Appendix "a" and "B" - Contract No. at-(40-1)-2681

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UNIVERSITY OF ARKANSAS For the Contract Period February 1, 1963 through January 31, 1964. A - I RESEARCH TO BE PERFORMED BY CONTRACTOR The Contractor will continue to conduct research on whole body determinations of radioisotope burdens i n humans and animals. This work will include utilization of whole-body counting techniques to(1) survey the isotope burden of normal children and adults and of pregnant women before and after delivery, (2) atudy turnover of Iodine-131 i n human patients under various conditions, (3) study of the Iodine-131 level in the thyroid tissue of the general population, (4) determine erythrocyte survival o f Chromium-51 labeled red blood cells, (5) study calcium turnover in normal humans and inpatients with osseous disease uaing Calcitsn-47, (6) study of the effect of various hormones on the (23-47 turnover in mice, and (7)study of manganese homeostasis in parakeets using Manganese-54. A - I 1 APPROXIMATE LEVEL OF RESEARCH EFFORT Premises, FacilitiesJ and Materials t o be Furnished by the Contractor t Adequate laboratory space and facilities necessary t o conduct research on whole body determinations of radioisotope burdens la humane and in animals will be available to the project. Equipment available includes scintillation counters to accamodate (1) the entire human being and (2) small animals. The sc in til - la tion facility consists of a steel room, 128 channel analyzer, power supply, detector crystal assembly, visual and auditory control,os cill o a cope,pulse generator, small liquid scintilla tor and other items including the ones listed in A-111 below. A-I11 EQUIPMENT TO BE PURCHASED OR FABRICATED BY CONTRACTOR- Cost 1. Typewriter, Power Supply and Conversion Collimator and Conversion

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Subetantial deviations from the foregoing shall be discussed with and subject to the written approval of the Commission.

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1. The term "Commission" means the United States Atomic Energy Commission or any duly authorized representative there of,including the Contracting Officer except for the purpose of deciding an appeal under the 2 . The term "Contracting Officer " means the person executing this contract on behalf of the Government and includes his successors or any duly authorized representative of any such person. ARTICLE B - I 1 INSPECTION, REPORTS, RECORDS AND ACCOUNTS, AND 1. The Commission shall have the right to inspect,in such manner and at all reasonable times as it deems appropriate,all activities of the Contractor arising in the course of its activities under this contract. 2. The Contractors hall make progress and other reports in such manner and a t such times as specified in Article B-XX. The Contractor shall also make such other reports to the Commission with respect to its activities under this contract, as the Conmission may reasonably require from time t o time. A copy of each article submitted by the Contractor for publication shall be promptly sent to the Commission and the Contractor shall furnish the Commission with are print when the article is published. 3. The Contractor agrees t o keep records and books of account, i n accordance with generally accepted accounting principles and practice r, covering its costs and expenditures for the research work under this contract, 4. The Commission shall at all reasonable times be afforded access to the premises and to these books and records and to related corre - spondence, receipts, vouchers, memoranda, and other data of the Contractor ; and the Contractors hall preserve such books and papers, without additional compensation there for,for a period of three (3) years after completion of 5. Research results obtained under this contracts hall be made available to all through normal and accepted channels except that no

