University of Oklahoma Medical Center Apprndix a (Special Research Support Agreement Apprndix B) (Contract No at-40-1-3578) (for Period Nov 1, 1967 Through Oct 31, 1968)

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UNIVERSITY OF OKWIOMA MEDICAL CENTER CONTRACT NO. AT- (40-1)-3578 For the Contract Period November 1, 1967, through October 31, 1968. RESEARCH TO BE PERFORMED BY CONTRACTOR The Contractor will continue studies of the action of ionizing radiation on permeability and the enzyme systems in skin, particularly with respect to the permeability of the skin to various chemicals, the relationships of the enzymes to this permeability, and the modification of permeability by injury, especially radiation injury. thermal burns and X-irradiation as they influence permeability of ferritin, silver, dextran, etc. skin will be studied histologically, and by staining and biochemical and histochemical methods. Work will continue on studies of A-I1 WAYS AND MEANS OF PERFOFMANCE (a) Items Included in Total Estimated Cost: (1) Salaries and Wages: Chemicals and Reagents Medical Illustrations, Duplication, Etc. Maintenance Contract on Electron Microscope PreDaration of Light Microscopic Slides (6) Indirect Costs (20% of direct costs to AEC. $16,667):

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UNIVERSITY OF OKLAHOMA MEDICAL CENTER CONTRACT NO. AT- (bo-1 1-3578 (b) Items Sinnificant to the Performance of this Contract, but Excluded from Computation of Total Cost and from Consideration in ProDortioning Costs: A-I11 The total estimated project cost of A-I1 (a) above for the contract period stated above is $28,297.00.

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SPECIAL RESEARCE SUPPOET AGREDZXJ" (a) The term "Commission" means the United States Atamic Energy Commission o r any duly euthorized representative there of, including the Contracting Officer, except for the purpose of deciding an appeal under (b) The term " contracting Officer " Iceans the person executing this contract on behalf of the Government and icc lude s his successors o r any duly authorized representative of any such person. (c) Except as otherwise provided in this contract,the term subcontracts'' includes purchase orders under this contract .I t ARTICLE B - I 1 - INSPECTIOB, REPORTS, RECORCS ACD ACCOUNTS (a) The Commission shall have the right to inspect,in such manner and at all reasonable times as it deems appropriate, all activities of the Contractor arising in the course of its undertakings under this contract. (b) The Contractor shall make progress and other reports in such manner and at such times as specified in Article B-XXI. The Contractor shall also make such other reports to the Commission, with respect toits activities under this contract, as the Commission may reasonably require from time t o time. (c) The Contractor agrees to keep records and books of account, i n accordance with generally accepted accounting principles and practices, covering its costs and expenditures for items included under Article A - I 1 (a) of Appendix "A" and which are in furtherance of the research work under this contract.Inthe event a contractor contribution is excluded shall maintain records adequate t o permit the AEC to determine whether the commitment has been fulfilled to the extent necessary; if the principal investigator or other professional research staff are listed under Article A-I1 (b),the Contractor shall maintain tine or effort records i n support of the costs of such personnel tothe same extent as i f such personnel were (a) The Commission shall at all reasonable tines be afforded access tothe premises and to these books and records arrd to related correspondence, receipts, vouchers, memoranda, and other data of the Contractor; and the Contractcr shall preserve such books ar,d papers, without additional compensation there for,for a period of three (3) years after completion of this contract.

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_ _ -,dj+ o r ~ the yc lassi fled in for nations hall be disclose ? t o u2a,u..ci;orsic^. ?:le Cx5r act cr ShC i also ic for n the Commissios when the er tic le Seves (7) copies of each article submitted (b) It i s recognize? $ha: during the course of the work hereunder t3rs nay from time t o time desir ? top blis h,within the limit of security Comission, such information shail 5e withheld from public disclosure if it discloses ar. inventior, o r discovery which shall be pr mp t ly reported ts :?-e Comnissicn, and ir, such case, it shall be withheld fcr a 2eriod cf fcxr (4) months after submission of the information tothe Comission for s a tent review and goss i ble pa2ent application, mless the Comission ..In order that public disclosure If so indicate C in the article entitled "Alterations" of this ccnzract, the following sentence shall be deemed t o govern in lieu of " In order that public disclosure of such infomation will sot ah-erneljr affect the ge:er.t interest of the Comnissior., az tent approval for releases hall be secured from the Com is sio t (a) It i s mutually expected that the activities under this contrac: will rot involve Restricted Data or other classified infomation :r csterial. It i s understood, howevtr, that if in the opinion of ze rz is ation of a X activities under this contract,said party shall eT;er,;, the Contractor shall c lz s s if ya safeguard, an6 other vise act vit k respect to all Fe strict et2ata end other classified in for x at ioc uld = ate rial,in accordance with agpl i cable law and the require n ents ;f :he C miss ioc, and shall promptly inforri the Comission in writing if and when Restricted Data or ct ker classified information o r material

