Memo to Commissioners and Division Heads, Subject: Meeting of the Advisory Committee for Biology and Medicine

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ners and Division Heads' The sixth meeting of the Advisory Committee for Biology and Uedicine Invitation Ys cordially extended to attend this meeting. _- ' 1. Correction of Mi&es of December 13, 19b7 kketing: The statement that the request for support of a research contract by D r , ' Allen itloritz was approved, should be deleted 1 from these minutes.. I I2. Additions t o the Minutes.of the ke ting of the Advisory e suggestions e meetimg of the Advisory. , discussion be 'included in the Idinutes of December 13, 1947 regardfollowing material be added tothe uinutes of that meeting: ing the Isotope Distribution Committee, it i s recommended that the 1On October 30, 1947 it was announced that ' the Interim Advisory Committee on Isotope Distribution Policy and two subcommittees wished t o resign. AccordlnLly, a new cornlittee on Isotope Distribution was proposed by the Isotope Distribution Brmch of the Atomic Energy Conmission.

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that the new committee of the follo ~ n gpersons who are closely associated with the use of isotopes: Gioacchino Fail la, Ph. D,, Professor of Radiology, Columbia Lakesidc Hospital, Wastern Reserve University, Cleveland, Ohio. Operations, Atomic Energy Commission. ment, University of California, Berkeley, California. Washington University, S t . Louis, ldissouri, Robley u, Evans, Ph, D., Professor o f Physics, Masskchusetts Institute of Technology, Cambridge, Massachusetts. Carnegie Institute or" Technology, Pittsburgh, Pennsylvania. ' tory, University of Chicago, Chicago, Illinois. Paul C, Aebersold, Ph, D., Chief, Isotopes Division, as Secretary tothe Committee and Liaison Representative of the Atomic Energy It is suggested that Dr.Fail la be appointed Chairmm of the The proposed functions of this committee would be to aid the Commission i n establishing new policies on the distribution of radioactive materials and t o review from time t o time existing policies. On specific isotope distribution problem it i s hoped . the members ofthe main cormnittee would function as two subcommittees whose personnel and functions are given below. committee on - Hui ian Applications who would review all initial requests for radioisotopes t o be used experimentally o r otherwise purpose would not be reviewed. Subsequent requests of a given user for the same D r s . Hamilton, Kennedy, Evans, Idehl and Brues should compose a Sub-comittee on Allocations and Distribution who would revicw

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doubtful re q k sts for radioisotopes -to be used i n fundamental and applied research, the field of education, in dust rid - applications, and commercial. enterprises; The Isotopes Division would assume responsibility for alloc3tions of isotopcs except for those cases specifically noted i n pzragraphs four and five. Because of t h e expericnce obtained during the past year and half of the program and the initiation of a field service on isotope tcchniques, tho Division is well qualified to hanclle this responsibility. During the past few months it has been handling the routine work of allocation with a minimum of assist m cc - b y the advisory However, the Division has had t o rely on the subcommittees for assistance on difficult dccisions. -Wormation has been drawn from a Staff Paper which was submitted t o the Atomic Energy Commission by the Xanager of the Consideration o f Minutes of the Zdeeting of January 9 , 1948, L&g& Vice Chairman Goodpasture and the Interim Director of Biology and Gdi cine have recently discussed the general problan of support & ~ f , has recently conferred with Admiral Lee, Director of Office of Nzval Research. The General Advisory Committee has outline its a

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I A rcsearch contract between the above-listed parties,, negotiat ions for which were initiated last sumner, has been entered into for the purpose of studies o f nucleic acids, nucleoproteins, nucleotide and re?la&&:orgmic phosphorus compounds .in such a manner as t o gain fundmental knowledge. of t h e nature of disturbLance of these compounds i n orLanisms exposcd t o ionizing radiations. pro j act is supported t o the extent of $29,500. ' -4 second contract is for the construction of an ultraviolet '. spectrophotometer and an ultraviolet microscope fora study of the , I work will cost $h5,5OOe+ It 'is estimaied that this This isa request for supportlfor a program of research on Vhe Biological EIffect of High Voltage Radiation" using the facilities of the General Electric Coq any, Schenectady, k w York. .will involve a range of one mil1ion:to one-hundred million volts as There i s only one other similar . emitted by the hundred million volt betatron, with financing mated for this s1ol.k t o be $ RECOIL~DI?TION: It i s &omended that the Advisory Connittee for Biology and Zedicine approve that the Office of Naval'Research be notified that funds i n the beginningamount Of !&P=y 1, 1948 for the support of a research project at Union College i n cooperation with General Elec tric Research Laboratory, Schenectady, New York, by Dr. Leonard B. Clark entitled !'The Biological E$f ect of High Voltage b are available for one year