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" restricted data " as defined in the Atomic Energy Act of 1954, or other class if ied informat ion,shall be disclosed to unauthorized Persons. I n order that public disclosure of such information will not adversely affect the patent interest of the Commission, such information shall be withheld from public disclosure if it discloses an invention, which should be promptly reported to the Commission, and i n such case, it shall be withheld for aFer io d of four(4) months after submission of the information tothe Commission for patent review and possible patent application,unless the Commission approves earlier release. Any publications hall indicate that the research was supported by the Commission. ARTICLE B - I 1 1 DISCLOSURE OF INFORMATION 1. It i s mutually expected that the activities under this contract will not involve Restricted Data or other classified information or material. It i s understood, however, that if in the opinion of either party this expectation changes prior to the expiration or termination of all activities under this contract,said party shall notify other party accordingly in writing without delay.In any event,the Contractor shall classify,safeguard, and otherwise act with respect to all Restricted Data and other classified information and material, i n accordance with app lica - ble law and the requirements ofthe Commission, and shall promptly inform the Conmission in writing if and when Restricted Data or other classified information or material becomes involved. I f and when Restricted Data or other classified information or material becomes involved, or inthe mutual judgment of the parties it appears likely that A e strict ed Data or other classified in for nation or taar-erid, :.~a;. 3e:o..ie involved, the Contractor shall have the right to terminate perfornance of the work under this contract and i n such event the provisions of this c oz tra cz res gec ting termination for the 2 . Except as the Commission may authorize in accordance with the Atomic Energy Act of 1954, as amended, the Contractor shall not permit any individual to have access LO Restricted Data until the designated investigating agency shall have made an investigation and report to the Commission on the character,associations, and loyalty of such individual and the Commission shall have determined that permitting such person t o have access to Restricted Data will not endanger the common defense and security.As used in this paragraph the tern "designated investigating agency" means the United States Civil Service Conmiss ion or the Federal Bureau of Investigation, or both, as determined pursuant to the provisions of t h e Atomic Energy Act of 1 9 5 4 , as arilended. 3 . The term " Restricted Data" as used in this Article means all data concerning the design, manufacture or utilization of atomic weapons, the production of special nuclear material, or the use of special nuclear material inthe production of energy, but shall not include data de class i - fied or removed from the Restricted Data category pursuant to Section 142 of the Atomic Energy Act o f 1954, as amended.

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1. The Contractor is solely responsible for the conduct of the 2.Attention is directed to the fact that, among other legal requirements that may be applicable to the conduct of the work, the Contractor will be obliged to satisfy all of the Commission's regulatory requirements (including those pertaining to the obtainment of Commission 1i c ense s1that may be pertinent. The Contractor agrees that, unless the Commission shall give its prior written approval,the Contractor shall not use any of the funds provided by the Commission under this contract to pay the stipend of any appointment for which commensurate services are not rendered under this contractor t o pay any part of the stipend of a fellowship of any kind. 1. The Contractor hereby grants to the Government a royalty - free, nonexclusive, irrevocable license to reproduce, translate,publish, use and dispose of, and to authorize others to do so, all copyrightable material produced o r composed or delivered to the Government orits designees under this contract,including work not first produced or composed by the Contractor in the course of perfornance under this contract but incorporated in the material produced o r composed or delivered under this contract(but only to the extent,that the Contractor now has, or prior to final settlement of the contract may have, the right to grant such license to such previously produced o r composed work without becoming liable to pay compensation t o others solely because of such grant). 2 . The Contractor agrees that, except as the Commission may otherwise specifically authorize in writing,the Contractor will not include in any report or other material delivered under this contract, or i n any published material relating to the work under this contract, any copyrig:lted material owned by others which such owners have not consented t o have fo included. 3. Anything in this Article or otherwise in this contract notvith standing,the Conmission shall have the right to inspect, use, and have used by others, and to publish and have published atits convenience, any written rate rial first produced o r composed under this contract. The Canmission will not publish in advance of the Contractor ' s pub1 i cation without prior consultation with the Contractor.

