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ADYIIXSTRATION OF CrSf To VOLUNTERS upon tho living c lr cula ti ~ gred cell in man 8nd experimental of tho whole-body counter to this technique. 8V8il8bhat the pro a ent time requires withdrawing multiple rad give a docif curve which i 8 extremely difficult to inter - Since t h e whole-body counter would evidenc8 lndiC8t.S th8t there tri u ed chromium is on the red cell, the whole-body counter should be able t o make 8 determi nation in 100 8econd8 .that atthe preeent time requires a about ten prtleots. Dr. HaUr87 Frledm8n of S l n t r Fe, whose son mold rill be working with us, is trying to Obt8in patients that the Hospital Bed hnd of the In8 Alamom Medic81 Center tory of tho Loa Alar08 Cancer Clinic rill perform the controlling Sbfer, rnd Sidney De Brier t brve agreed to help me with these The Special Studies UboraDrs. Robert Gricr, Paul Lee, Charles
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prtionts without charge. W e rould like to obtain your permission at this tire to we boo p1mS t o label tho cells of two men with chronic with aplastic anemia pro b bly secondary t o carcinoma of the poly cy the rir vera, and 1 PD~Bw it h infectious mononucleosis. In addition to your approval of this study and of the labeling of the norm81 persons mentioned aboro, it is planned t o aecure fram erch person, whether or not he is 8hospital patient, 8 par80nally signed permission (properly witnessed) Bandbook 52 gives tho maximum pormi8sible amount of Cr in the total body as 390 microcuries. "hi6 amount is computed on the brim of oral ingestion r nd the kidney is assumed t o be 8s tagged blood cell.. t o bo mhort after It is Separ8ted from the cell. Tho critical organ in t h i 8 a 8 0 is therefore rho18 body, and it is necessary t o recompute the dosimetry on this b8ris. The life of Crsl in the body 18 reported
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a 71 Ka X-rr7 18 emitted with an energy of 5 Kor. Ten per cent of the timea 320-Kev gaapr rayi8 emitted. The latter ha8 an ef foc tiro absorption cw ff ici on t of 0.35 in the body, 80 the enerq) depo8it ionis 112 Kev per grolu. The total energy per d is in te gr rti on is,therefore, 16 Kev. With thi8 enorgy, the do8e rat. is 0.082 rrad/wk or a t o t a l body burden of 1 cc. initial dose rate of 40 u / rk, which i6rf rct or of 10 below the mrxlmur permiaoible level. of CrS1 in this experiment (13 days), even thia dose rate rill not c out in ue for long. The tot81 integrated dore to infinity rill be only 100 mr, which is still -lees than a single reek's returned to the Group Office with your approval in the event you concur in t h i 8 experiment.