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ADVISORY COW IT TEE FOR BIOLOGY AND MEDICINE UNNERSITY OF CALEORNIA, L.B. CALIFORNIA INSTITUTE OF TECHNOLOGY
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Advisory Committee for Biology ti Medicine The twentieth .-@eting of the Advisory Committee f o r Biology and Medicine ”was‘“”ahe1 on Friday and Saturday, January 13 and 14, 1 9 9 at the University of California, a t Los Angeles, and the California Institute of Technology a t Pasadena, with all members being present. AEC and t h e Division of Biologg & Medicine Dr. Shields marren
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FRIDAY, JANUARY 13, 1950 - MORNING SESSION The vu'ious research projects at the California Institute of Technology were inspected, which included studies on t h e Biological Synthesis of Proteins with use of Isotopes under the direction of Dr. Henry Borsook; the Genetic and Cytological Effects of High Energy Radiation divided as follows: neurospora crassa; Work on the fruit fly drosophila Work on t h e mold melanogaster; Work on India Corn, Zea Mays under the direction of D r . George Beadle. Reports will be studied from time t o time t o determine the progress that is being made i n these
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The facilities at the AEC Project at the University of California were inspected on Friday zfternoon. Committee was interest e d-. in visiting the va-ious laSoratories which included R-fogy, Pharmacology, Toxicology, Biochemistry and Indus tria Hygiene. Minutes of Meeting of November 11 & 12, 1949; order of business presented tothe Committee by the Chairman was a discussion of the minutes of the meeting held a t Oak Ridge Operations Office on November 11 and 1 2 , motion by Dr. Wemn uld seconded by Dr. Hastings. Report on Support of Research Projects. and Dr. Paul Pearson reported that the following projects had been spproved for support by the Division of Biology The minutes were unanimously approved after A and Medicine during t h e months of November and Decenber llA Study of the Redistribution of Bivalent . Metallic Ions i n Bone Metabolism and in Bone Disease m d Neoplasms through the Use of Radio-
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the Norma a d Abnormal Optic Lens” - $12,960 ( 3 ) Harvard Medical School m d Massachusetts Neutrons and Other Radietionstl (4) S t a t e University of Iowa - Dr. Titus C. Evms Mcrphologic Study of Radiation Induccd
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Y5tudies of Vascular Factors i n X?.diation H2morrhege and Other Hemorrhzgic Diatheses i n Mis cell me ous 1I50 (f,pprovd of transfer to mc of ONR contrpct and renewal for one, ysar) Effect of Nutritional Deficiencies inthe Synthesis of Phospholipids ,and Nucleoproteins Brausr - %tudies of Liver Physiology and Pathology Involving tho Use of Bromsulphthalein
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Fungicides i n Dzttxmining tho 2iech2nics of (2) University of Wyoming - Dr. Irene Rosenfeld; Sulfur, Phosphorus and Cplcium i n Selenium Poisoning and t h e Eechmism of Selenium 4th Study of the Ph;ysiclogy of Coldwater li is cd lm eo us 200
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"Use of Radioactive Iodine i n Developing Quantitative Assay Method for Thyrotropic Chloride and Xemopoietic Physiology of Rodents" - of Adsorption and Lssimilzticn of Radioective Use of Isotopes in the Study of the Etiology cf Moore - ''Intracellular Changes i n Trauma, Depletion and Repair; Biochemical Studies i n t h e Human Being with tha Aid of Isotcpest1 -
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Proposals Declined during Novenbcr m d ljeccniber 1949 -c* ___ with Labeled Dichlorophenoxyaco t i c Acid" "The Effects, Upon Livor Function, PrGtein m d F is tula in the'presence of Cirrhosis of the Columbia University - Radiological Research Thyroid Cancer Patients Receiving Repeated Large Doses of REdioactive Iodine t o Determine the Effects of Repeated Vhcle Body Doses of Ir radi st ionqf Illinois Institute of Technolcgy - Dr. Stanley of Lathal h!utatiGns i n Droscphiliefl Loyola University School of Cedicine - D r . Mczrtin Healing of Expcrimentzl \Jmnds'' Wzde Vol n iller - "Effect of Radioective Gold on the Course m d Counteracting Radiztion Syndromeff Tracerlab - Wadiation Bkologyfl fiConstruction of Laboratory f o r Sigh Voltage
