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Advisory Cormittee f o r Biology and bkdicine The twenty third neeting of the Advisory Committee f o r Biology and Fedicine was held on Friday and Saturday, September 8 and 9:at the Atomic Energy Commission buildDr.Alan Gregg was unable t o be present. Staff of AEC and I&. Gordon Dean Division of Biology and Medicine Mr. John A . Uerry hir. Beverly Thompson Visitors Dr. N. Voodruff, Oak Ridge 0. 0.
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The first order of business presented tothe Cornnittee by the Chairman was a discussion of the minutes of t h e meeting held 1950. Upon a motion by Dr. atthe AEC on Uay 12-13, Bronk and seconded by Report on Support of Research Projects The following projects in biology, medicine, and health physics, that had been selected since the previous meeting by t h e Division of diology and hjedicine t o receive support by the' Atomic Energy Commission were studied by the Bomrnittee. Dr. Xarren conmented that the number of 83 approved contracts may seem t o be high, however, it did notre pre smt undue acquiescence in requests, but rather it is a reflection of the fact that there were certain specific holes in the biological, medical and health physics programs that needed t o be filled and '- the Division had been working hard to interest various Pollard - fl Irradiation of Viruses and Large Moleculesft (Approval of renewal of contract for period Jun 1, Previous contract June 1, 1949
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hydrate Ainino Acid Interrelationships, Using Is otc pic contract NR-1’25-930 for period July 1, 1950 t o June 30, 1951. Previous contract July 1, 1949 Accumulation of Inorganic Materials by Algae!! - $14,202. contract NR-130-742 for period July 1, 1950 t o Under ONR contract FY 19h8 - $6600; (Approval of renewal of contract for period July 1, Previous contract July l, Less unexpended funds
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(lipproval of transfer to LIEC and renewal of ONR contract NR-171-642 for period July 1, 1950 t o June 30, 3-9'3,. Previous contract under ONR FY Dr.Max Kleibor - Wetabolism Studies and Biological (Approval of renewal of contract for period July 1, Previous contract f o r period Total ImmJ(Transfer t o AEC and renewal of ONR Contract NR 164-879 for period July 1, 1950 t o September lh, 1951, contract under ONR $12,315). (Approval of renewal of contract for period July 1, 1950 Previous contract for period Julyl,
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of Miner d Subst aces in Plants " - 82,530. (iipproval of transfer to l.SC*-Gd renewal o f OIdR contract NR-122-725 for period July 1, 1950 t o June 30, 1951. Previous contract under ONR - $1753). of Action of 2,4-Dichlorophenoxyacetic kcid (2,h-D) and Totd. rn(Approval of transfer to EC and renewal of ONR contract NR-171-786 for period July 1, 1950 t o June 30, 1951. "The Use of Radioactive Isotopes i n Studying Mold Metabolism with Emphasis on t h e Assimilatory Mechanisms of Penicillium Chrysogenumfr - $4,250. (Lpproval of transfer to AEC and renewal of ONR contract NR-130-812 f o r period of Junels, 1950 t o June 14, 1951. (Approval of renewal of contract f o r period June 1, 1950 Previous contract June 1, 1949 t o
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(Ren wal of contract for period July 1, 1950 to June 30, Previous contrclct for period July 1, 19b9 t o (Renewal of contract for FY 1951. Equipment and Supplies 1,465 (Renewal of contract for period October 1, 1950 t o State College of Washington (fiT(l&1)-213-1) Dr. 0. disposition of various elements in Plants ff - $2,520, Previous contract for period (iipproval of additional funds t o amount previously approved; Contract ” pril 1, 1949 t o March 31, 1951,