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This isa research project on '!The Effects of Radiation on Reactions Associated with Growth," For many years this laboratory has worked on t h e catabolic aspects of metabolism, with support from the National Czncer Advisory council ,dxational Research factors,chiefly hormonal, on thzse reactions; They have considered t h e effects of gro-xth-influencing They have studied the capacity of the liver to synthesize alanine fro3 pyruvic acid and a considerable number of similar-reactions. They wish t o , de ted ne the effects of radiation on such reactions in normal tissues and i n tumors. RECOI&~.WATION: It is recommended that the Advisory Committee for Biology and k di cine approve that the Office of Naval Resew,ch be notified that funds inthe mount of $15,000 are available f o r one year beginning July 1, 19b8 for the support of a research project Rapport entitled "The Effects of Mi ation on Reactions Associated with Growth Howard University - Dr, Herman Branson: f This department requests $11,400 t o support studies in bio- *at Howard University from li January 1948 through 15 Janmry topes including a 60' Nier type mass spectrometer with t h e nost recent refine pints is projected. on phosphorus metabolism with P3*, determinztion of rate functions k progran of investigation with radioactive and stable isoStudies will include investigations and metabolizing functions ' for bio logic d systms by means of radioactive and stable isotopes md cooperative projects on iodine mstabolism, cobalt metabolism and arsenic poisoning, The Office of

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Naval Research i s supporting this group tothe extent of $5,800 for the program i n mass spectrometry. I RECO!dYENDt;TION: It i s recommmdud that the Advisory Conzittee for Biology and k di cine approve that the Office o f Naval Research be notif'icd that funds i n the amounh of Gll,4OO are available for onc year retroactive t 15 January 1948 for the support of research projcct a t Howard University by Dr. Herrmn Branson on BioDr. Louis Ridcnour, University of Illinois :-- This request is for as up of $3,000 t o support, a projcct for the constr&tAon ofa snall radiocobalt applicator t o be used in' the irradiation of various types of snail biologic21 spccincns. Such an applicator could be used i n studying enzyme reactions, in split dose effects on nice and beans and as standard to test consistency RECOX5IdDATION: It i s recopncnded that the Advisory Connittee for, Biology and &dicint? approve that the Office of Naval. Research be notified that funds i n the amount of $3,000 are a vd lib lo for one year beginning April 1 1948 for the support of a research project atthe Gniversity of Illinois under direction of This project is entitled "A Program for Treatmcnt o f Neoplasms 'by the Direct infiltration of Radioactive Heavy Colloids.u Dr.Hahn has r6cently published several articles in which he reports encouraging r csu lts in treating ' various types o f tumors including fibrosarcoma, epidermoid carcinoma and Hodgkin's Disease with direct infiltration of radioactive isotopes. Dr.Hahn ' s

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RECOLLENDATION: It i s recommended that the Advisory Committoe for Biolom and k di cine approve that the Office of Naval Fksearch be notified that funds i n the mount of $50,000 are available for one yecar beginning & $&g 1, 1948 for the support ofa rcsearch projcct Since 1940 there has been i n progress a joint study using radio-isotopes by physicians of the Peter Bent Brigham Hospital ' adthe Harvard Yidical School a d physicists a t the Radioactivity Center of the aassachusctts Institute of Technolo&. made many important contributions on the r o l e of iron, zinc and other metals i n t h e metabolism of hunan erythrocytes and leukocytes and it is also studying tho alterations of these processes i n blood This group has Recent developments emphasize t h e importance of zinc in the white blood cells in relation to leukemia. physicians has requested that the Atomic Enera Conxissicn assme suppo& of their work by allocating $73,650. It was the desire of the Committee that this request be considered during the nonth and be acted upon a t the February meeting ofthe Cormittee. This group of R.ECOiC.G3NDATION: It is rccomendcd that the Advisory Comit tee for Biology and LIedicine approve that th s Office o f Naval Ressarch be notified that funds inthe anaunt o f $4'3,650 arc available for one year beginning July 1, 1948 f c r th2 cmbincd program 2f %rvard University Bedical School and EIassachusetts Institute of Technology and Peter Bent Brigham Hospital on the