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becomes invoLved. If and when 3e strict ei Data or other classified information or material becomes involved, or in the nut u al judgment of tke Farties it appears likely that SesTricted Data or other classified ir.formation ornate rial may tezome invclvea, the Contractors hail have the right tc terminate performance of the work under this contract and i n such event the provisions of this contract respecting r;eArmination for the convenien:e ofthe Government shall (bj The Contractor shall not permit any individual to have access to Restricted Data, or other classified information, except i n ac:ordance with the Atomic Energy Act of 1954, as amended, and the Commission's regulations or requirements. (c) The term " Restricted Data" as used in this article means all data concerning the design, manufacture, or utilization of atomic weapons, the production of special nuclear material, orthe use of special nunlear material inthe production of energy, but shall not include data declassified or removed from the Restricted Data category pursuant t o Section 142 of t h e Atomic Energy Act of 1954, as amended. ARTICLE B-V - RESPONSIBILITY FOR TEE WORK (a) The Contractor is solely responsible for the conduct of (b) In instances where the carrying out of the contract work involves a Commission license,the provisions of the pertinent license shall prevail over any inconsistent provisions of this contract. The Contractor agrees that, unless the Commission shall give its prior written approval, the Contractor shall not use any of the funds provided by the Commission under this contract to pay the stipend of any appointment for which commensurate services are not rendered under this contractor to pay any part of the stipend of a fellowship of any kind. (a) The Contractor hereby grants to the Government a royaltyfree, nonexclusive, irrevocable license to reproduce, translate, publish, use and dispose of, and to authorize others to do so, all copyrightable material produced o r composed o r delivered tothe Government orits designees under this contract, including work not first produced o r composed by the Coctractor inthe course of

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performance unaer this contract but InccrpcraTsf ii l the material of the contrsc; may have, the right tc gray: a:::-:ccise t o six:. previously Frzduced o r composed work wi:nzi;'- cec x in q ;iable t c pay compensatioc 'co others so i ely becaiiae cr' s - x k grazrt). (b) The Contractor agrees that,excep as tile Commissicn may otherwise specifically authorize in writing,the Contractor will not include i n any report or other material delivered under this contract, orin any published material relating to the work under this contract, any copyrighted material owned by others wkicka such owners have nat consented t o Mve s o included. (c) The Commission will not publish ir, advasce of the Contractor's publication vith out prior consultation vith the Contractor. (a)hh never any invention o r discovery i s made o r conceived by the Contractor o r its employees inthe course of o r under this contract,the Contractor shall promptly furnish the Commission with complete information there on ; and the Com is s ioc shall have the sole power t o determine whether o r not an2 where a patent applications hall be filed, and t o determine the di sposi tic n of the title to md rights i n and t o a.??y invention o r discovery and my patent application or patent that nay resdt. The judgment of the Zomissior? on tnese matters shal; be accepted as final ; and the Contractor, for itself and fc r its employees, 6grees that the inventor o r inver.tors will execute all documents and do all things necessary o r proper to carry out the Judgment of t h e Commission. (b) iLG c la in for pecuniary award o r compensation under the provisions of the Atomic Energy Act of 19%, as mended, shall 3e asserted by the Contractor orits employees with respect t o any invention o r discovery made o r conceived inthe course of o r under this contract. (c) Except as otherwise authorized in writing by the Comission, the contractor will obtain patent agreements tc effectuate the purposes o f paragraphs (e) and (b) of this article from all persons who perform any part of the work under this contract, except such cleric a i and manual labor personnel as will not have access to technical data. (d) Except as otherwise authorized in writing by the Commission, the Contractor will insert in all subcontracts and purchase orders other than purchase orders for standard commercial items, provisions