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"The Effect of Radiation on Intestinal Absorption and Metabolism of sats and Carbohydrates'' - 37,181. (Approval of additional $7,181 t o sum of 423,382 "The Effect of.Ultraviolet Radiation on Enzymes and Effect of Labelling the Germ Cells on Fertilization ment i n Tradescantia and Gane Mutations i n Neurospora" Personnel $1.1,100; Equipment eC Supplies 325,850;
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"The Long Time Effects of intermittent Radiations (27) Stanford Research Institute - Drs. 8. Pencharz and D. Singman - ffknh per inen tal Study of the Direct and Indirect Effects Produced by X-Irradiation of the E.I. Whitehead - flldetabolism of Selenium and Sulfur Equip ent & Supp li is 3; 465
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Smu els - "The Use of Labelled Phosphorous i n the Study of Wer& Tissue Metabolism During Invasion of Wutagenic Effects of hi ffe rent Types of hdi A ion " Equipment icc Supplies 500 Effects of Tiadiation on the Differentiated Chromo2, 4-D and Other Growth Regulators in Plants in Ljght
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(35) University of California, Citrus Lxperiment %tion - University of Utah - urs. John D. Spikes & +. v i . Lumry by t h e Use of dadioactive Carbon Compounds" - $8,640, Effects Upon Haploids and Diploids of Habrobracon'l - Equipment Et Supplies 550 of Genes t o diochemical Reactions i n Neurospora1' - !$5,415,
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(Renewal of ion tract for period July 1, 1950 t o tions of the idechanisms of ht i body Synthes-5s by the Pr dous contract July 1, 1949 t o (iipproval of additional funds t o $4300 previously approved: (Renewal of contract for period July 1, 1950 t o and Plasma rrith Mitrogen Mustard" - $12,900. (Renewal of contract for period July 1, 1950 t o June 30, Previous contract July 1, 1349 t o June 30, 1950
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Total m '(Renewal of contract for period July 1, 1950 t o June 30, tion on the Functions of Lmdl Blood Vessels ofthe Hamster and t h e Frogff - :~5,000, Previ;ous contr2ct for July 1, 1949 t o June 30, Sing el - "The Effects of Nutritional Deficiencies on t h e Synthesis of Phospholipids and Nucleoproteins in (Lpprovsl of additional 32,600 t o $5,600 previously Risley-"Localization of h dio active Isotopes in Germ Cells and Reproductive Tissues during Quiescence and (Renewal of contract for period July 1, 1950 t o June 30, Previous contract for period July 1, 1949 t o
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for pcriod July 1, 1950 t o June 30, 1951. Dixon - " Investigations of the Zffects of Lgents Used in t h e Treatment of Culcer, X-rziy and Nitrogen Mustards on Immunologic Hesponse t o Experimental (Ronswal of contract for poriod Sopt. 1, 1950 t o Previous contract f o r Sapt. 1, 1949 If6pplication of dadioactive Tracers i n Field. of Cellular Equipment ik supplies 1,550 .Overhead 550 (Renewal of contract for July 1, 1950 - June 30, 1951. Previous contract for July 1, 1949 - June 30, 1950 IfBiologiczl Synthesis of t h e Peptida Bond" - 39,400. Renewal f o r period July 1, 1950 t o June 30, 1951)
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(Previous contract for July 1, 1949 t o June 30, 1950 figcnts with Lbdioisotopes Critari2. for Eosage Toxicity; (linal breakdown on budget not available) or" cont rsc t for period July 1, 1950 - June 30, 1951. Radiation on the Distribution of Phosphate i n Red (Renewd of contract for July 1, 1950 -June 30, 1951. Previous contract for July 1, 1.3119 - June 30, 1950 - of the Toxicity of & ry lli um fl - $50,386. Gest - Whemistry and Metabolism of some Sulfur Oxidesf1 Equipment uh ppl ics 1,750 Tot<?l --(Renew21 for period of July 1, 1950 - June 30, 1951. previols contract July 1, 1949 - June 30, 1950 - $11,753).