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UCLA University of C ili for nie,L.A. presented 2. brisf description of t kcr g mix ation of the JEC project at UCLA. It was of interest to the Cormittee to learn of the studias that are being c,zrriod fonvard a d are prim ril y focus& on: (1) The nechmism .involving the absorption of 2ust particles ad tha effk ' c t ' m 4 @ al ve ol u : surface of the lungs; (2) Study of the toxic effects following tissue irradiation ; (3) Study of mechanism by which materials are deposited in bone and other tissues; ( b ) Study of bone marrow and hemopoietic system and what can be done t o reduce'injury t o hemopoietic Dr, Stafford 17,arren discassed matters of defense regarding the hmdling of large groups of casualties in the event of disaster. In this connection, the Committee was &,pressed particularly with the Alpha Sc in till2tion Counter for Hedth Physics uld Dust Study Applications which had been developed 2t the project under the direction of Dr. Benedict Cassen. This counter hzs many uses. It was of interest to the Committee to learn that a lxx d ve teru ls ' ho spit d has set ?side six beds for the study of the counter qplic & - cn. D r . Staffor-d Warren presented the problem of the
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N myl sint anti on to sink the lfIndependencen. It w.x u n ; m i ? ously agreed that it would bs well t o explore the feasibility of b aach hg the "Independence", the last ship which is still contminated with long-term radiation hazards rather th m sink it. It would then be possible for the ship t o be used 2s2trA ning school, The Director of the ” h v $ sion of Biology 2nd Uadicine proposes t o submit this problem tothe Military Lipison Committee for their considerstion and rscommendations. Waste Disposal Waste Dispos‘d. Dr. William F. Bale reviewed his report on Hedth Protection i n the Hrrndling and Disposd of Radioactive Ystes ” , After afull discussion it was the sense of the Connittee that this excellent report should be published and be widely distributed, Noninoes f o r ACBM. The Co.mittee considered tho following nominees t o teke .the places of t h e two members (Dr, A. Baird Hastings and Dr. George W. Bedle), who are retiring from the nmbership of the Com?.ittc.e effective Juns 30, 1950. Norninees in biochemistry t o replace Dr, Hastings: Yde University. Noninccs in biology t o replace Dr. Beadle:
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The abzvc list will be sent to the Conmission fcr fron the ABCC were sumerized by the ChC2irms?n. thet it might b e we%? I -i fI a contract could bo given toa University which would 'mdertake to cary out the established programs in Japzn, furnish clinical nen through a contract medium, thus relieving the National Research Council. of the ed n in is t ration of the progrm. lk. Stafford Warren suggested further that the stPff could be knmn 2,s tttrcveling professcrs" and be given a six nonthsf to aye a - t s leave of sbsence fron their mt ivers i ties for assignment in Japan on 2rotating basis. The Committee took the view that even though it may become necessa-y to cu rail some of tho activities of the program, the genetic pat of the progrm should.be continued, In fw the rm ce cf these discussions a meeting isto be held a t the Nztiond. Reseerch Council on Februmy 4, 1950, with the following persons in attend axe,to discuss the future progrm of the Atonic Bomb Casualty Comission in
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Col, Carl Tessaer interest the report by Dr. L. R. Donalclson, of the University of Washington, on t h e Biolcgical Effects of the Bikini-Eniwetok Experiments mdthe pli?ns for the Fellowships. The Deputy Director sumarized the status, of the Felbwship Progr,m, pointing nut the t the National Acadeny of Sciences adthe 3Iational Research Council hac! declined t o continue the ndninistraticn of the entire prcgrm, ulc ! that tho Comissicn md the National Acedony of Sciences had come t o ngraenent th2.t NRC should continue t o administer only i! limited post doctor d progrm where ;the research t o be done would i n sny case necessitate security cleerancc of the Fellcw. Dr, Bowers stated further that the Comission i s of the opinion the tal hit ed prcdoctoral fellowship progrm in which Fellows will not necdssarily be subject t o IfQ" clear ace shculc! be ccntinued and thct such a progrm i s
