e Toxicity Laboratokes. The work in process inthe Biology A%asit was made t o the Billings Hospital The following individual programs were presentzd: of methods of handling experimental animals, Dr.S.Phyllis Stearner - Effects of Xi rr cdi ation on newborn rats - production of opa cities of the lent2 of the eye. experiments - toxicity of polonium. Mr. 3. A. Tyler - Outline of work i n biometrics on planning and evaluation of experiments. of dosages from various radioactive isotopes. ments of X-ray dosage with a i r mesh chamber and photointhe human body. Methods of determination of radium constant cultures and. dialysis bags. Chilomonas as affected by treatment. Growth of C paramecium i n mass Microscopic appearance of Factors in radio sensitivity - induced radioresistance.

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tion darnage by means of sulfhydryl conipounds. substance and fibers by electron microscopy, Dr, Janet Passonneau - J pve stig ation of kinetics of molting fluid in cecropia moth usGg C-14. Particle effects of B irradiation on rats. Abnormal tissue growth. Soft x-ray effects on mice i n which the dosage was varied inversely with t h e surface exposed. metabolic processes of the rer;ting cell. oxidase system caused by X-irradiation. changes in irradiated cells. Increase of an relationship in higher plants. X irradiation and photogrowth hormone action. X irradiation effects on cell in activation of bacteriophage. measured i n Py aurelia. of nitrogen mustard i n -P. aurelia. - Use of radioauxin in study of the mechanism of X-ray effects on mating Physiologic and genetic effects strontium, radium, etc.) and phosphorous. measurements and hot laboratory techniques. at very l o w dilutions. around point sources of B rays. Distribution of ionization in air

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Treatment of radioelement poisoning. ions of biological importance. Physiology and therapy of irradi:t ion s:mdrome. Studies on blood ana blood-forming organs. Toxicity Laboratory (University of Chicago) program. Radiobiological research. The Chairman convened the meeting a t 9:OO a.m. and presented t o t h e Committee the minutes of the meeting held a t t h e Atomic Energy Commission on March 10 and ll, 1950. The minutes were approved unanimously. Report on Support of fiesearch Projects. discussed the subjects and budgets of the research projects which had been approved, reviewed o r declined by t h e Divis i o n of Biology and Medicine during March and l!pril 1950. - . ._ The list of such projects is available in the files of the Division of Biology and Medicine.

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N e w England New Engl<yid Deacones, Hospital Contract. Ds. Shields Hospital Warren aid I)r. A, Baird Hastings left the room while tkie New England JJeaconess Hospital contract which was considered atthe meeting held on March 11, 1950 fas presented by Dr. Dunham, The committee approved unanimously the contract as w$4tten and expressed the hope that the work should be started at '.a &ly date. Yale University Proposal. ing support of the AEC to establish an institute of radiobiology costing three to four million dollars which would serve t o provide a number of facilities for work i n biology, Dr. Warren presented a proposal medicine and agriculture. The proposal involves a cooperative program for training foreign workers inthe use of The Committee expressed strong feelings against supporting such a project, and they were of the opinion that the AEC has supplied sufficient funds for training Chicago Operations Office. t h e Research Program outlined the program of the various contracts handled by the Chicago Operations Office. The Committee was interested in the statement that the Chicago Operations Office administered between 100 and 110 research contracts which had been approved by the Research Division

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and t h e Division o€ Biology and Medicine. The question of overhead w a s discussed. i’L. .-.:as brought out by the Committee “ that even i n groups of undertakings o r types o f undertakings we are still not a t a place where uniform overhead should be taken as standard.” Dr. Skinner concurred with this statement. An extensive rev,&w‘i%asgiven of t h e krgonne National University University of Chicago. Mr. ii. B. Harrell spoke b jie fly on of Chicago- the cooperation that exists between the Universitjj of Chicago <and the Argonne National Laboratory with particular references made regarding the Argonne Cancer Hospital. relationship between the University and the Laboretories. Dr. Coggeshall told of the need for the hospital and explained the structural details and the plan of its operation f o r which bids have now been requested. Coggeshall read into the record the following outline of the operational.; plan: “The purpose of the hospital, as set forth in the contract, isto provide facilities for clinical investigation and experimental work in the field of cancer with radioactive materials, and other sources of radiant energy, including such biological research ancillary thereto as may be indicated; the advance training of personnel i n such

