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a-4 mit APPROVAL BEFORE DISPATCH Uaiversity of Worth Carolina Chapel Bill, North Carolina 27514 Your letter of lhy 10 con8 &t &a in terer ting time in regard t o our ~ v nplana t o coaduct & rumef of lac 8. lnrolerurce in lima Southwestern n d i w urh8 proposed becure of earlier 8tudlu(Sdnon .t al., Cut lo, 685 (1968) and in different ethaic group. vherrin the lac tue deficiency appear8 t o be on isotopes inmy uperiuotal ptocedurer appear t o make thir uafearible. However, as one of various project r to nlu clinical UBI of the cuban-13 now being produced at Lor Almom, the noa-r8dio8ctive lmctorrl-13C 611 be ured i n the fnfmt8 and child ran of 8- Indian tribes (Navajor mat likely) in whom the high incidence of di arr hu u y be related to lactue deficiency. Thi8 project ir being dam in collaboration with Dr. Joa Shoop, Head of the SecAlbuquerque, md vlth other doctor8 in the field not yet du ign a ted. present rituatim i. that practice ntru are about t o be at arte dat the Ualvrrrity of NW Mao So the feu i bil it y of w e or adequate qu8atity of production ha8 not yet been li ml tine factor for sa^ time to come. Also, ve have not yet submitted t o the FDA 8 notico of intended wc of thir eubrtmce, ilthougb we have done so for conrfdereble detail of duc rip tion and time delay, the noticrm ara bring evenWe hope that thir test vi11 have the feu ibi liq,re lia bil it7,ad safety which you are al ro evidently reekfng. Perhaps ev mtr ull y we could collaborate with you on 8uch a project m a g tbe Sm Juan Pueblo 1udirru.wtth whom y w already tion Of Nucl eu Bk diCh, mutrtnt Of h dio low, UhiWTSiv Of kV He XiCO r Avail.bil it y of the firul, purified product will probably be 8 Our ercperieace 1. tbat, vhile it takes
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h a 0- arrangemente. Perhapa i n the meawhile .election of petientr mci in vu tig8tion by other YIIu could proceed. uhy the organic qatb8sir of k c t o o e - l a C c8a 01 rhould not be taken up by price) throulh )hprroto Cbd cal Company, vhicb &e t h AW outht for rurplur ~ otopu. It appear. mlilrrly thtt ~ aor o m other spthuu of l3~-l.beled Iocident.lly, them are no reuoru t o more defilriu urket needs. certain athrric group. of which you B T ~vel1 aware. There ir, of courre!, e Ugh probability that i t Vi11 b. found t o be typical io Aprricm Sndiuu. only rtudiro Z bow are thoam of Uelrh e t al. [Arch. Intern. Wd. 120, 261 Irctuedeficierrt .nd of Abate e t al. [h.J. Clin. Nutr. 22, 122 (196911 i n which 14 of 24 South American (Cxuxiur) I n d i a vet. JUt'atolermat (but the blood glucore method did a ot di8tiagui.h then from the milk-tolerant group).