Contract No.at-(40-1)-3734, Appendix "a" and "B"

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UNIVERSITY OF MIAMI For the Contract Period October 15, 1971 through October 14, 1972. 707936 ARTICLE A - I RESEARCH TO BE PERFORMED BY CONTRACTOR The Contractor will continue studtes leading t o an evaluation o f the absorbed dose from d i agnos ti c uses of radi opharmaceuti cal s using the rectilinear scanner and scintillation camera and other appropriate instruments and radioactive materials to(1) determine the volume source response function o f the imaging system, (2) t o reconstruct the response of the imaging system t o the specified 3dimensional distribution of activity representing a clinical situation, (3)to find the imaging system that can detect alterations yet with minimum amounts of activity,(4)to collect biological data such as body distribution and biological turnover rates for the clinical situation, and (5) produce calculations of the absorbed dose t o the proximately 5% of his time or effort to the project. ARTICLE A - I 1 WAYS AND MEANS OF PERFORMANCE ( a ) Items Included i n Total Estimated Cost: Salaries and Wages: Pri nci pal Investigator Empl oyee Benefit s : Supplies and Materials: Radi onucl ides ,radi opharmaceuti cals, and Equipment t o be Purchased o r Fabricated by the Contractor: -a Equipment Estimated t o Cost Less than $1,000: -b Equipment Estimated t o Cost i n Excess o f $1,000: Pub1i cations and Communications:

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(8)Indirect Costs (Fixed a t 55% o f Salaries and (1) Items t o be Contributed by the Contractor: (2) Items t o be Contributed by the Government: None under this paragraph ARTICLE A-111 The total estimated cost of items under A - I 1 (a) above for the contract period stated in this Appendix "A" i s $32,631; the Commission will pay 95% ofthe actual costs o f these iterns incurred during the contract period stated in this Appendix 111 and Article B - XXVII. The estimated AEC Support Cost for the contract period stated in this Appendix "A" i s subject to the provisions of Article

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o r any duly authorized representative there of, iricluding the contracting officer, except for the purpose of deciding an appeal under the article (b) The term "Contracting Officer" means the person executing this contract on 'cenalf of the Government and includes his successors o r any duly authorized representative of any such perscn. (c) Except as otherwise provlded in this contract,the term "subcontracts " includes purchase orders under this contract. (a) ?he Commission shall have the right to inspect,in such manner and atall reasonable times as it deems appropriate,all activities of the Contractor arising in the course of its undertakings under this (b) The Contractor shall make progress and other reports in such manner and at such times as spec if ded in Article 3-XXI. The Contractor shall also make such other reports to the Commission, with respect to its activities under this contract, as the Commission may reasonably require from time to time. (c) The Contractor agrees to keep records md books of account, I n accordance with generally accepted ac cow t lng principles and practices, and consistent with the requirenients of 303 Circular No. A-21 as constituted on tine effective commencement date of the contract period, covering its costs and expenditures for items incllided under Article A-II(a) of Appendix "A" and which are i n fix-tkerarxe of the research work under this contract.Inthe event a contractor con tri - but ionis listed in Article A - II(b),the Contractor shell mai cta in records adequate t o permit the Commission t o deternine the extent of the contribution. If professional staff members are included w.c?er Article A-II(b), the Contractors hall maintain records on such personnelin accordame with the payroll distribution po ce dure of section (d) The Commission shall at all reasonable times be afforded acces s to the premises and to these books and records and to related correspondence, receipts, vouchers, memoranda, and other data of the Contractor; and the Contractor shall preserve suck books and papers, without additional compensation there for,fora period of three(3) years after completion of this contract.