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being establishGd cn arag i in al bcsis. regretted th6 fact that th s Fellcwship Prc$gr?z is t u be placed on 8 regional basis rz the rth ma npticnzl besis, and in this connecticn, passed the follcwing nc.ti,:;n: !(The Advisory Cc ni it tee for Biolcgy and Yedicino i s gr nti fi edt hz t the Atonic Energy Ccmission has ccntirued a fellowship prc;grm+ I 1.-evenI under the ubjecticnsble restrictions impcsed b y ' the rider to the apprcpriation bill. However, it i s the sense of this Cormittoe and our belief that this prcgran shculd be returned to nat i mal I n reference t o ciearance of individuals working under unclassified research contracts, the Chairman of the Committee read the following letter in part from the Chairman of the Atomic Energy Commission, which summarized the clearance requirements which will be applicable inthe (a) "QII clearances will be required for all personnel associated with unclassified research projects involving an apprecizble chance that restricted data may be discovered. (b)Inthe case of unclassified research projects in-qolving a very small chance that restricted d2ta may be discovered, one individual (normally a principal investigator)will be required t o have a I;Qr1 clear ace, and suitable briefing so that the work can be cz re fully monitored; m d no other personnel security requirements will
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(c) In the case of unclassified resecrch projects involving ul essentially zero chance thst restricted d,n.ta may be discovered, no person ns i security requirexefits will be imposed. Civil -C ivil Defense Psychological Swvey. The Cormittee Psychologic d he,md a. report by MI. R. 0. Niehoff and unaninously recommended that in furthermce of the Civil Defense Program i t would bW%y@,l for the Atomic Energy Commission t o conduct a psychological survey of the opinions of adult english-speaking citizens with regard t o their attitudes and knowledge toward ra diction hazzrds and atomic energy. The program i s t o be administered by the University of Michiga a t an q pro xi mtc cost of $30,000 for the work of the survey. of the Civil Defense Program. Security Resources Board have sent telegrams tathe Governors of d.1 the states advising then t o plan their civil defense progrms, 2nd that Federal Rgencies will cooperate m d lend aid reh ti ve to the train i qg of personnel for the trsatment of casualties and from a Dr. Warren reviewed the current activities It i s proposed th z t training coursos be in it ig ted by the AEC to assist the NSRB i n its civil defense functions. monitoring instructors ad the other for the training of
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instructors in the medicrl r.spxts of & mic wcrfsre. After 2- full discussion of the progrzm the Comiittce reiter etc d their previous views regwding Civil Cefsnse Plmning by reaffirming their action as stated in the minutes of February 1 2 , 1949. of the Committee whethe& it was odvisable t o make smsll D r . Warren requested the Pdvice with research contracts. It was the sense of the Committee that each specific case would have t o be judged on i t s merits 2nd considered Radiation Tolcrencos. Dr. 'Jzrren reported on the suggested levels of to lerm ces. 10 for the worker within the plm t 2nd P. sz fe ty fe ctor of 100 for the large population outside the plmt h,?d boon the problem end i? report will be made 2ta later dzte. Deputy Djrector - Dr. John 2. Bowers. that Dr, John 2. Bowers, Deputy Director of the Division, -- He stpted thatP snfaty factor of Further studg' i s being made of the Deputy Director Dr. Wprren reported was tr msf erring to the University of California e t Berkeley for investigative work as of Feb ru xy 1, ISSO. Dr. Bowers will assume the position of Special Assistmt t0 the Director, effective with the assumption of his work s t
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Ik dic in ee that x r. John A. Derry wcs joining the stirff of the Division of Biology m d Medicine as Executive Officcr The next meeting of the Advisory Cozmi';te:a for Biology znd Medicine is scheduled t o be held i n