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(19) Cedars of Lebanon Hospital (Contrzct LT(O4-1)-290 (l~pprovalof extension of contract f o r 2 months for July 1, 1949 t o June 30, 1950 - 37,500) (Renewal of contract for period Oct. 1, 1950 t o Previous contract for period (Previous contract for Scptembw 1, 1949 t o hug. 31, Renewal for period Sept. 1, 1950 t o Radiation Hemorrhage and Other Hemorrhagic Diatheses in Patients and Experimental imimals“ - $1,050. (qpr oval of add it ic nal funds t o previously approved
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Phcsyhcrcs 32 fc r the Precise Localiznticn of Brain (Renewal of contract for period bug 1, 1950 t o July 31, 1951; Previous contract for period Lug. 1, (Dr. Shields Yiarren discussed the initiation of this project by telephone with members of the Committee and he received their unanimous recomnmdations that this project shculd be approved.) !'Physiological and Pathological Investigations of
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uf t h e f,bsorption 2nd iletabclism of Lipids and Alter nti cns which uccur i n Acute ltadiation Injury" the Particle Size Dependence of hro sol Retention i n Ihr v in aotwick - ffResea-ch and Devjlopment on a (31) North Carolina State College - Ur. Donald B. finderson inthe Tissues of Intact Tree species " - $2,335.
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IIIlse of a IJicrcbJnm of Light h tonic Iiuclei for (Transfer t o !EC and rcneivnl of ONR Contract IIR-171-256 for peric.d July 1, 1950 t o June 30, 1751. Less uncxpmded funds 2,100 (Rsna-ual for per is d hug. 1, 1950 to July 31, 1751. Previous cc n tract for Jkug. 1, 13h3 to July 31, 1950 to July 31, 1951 without edditiorixl funds. Pr;.vious contract for period l q. 1, 1949 t o July 31, 1950 for July 1, 199 tc; June 30, 1951. Frrvicus cmtr. ? c t
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(cc n tract rcnownl kr July 1, 1950 t o Junc 30, 1951. NR-171-645 and 1IR 171-6t3 for July 1, 1950 t o
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Equ ip e nt & Supplies 2,200 His tor adic gr q hy in &lztic;n t o th; .I:istributj on of
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Schnee - "Absorption and Assimilation of Radioactive Wastes by Water and Sewace Slimes." Idetabolism of Phosphorus i n Beef Cattle Using Radioactive phosphorus-32 as a Tracer - $6,699. ltl.~etabolisrnof, Phosphorus by Larval Nematodes 94,886, Baird Associates, Inc:. Cambridge, dass a chu sett s - Investigations on the Localjzcd Effects of HadiLtion Dissemination of Informa tion D i s scmin at ion of information gleaned from the research pro j z ct s, aqd laboratories and as wcll as how the pamphlet l1N\ic1carScS5nce Abstracts" could be mor2 wid* circulated and be made more Ur. Bronk suggested that it might bd w sll to in it i atz an opa rational rescarch program throueh the NRC as tothe various types of piiblica tions and th air relative cf fdctivcness in order t o see just what is b2ing accomplished with the dissemination and utilization of sci mt if ic in form tion.
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The Cornnittee approved of this proposal and of this type of investigation and they will look for wad to definite suggestions from br. Bronk on how t h e Committee and the Division of diology and Medicine may cooperate i n this Radioisotope Radioisotope Traiqing Courses C ours e s Dr. Nathan Woodruff..of the Oak Ridge Operations Office sought the view of the committee as t o expanding the basic radioisotope train j ng courses to universities and colleges in the larger metropolitan areas by assisting them financi ally in creating facilities whereby they could train persons inthe handling of radioactive materials. It was the sense of the Committee that even though the objectives as set for.th by Dr. Woodruff seemed t o ba desirable it was their belief that the present training course programs as now established are adequate. The question of broadoning t h c scope of research with free radioactive isotopes, rather than restricting thcm for use i n cancer resGarch was fully discussed. The Committee wished t o be placed on record as bcing i n favor of using free radioactive isotopes for all types of research which may be described a s fundamental rosearch including chzmistry, biology and physics, Idaho Reactor Idaho iieactor Test
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