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f is lds, and assistanca t o elid collaboration nith the Commission, tho Brgonne National Laboratory, a:ld i t s participating institutions, and other cooperating organizations in t h e work of the hospital. The regular services of the hospital will be provided by the University, and the cl&.$cal services, which facilities are not provided in this building. admission and discharge of patients, routine X-rays, clinical, pathological diagnostic examination, f-d, .-:\ Such services include t h e laundry, regular housekeeping service, drugs, nonradioactive therapy, reference library, and .so forth. If It is understood that the use, policies, and practices concerning the admission of patients to other units of the University Clinics are to govsrn the admission of patients to this hospital. hospital for routine medical care. a more detailed listing of items of reimbursement for service, will, of course, be set forth by the units doing the operating contact. The responsibility for furnishing Patients will not be admitted tothe It is understood that routine medical and surgical services shall rest with the "The research program of the hospital will be carried on by the membbrs of the medical faculty of thc? Univzrsity, representatives of the hg on ne National Laboratory, and its. participating institutions, and other cooperating

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organizations arid institutions. It i s undcrstood t!i;.t members of the clinical staff of the School of IPjedicirIc, and members of the s t a f f of the lirgonne National Laboratory will constitute the principal components of the permanent staff of the hospital, but other qualified members, such as ':$e participating members of Brgonnc, may constitute a par% of such permvlent staff. "The appointments t o such professional research staff will be made by the Director, with the adv ke of t h e \ medical advisory committee. ffApplications for proposed projects by members of participating institutions of lirgonne, and other cooperating institutions, will be encouraged by the University, and submitted tothe bean of the Division of Biological Sciences, who with the advice of the medical advisory committee, shall approve applications and establish priority of projects. All such applications and the participation of all such cooperating members inthe program shall be subject to rules and regulations cons is tent herewith, establish by the University with the advice of t h e medical advisory committee, and concurred. i n by the Commission. NOW, the administrative set-up will be: ( a ) The administrative aspects of t h e medical-biologicd program of the hospital will be under the direct ' control of the Dean of t h e nivision of the University of Chicago.

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(b) The ad n in is tr at or, under title of the Dircctr r of the krgonne Cancer %search Hospital, xi11 have two assistants, one of whom will be chosen from tho clinical faculty of the School of Medicine of the Universiiy, and t h e other designated by Argonne National Laboratory from i t s medical and b$Q$ogical staff. bo assisted b:y the Supe&-&mdent of the Univcrsity Clinics. The Director will also (c) There shall be a health physicist, who will be assigned two physically and technically qualified health such rules and regulations i n an effort to properly protect He will be responsible for the enforcement of all personnel from health hazards; t o properly shield radioactive materials being used or stored on tho premises; t o safeguard the building and equipment from c cnt mi nation.. by radioactive materials; t o properly protect patients and their.visitors from undue exposures to radioactive materials; and t o exercise proper precautions in the disposal of a11 radioactive refuse, sewage,,and other discarded material. “The medical advisory committee has been appointed. It consists of Dr. Andrew Ivy, University of Illinois, as Chairman; D r . Smith Freeman, Northwestern University, member; Dr. Cecil Watson, University of Minnesota, member; Dr. Coggeshall, ek officio member; and Dr. Warren, ex “The committee will consist of five members, with t5ree

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members s elz c ted from the participating in st it2tio m cf thz Argonno National Laboratorj. m d cther coop cretin g in st it u - tions ; the other two members to consist of the Dzm of thz Division, and a member of t h e U. S. Atomic Energy Conn-Assion orhis authorized representative. Ucmbers of the comiiittGe, including those rebyired to fill vacancies, shall be of Governors of t h e Argonne National Laboratory and the clinical faculty of the School of Medicine of the Jniversity, and with the concurrence of the Commission. The terrns of offices hall be six years, except that with respect to the members constituting the committee at the the of its adoption of the plan, the term of office of the chairman shall be six years, and the term of o f f i c e of Dr. Smith shall be f o u r years, Dr. Watson, two years; and all members whose terms of offices hall have expired shall be .eligible “A close integration is planned of scientific matters and problems with t h e work i n the Goldblatt Hospital and the work inthe Argonne Cancer Hospital.!’ Dr. Brues spoke on the need f o r tho cancer isotope hospital which he believes i s necessa-y not only from the technical point of view but from the standpoint of dcveloping a mode of thinking on radiation therapy of cancer which has not been quite accomplished elsewhere.