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making this 2yZiC-P apgli - able to the subcontract s r 3:crzhsse order. a provision in cem if ying the Coverment a gz in st -Iilility for use o f Pazem arising cy reason 2f the purchase, use,ordis7osa lSy or for the account of the Goverment of items manufactured o r supolied under the purchase order. Contractor on any contract invention o r discovery made o r conceived in the c mrs e of the contract,the Contractor will incorporate I n the first paragraph of the LJ. S. Patent Appiication the fcllowing "The invention described here in was made inthe course (a) Except as otherwise provided in this paragraph (a) and paragrapn (b) of this Article B-IX, title to all materials, supplies, and equipment purchased o r othe-mise acquired 5y the contractor in the performance of its research activities shall be and rexrain inthe Contractor.Said materials, supplies, and equipnent snail be used for th s benefit of research under this contract and an:; extensions o r successor contracts here to and, provided there is no interference with said research, shall be made available for use by inveszigators working on a?y Federal research agreement atthe sane location. these priorities,the materials, supplies, and equigzent nay be used as t h t Contractor wishes. t c any Items of property listed as "Government Droperty" shall pass directly to the Government; such 2roperty ska2 be subject t o paragraphs txcept as otherwise agreed in kT it i cg,title (b) Subject tothe mutual agreement of the Comission and tne Contractor, the Government may furnish the Contractor itens of equipment, materials, sr;r;pliea, or facilities for use by the Contractor i n the performance C ft ne contract work; ti tie to these it ens shall remain inthe Government unless otherwise agreed in writing. property and the items of property listed elsewhere ic this contract as Government property are here in after referred to as "Government property.'' Title to Go-Jernment property shall not be affected 'cy the incorporation o r attachment there of to any property not owned 3y the Governnent nor shall any such property,or an7 part there of, be o r becone a fixture or lose its identity as personalty by reason of af fixation to any Such items of

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(c)Tc tte extent practicable,the Contractcr shall cause all items a f Government property tc 're suitably zar kei Yith an identifying nark or symbol indicating that t ke items are the Droperty of the Government. Tce Contractor shzll maintair, at el, ZLmes arid ina manner satisfactory tc the Comlsslon records s'rcwir,g the use and disposition of Government property. Such re cards shall be subject t a Commission inspection atall reasonable t2es and the Cormission shall at all reasonable tines have access tothe premises wherein any items of Government property e relocated. Unless otherwise authorized in writing by the Commission, the Contractor shall use Government property only for the purposes of this contract ; provided, however, that the Contractor i s hereby authorized to use items of equipment constituting Government property for other Federal research agreements to the extent such use (1)does not interfere with its work under this contract,(2)is not prohibited by provisions of the other Federal agreements, and (3) is promptly reported by the Contractor to the Commission under this cc n tract. (d) The Contractor shall promptly notify the Comission of any loss or destruction of o r damage t o Government property. stood that the Contractor shall not be liable for any such loss, destruction,or damage, unless same results from wilful misconduct or lack of good faith on the part of any corporate officer of the Contractor,or of one o r more of the Contractor ' s representatives having supervision or direction of all or substantially all of the activities under this contract. destruction,or damage, it shall promptly account there for to the satisfaction of the Commissior.; ifthe Contractor i s not liable therefor, and i s indemnified, reimbursed, o r otherwise cornpensated for such loss, destruction,or damage, it shall promptly azccunt there for to the satisfaction of the Commissloo. If the Contractor is liable for any such loss, (e) With the written apgroval of the Commission, the Contractor may sell,transfer,or otherwise dispose of items of Ccverment property t o such p a - ties and upon such terns as so approved, or itself acquire t i t l e t o items of Government property upon such terms as may be mutually agreed upon in writing by the Contractor and the Comission. proceeds of any such disposition, and any agreed price of any such Contractor acquisition,shall be paid by the Contractor tothe Government, or credited on account of Commission paylcents t o be made under this contract, as tne Commission may direct. of this contract,the Contractor shall deliver Government property t o the Commission upon request (suitably packed and shipped atthe GovernSubject to the other provisions (f) The Contractor shall utilize for the benefit of the work under this contract such items o f property available tothe Contractor by

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is in the jest interest of the Zo-JerxneCt. Temin z tion of wclrk nereTermination specif;ring tne exten2 TO wkick …