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This project desires to study the use of radioactive isotopes in the treatment of various thyroid states. Particular emphasis would be placed on hyper-function of the gland, neoplasms and conditions affecting iodine uptake. ,SECOUMENDATION, It is recommended that the Advisory Committee for Biology and Medicine approve that the Office of . ,. Naval Research be notified that funds in the amount of mare available for one year beg-g April 1, 1948 for the support of researczh projects

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Dr,Uhlruann of this hospital has been investigcting the use of an electron be min 22-rsillion electron volt bctatron, Thcy are anxious t d build a 35-40 n ill isn electronvolt betatron and study the fast electron prorluced by such a nachine, larce research progran on the biophysical approach t o In addition they are interester-! i n a The corrcxpondence from this hospital is encloszd and no re corn a dati on is in lica ted at the present the, This project requests f qG s for support of a progran t o stu6y the WSB of Gamna Ray Emitting R dio active Isotopes i n Colloidal Form as Therapeutic &ent i n RECOX ~ DATI ON : It is recornended that the Advisory app cve that the Office of Naval Research be notified that funds i n the mount of $9,800 are availaldo forme year besinning ,July 1, 1948 f o r the support of a research poj ect at En it ting Radioactive Isotopes i n ColloiZal Fora as Thcrapcutic iiccnt

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This I'equest is for A small grant t o support a problem on t h e\ trans-location of mineral substances i n plants.. This woulc! include i n what tissues they are moved, what the mech-misn of movencnt is, and what relztionship it has t o other physiological processes. Movement would be followed w i t h Geiger counters and would begin Radioactive Isotopes i n Plants11 at institutions incluging Wzshington Studies at present are under way on t h e 'IGvenent of State College, Cornell Univcrsity,Florida Ekperi&ntal Station and University of California, Berkeley.- RECG.SEh3IA'LION: It is re com k led that the Advisory Conrnittec for Biology and k di cine approve that. the Office of Nmal-Research be notified that funds inthe ansunt o f $675 are available f o r one year beginning July I, 19L8 fcm the support of a research project at the Dr. Chmutin i s Pr3fessor of 'Bio-chcxistry atthe University of Virginia and has been engage2 i n 'studies on theI1Distribution and Chernical Changes of Proteins cn the Plasm and Tissues inNom1 and Pathological States in Resoarch kniaals and Hunan Beings." He is a t present working cn research contracts in the Chemical corps of the United State Arqy and frs m the Office of Maval Eresearch.. Dr. Chanutin proposcs a study of the tlPlasna and Tissue Protein Fr act ims " in minds and patients wha havc been exposed, t G varJing doses of radi a tic n for varying periods of tine. The

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work vrculd be carried out or ic in ally on ratst Dr. Stafford Warren a t University of California, Los dngelcs, has a l s o proposed a progran of study on ll?lasna and Protein Fractions A11 available evidence on this progran has not yet It i s recCm+snded that the Adviscry Cor?J;littee for of a research project at University o? Virgiilia Dr. Alfred Chanutin entitled !'Plasma and Tissue of $25,000 are available for one ye%* 3 5. T e + nical Infornation and Publications: k t its last neeting the Advisory Comit tee considered pre lin in ary discussions of the problem of dissemination of scientific in f crat i cn. approved by t h e Atomic Energy Comdssion: Ie 7. Tho use of Radioactive %tc rials fitr Xi lita ry Purposes: The Atonic Energy Corrnission has rcccntly been inforned of a Iprojected prop an as a collzboration bo,tween the %vision g f Ixlitary Application and the &.visi& of Bidou and hkdicine, has recently bcen considered and discussed by the General Advisory 1It i s desired that the Advisory Committee for Biology and %dicine consider this progran and subnit such renarks or,

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The research problems t o be undertaken by the fellarra would involver A. 4tudy of biological effecta of radiation RECoMUMDATIOH: It is recommended that; the Advisory Committee for Biology and Medicine approve the granting of funds t o the Marine Biol~gical Laboratory up t o -?or mmmr fellmahips in Badiobiologg and incidental. expenses, for the summer of 19L8,

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Letter from D r . Cccil Ylatson Industrial He dt had Safety Report of the Advisory Cormittee for Bidcgy and k dic in etc discuss certain phases cf the progrcm. If it i s possible such a pericd