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Hc, gzve a bri af summary of resmvch progrcss k non-classified bibliography is hcing prepared of literature on RVi and related subjects. Argonne Argonne National h borat cry.Dr. Hilborry welcomed the Laboratory Committee i n Dr. Zinnls-'ibsencc. The Committee was interested in his oral report on the growth and dcvalopnent of the Laboratory since its inception in 1942 toth e- present. Dr. Brues spoke briefly on the general orientation of .the biology program with emphasis on the main line invest i - gations and exhibits, i.e. the investigation of neutrons, the particle problem and other rad.iobiolGgica1 pro-T rams. H e closed his remarks by reading the following paragraph 13r. Lionel Trilling which Dr. Brues believed applicable tothe complex research programs atthe Laboratories: W e must understand that organization means delegation a d agencies and bureaus and technicians, and that the ideas that can survive delegation and that can be passed on t o agencies and bureaus and technicians are inclined to be ideas of a certain kind and a certain simplicity. They give up something of t h e i r largeness and modulation and complexity i n order t o survive, the lively sense of contingency and possibility, and of those exceptions tothe

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status of the biology build bg. Dr. Jarren and Dr. Powers review d the Thzy s tz ted that plans have becn completed and that bids areto b? requested for tha building the first w u & - ' in June. Dr. R. J. Has ter li k discussed the activities of thoc Xedical Inthe absqnce of Dr. Hermann Lisco, Service Division which consists of the Health Servica Group, the Radio-biochemistry Group and the Uccupational Hygiane Diks ion an outline of the important work that is now being carried on under t h e Radiological Physics Division. included the work of the research secti.cn under the direction Research Research Projects by Graph. Dr. Warrm dcscribdd the work Graph of the Division and individual budgets of t h e programs by a graphic presentation of t h e research and devclopmmt programs. The Committee expressed many commendations 2s ts thL m o r i t of these charts. The Committee adjourned for lunch a t 12:3O p.m. and

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Biology and Uedicine concerning the establisknant of a training program for industrial physicians. sense of the Committse that the need is critical md that such a prograrq should bc startcc! at the oar lies t date. The prcposal was. approved unanbously with the understanding that an emolum-.nt of $3600 should be paid for thc first yeaof training and JSOOO for the second year of tra9ing. It was moved and scconded t h a t the University of Rochestcr would administer the program, i f feasible. isto be the responsibility of the Directcr of thz Division t o follow other possibilities for its administration. Directcr, Task Unit of t h e Biomedical progrm, gave ul interesting review of the progress t o date on plans for the biological experiments as apart of the next w$zpons test are excellent and that he has r xe i ved overy coopzration from the Army, Navy, kir Fcrce and the VG turm s recent discussi'ons pertaining to the 1951 budget reviews for biology and medicine a t the Argonne Watimal Leboratory, He stated thrrt the review had brought 2 reduction inthe

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research progrms"-??t up on a two-year basis and a t the end of the first year ,rc&& them for another year. kco Program.- Dr. Claus outlined the medical, health physics and background survey programs a t @co, The heala physics branch is t o be under the supervision of the rnedicil. sarvice a d as now organized will be operated as a central iz ad function of the LEC rather than by individual contractors. Atomic Bomb Casualty Commission. the s tz tus of the hBCC program and the staf'f paper which was t o be presented tothe Commission for thc ir considarationt The prGgram calls for an annual operating cost of apprcximately $2,500,000 beginning FY 1951. Aftcr 2full.discuss im the Committee agreed t o approve the proFran as it was la tion of the program …