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(1) The committee agreed that there l a considera%le urgency i n obtaining (2) -use of the coapetency of t k prIncipa1 investigatms RLOm, as shovn by their &udi€!S to date and by t h e i r p2asning for future atulics, and becaase of the nucleu of trained technical ~ ~ * s o n n e land of breed-hg stocks of mice already t k r e , it waa agreed that expamion of these aturliee should entire program i n one leboratory were considered to be of secondwj inpcrtance. cphe commit- re cm nde d that the facilitfee far handling mice at l y adjusted ao that msults from t5e program c8n be obtairad io a more reasonable (shorter) length of ti=. It I s un&ataod that ths program is designed to obtaln information on matation rates at apectfic loci i n araks at lower dosages (150 r and posaibly 75 r ) than tbse p~evlousLgwad (300, 600 and mutation rates In females; to c m ~ l a t eimadlatlon sensltiPltiy of celll~i n bs increased sna that tbe level of cbntiauing support IX? cm28pondiagthe germ line at different stages in dsv-elopwnt wLth hietologtcal ckssnges in female mice as has beendorie with males; tocot ~ tras teffects of cbronic snd acube im-adfation; and to measure m m l l gecetic dmmge in populations. ~ 8 6tbe recommendation of the comittee that t b expamion here proposed should not curtat1 other progrms elrpported ?JY EX nor hrper the mbr taking of or expamion in ot brf le lda of investigation. necessary to eet bat lng the gemtic effects of exgosure to raciation.
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adeqmte daa relative t o a dosage tkrt?shold, or absence thereof, i n the induction of mntatiom by lanizing md-iations. such Momtation at very Lou dmagf3s pmbnbajl lies tria tk biological utaterialcommonly used, It should be possible to exteiid stuaies to much 1aVeZ doues by using micrO0;rganisse in which such Lzw- ntmbers of individuels Te difficulty in obtaining (h) popalation Genetics: Pndictions af genetic damage in future jpBllv8tiQIzll c e ~ r m n tbs mado solely from measrrrewnts of rates of mutation induction. D i r s c t observations can be made over 8 period of gereratiana in experlme- anlmab, snd the accumbfian of genetic effects studied, Precrrutlcns of radlatian QIV a umber of generatione, usan& a variety of organbarns and a Only bx etcdylng the effects numniber of Ue rent ewrbental conditicna, can it be hoped to find the rank3 of lang t e r m effects to be expected t3xm redlation. There -ma not complete
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agreemnt among committee rnem~xraas to ha^ actively this &gram shotita by AM: can be meted to uncover a number of behmlars differing from those already fomd In Rrosophila, It w a s suggested that nev research program should include studlea of eEecta or generalized characteristics, poislts of mfbrenea obtainable only by direct sbservstione on h m e m , refemact p i n t e could be (I) spontaneous mutation rates, (2) rates of-mutation recognized to be an.enomouB undertaking, 'but, if at 811 feasible, should de a m e the strongeat tnterests of AEC. ~naddition to ext@nal.veprograms by individual lnvestigztara, the need w88 recognlzed .In certain areas for cooperative studies which would along t h s e Unes would differ frm t;be reseai-ch program supprrted cometion ~f pertinent infomation on man vaps i n that no single lnvestlgatm or institution is Ukely to propose rrnrkrtnkiug At; It would require an crrganizational effort t o gaW tb coaperation of a number of inetltutlons and individuals. lche question af fewibillty s b u l d be boked into innned€stely. mutation rates among cells in ti3sw cultme s b u l d be actively pU8Sibflity of debrulning spontaneous and induced Dtscuasions &tb interested persons osd moaest fimnclal