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(a) Research results obtained dnder tliis contracts hall be made tion except that no €?estrIc:ed Dcta 2s defined in the Atomic G-,ergy Act o f 1954, as amendeb, or ot ner cia ssl fie d in for nation shall be disclosed t o unauthorized persons. Pzblished resclts shai il ndi cate the; the research was supported by the Corn-issicn. A ccpy o f each article subnitted by the Contractor for p lib lln a tim shall be promptly sent to the Commission. The Contractor shcil also inform the CoDmission when the article is published ani furcish six(6) corLes of the article as (b) It i s recognized that during the course ofthe work hereunder, o r subsequent there to,the Contractor, 54;s employees, orits s-ibcontractors, may from time to time desire i;c publish,within the lin it of security requirements, information regarding technical or scientific developments arising in the course of the contract.In order that public d is lo sure of such Information will not adversely affect the patent interest of the Commissioc, suck icforrnstlon shall be withheld from public d is lo sure if it disc lcs es en invention or discovery which shall be promptly reported to the Conmission, and I n such case, It shall be withheld for a period of four (4) months after submission of the information tothe Commission for gaten; review and possible patent application,unless the Comiission approves earlier release. If so indicated ir. the a rtl cle entitled " A iterations " of 55s contract,the fo1lowir.g sectence shall 'ce deemed t o govern in lieu of the last sentence of Article E-111: "13 order thti: pub ll z disclosure of such infomation mission,Patent approvai for releases hall be secured fron the Commission prior to any such p:iblication." (a) It i s mutually expected that, the act iv it Les under tkLz contract will not involve Restricted Data r,r other c less if i ed information o r material. It i s understood, however, that if in the opinion o f either party this expectation changes > r ix to the expiration or termination of all ac%vi ties under this con;?act, said party shall notify the other party accordingly i n writifig vith out delay. the Contractors hall classify,safe g Jard, and &herwise act with respect to all Restricted Data and other c less if i ed inlormation and material, i n accordance with applicable law and the requirener:ts o f the Commission, and shall promptly ?_?,formt h e Commission ICw rit lng i f and when Restricted Data or other class if led lc formation or Date rial

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becomes involved. If and wheri Restricted Data or other classified in - formation or mate rfd becomes involved, or in the srutual judgment o f the parties it appears likely that Restricted Data or other classified information o r material may become involved, the Co c tractors hall have the right to terni nate performance of the work under this contract and i n such event the provisions of t'iis :ontract respecting termination for the convenience of the Goverment shall apply. (b) The Contractors hall ntit permit any individual to have access to Restricted Data, or other classified infomation, except i n accordance with the Atomic Znergy Act of 1954, as axended, and the Commission's regulations or requirements. (c) The term " 3e strict ed Data" as used in this article means all data concerning the design, manufacture, or utilization of atomic weapons, the productiori of special nuclear material or the use of special nuclear material inthe production of energy, but shall not include data declassified or removed from the Restricted Data category pursuant to section 142 of the Atomic Energy Act of 1954, as amended. (a) The Contractor is solely responsible for the conduct of the (b)In instances where the carrying out of the contract work involves a Commission license,the provisions of the pertinent license shall prevail over any inconsistent provisions of this contract. The Contractor agrees that,, =less the Commission shall give its prior written approval, the Contractor s hdl not use any of the funds provided bythe Commission mder this contract to pay the stipend of any appointment for which commensurate services are not rendered under this contractor to pay any part of the stipend of a fellowship of any (a) The Contractor hereby grants to the Government a royalty - free, nonexclusive, irrevocable license to reproduce, translate, publish, use and dispose of, and to authorize others to do so, all copyright able material produced or composed or delivered to the Gove ment orits designees under this coctrac'i, including vork not first produced o r composed by the Contractor in the Touse of perforn.mce under this contract but incorporated in the material produced or composed o r delivered under this contract(but only to the extent that the Contractor now has,or prior to final szttlernent of the contract may have, the

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right to grant such license to such previously produced o r composed work without becoming liable to pay cozFensatio2 to others solely became of such grant). (b) The Contractor agrees that, except as the Commission may otherwise specifically authorize in writing, the Cc n tractor will not include in any report or other material delivered x der this contract, orin any published material re1a;ing tothe work under this contract, any copyrighted materlal owned by others which such owners have not consented t o have s o iricluded. (c) The Commission will not publish in advance of the Contractor ' s publication without prior con suit ation with the Contractor. (a) Ihenevei- any invention or discovery is made o r conceived by the Contractor orits employees i?. tke course of o r under this contract, the Contractor shall promptly furnish the Commission with comr;lete i n - formation tnereon; ar,d the Sorrmlssion shall have the sole power t o determine whether or not and where apa cent applications hall be filed, and t o determine the disposition of tiie title to as d rights I n and t o any invention o r discovery and my patent application or pacent that majr result, The judgxect ofthe Commission on these zat ter s shall be accepted as final ; and the Contract Qr,for itself and for its employees, agrees that the invefitor or inventors will execate all doc ment s and do all C,hings Eecessary cr proper to carryout the jude ent of the (b) No c la in for pecuniary e.wsrd o r com3ensation under the provisions of the Atonic Energy Ar)t sf 1954, as amended, shall be asserted 3y the Contractor or it seq lo yee s with respect to any invention or discovery made or conceived i n the ccwse of or m der this contract. (c) Except as ot3emi seau thc rize d in writing by the Commission, the Contractor will obtain pater - t agreexents io effectuate t ne purposes o f paragraphs (a) and (b)of this article fr on all Fersons who .serf om aqy part of the work urider this contraot,, except such clerical and manual labor personnel as will not have ciccess to technical data. (d) Except as otherwise authorized in writing by the Comrr,ission, the Contractor will insert in all subcontracts and purckase orders, other than purchase orders for standard co mercia i items, prc visions making this article a2p ii cable to the subcontractor purchase order. Except as otherwlse authorized in writing by che Commission, the Contractor will insert in purchase orders for standarci i.orriiiercial items a provision indemnifying the Government a gal n st liability for use o f any invention o r disccvery and for the infringement of any Letters

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Patent arising by reason ofthe purchase, use,or disposal by orfor the account ofthe Government of items manufactured o r supplied under the purchase order. (e) With respect to any U . S. Pa test Application filed by the Contractor on any contract invention or discovery made o r conceived i n the course o f the contract,the Contractor will incorporate in the first paragraph of the U. S. Patent App li cat ioc the following statement: "The invention described here in was made inthe course of, o r under, a contract(if desired, nay substitute contract with (a) Except as otherwise provided in this paragraph (a) and paragraph (b) of this Article B-IX, title to all materials,supplies, and equipment purchased o r otherwise acquired by the Contractor in the performance of its research activities shall be and remain inthe Contractor. Said materials,supplies,aid equip ents hall be used for the benefit of research under this contract and any extensions or succes s or contracts here to : And, provided, There i s no interference with said research,shall be made available for use by investigators working on any FederaL research agreement at the same location. these priorities,the materials,supplies, and equipment may be used as the Contractor wishes. Except as othe-wise agreed in writing,title to m y items of property listed as "Government property'' shall pass directly tothe Government; such property shall be subject to paragraphs (b), (b) SubJect tothe mutual agreemect ofthe Commission and the Contractor,the Government may furnish the Contractor items of equipment, materials,supplies,or facilities fc r use by the Contractor i n the performance of the contract work; title to these items shall remain inthe Government ur less otherwise agreed it writing. of property and the items of property listed else-vhere in this contract as Government property are here in after referred tc as "Government incorporation or attachment there of to any property not owned by the Government nor shall any such property,or wy part there of, be o r become a fixture or lose its identity as personal ty by reasor; of af fixation to any reel ty. Title to Government property shall not be affected by the IC) To the extent practicable,the Contractor shall cause all items o f Government property to be suitably marked wit3 an identifying mark or symbol indic at is g that the ltems are the property of the Government. The Contractor shall maintain at a l l times and i n a manner satisfactory to the Comrnisslon records showing the use and disposition of

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Government property. Szch records shall be subJect to Commission inspection at all re a sox ble times and the Commission shall at all reasonabie times have access to the premises wherein any items o f Government property are located. Unless otherwise authorized in erty only for the purposes of this contract : Provided, however, That the Contractor i s hereby aut kori zed to use items o f equipment const i - tu ting Governmellt property f Gr other Federal research agreemeflts t o the extent such m e (1) does not b ter fer e with its work under this cm tract,(2)is not prohibited by provisions of the other Federal agreements, and (3)is Frs n ply reported by the Contractor to the …