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1 . Whenever any invention or discovery is made o r conceived by the Contractor or its employees Ln the course of or under this contract, the Contractors hall furnish the Commission with complete information there on ; and the Commission shall have the sole power t o determine whether ornot and where a patent applications hall be filed, and t o determine the disposition of the title to and rights under any application or patent that nay result. The judgment of the Commission on these matters shall be accepted as final ; and the Contractor, for itself and for its employees, agrees that the inventor or inventors will execute all documents and do all things necessary or proper to carryout the judgment of the Commission. 2 . No claim for pecuniary award o r compensation under the provisions of the Atomic Energy Acts of 1946 and 1954 shall be asserted by the Contractor orits employees with respect to any invention or discovery made or conceived in the course of or under this contract. 3. Except as otherwise authorized in writing by the Commission, the Contractor will obtain patent a green ents to effectuate the purpose of paragraphs 1 and 2 of this Article from all persons who perform any part of the work under this contract, except such clerical and manual labor personnel as will not have access to technical data. 4. Except as otherwise authorized in writing by the Commission, the Contractor will insert in ali subcontracts and purchase orders,other than purchase orders for st&nar;rd co mercia1 items, provisions making this article applicable to the subcontract or the purchase order. The Contractor will insert in purchase orders for standard commercial items a provision indemnifying the Government against liability for the use of any invention or discovery and for the infringement of any Letters Patent arising by reason of the purchase, use or disposal by or for the account of the Government of items manufactured or supplied under the purchase order. ARTICLE B-VI11 PROPERTY ITEMS 1. Except as otherwise provided in this paragraph 1 and paragraph 2 of this Article B-VII15 title to all materials, supplies and equipment purchased or otherwise acquired by the Contractor in the per - formance of its research act iv i ries $ hall be and remain in the Contractor. Except as otherwise agreed ir. m - itiri ~ ,t it leto any items of property listed as "Government properej-" shall pass directly to the Government; such property shall be subject to paragraphs 2 , 3, 4 and 5 of this Article B-VIII.

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2.Subject to the mutual agreement of the Commission and the Contractor,the Government may furnish the Contractor items of equipment, materials,supplies.or facilities for use by the Contractor inthe performance of the contract work; title to these items shall remain inthe Government unless otherwise agreed in writing. Such items of property and the items of property listed elsewhere in this contract a s Government property, are here in after referred ' t o as "Government propration or attachment there of to any property not owned by the Government nor shall any such property.or any part there of, be or become a fixture or lost its identity as personal ty by reason of af fixation to any realty. Title to Government property shall not be affected by the incorpo3. To the extent practicable,the Contractor shall cause all items of Government property to be suitably marked with an identifying mark o r symbol indicating thar. the items are the property of the Government. The Contractor shall maintain at all times and ina manner satisfactory to the Commission records showing the use and disposition of Government property, and unless otherwise authorized in writing by the Commission, shall use Government property only for tne purposes of this contract. Such records shall be subject to Commission inspection at all reasonable times and the Commission shall at all reasonable tbes have access to the premises wherein any items of Government property are l o - 4 . The Contractors hall promptly notify the Commission of any loss or destruction of o r darna:;e to Government property. It is understood that the Contractor sha li not be liable for any such loss,destruction, or damage, unless same results fr cm wilful misconduct or lack of good faith on the part of any corpora:e officer of the Conn ? tistx, 3r of one or more of the Contractor ' s representatives having supervision or direction of all or substantially all of the activities under this contract.Ifthe Contractor is liable for any such loss,destruction, or damage, it shall promptly account there for to the satisfaction of the Co mission ; ifthe Contractor i s not liable there for, and i s indemnizied, reh burs ed ; or other - wise compensated for silch loss,destruction, or damage, it shall promptly account there for to the saris faction of the Conmission. 5 , With t ne written approval of the Co mission,the Contractor may sell,transfer or otherwise dispose of items of Government property t o such parties and upon sw:i terms a s so approved, or itself acquire title to items of Governinent- ? roper ty upon such terns a3 may be mutually agreed upon in writing by rhe Contractor and the & mission. The proceeds of any such disposition. and any agreed price of any such Contractor acquisition,shall be paid by the Contractor tothe Goverrnent, or credited on account of Commission payments t o be made under this contract, as the Commission may direct.Subject to the other provisions of this contract, the Contractor shall deliver Government property to the Co mission upon

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ARTICLE B-IX TERMINATION BY GOVERNMENT 1. The period for performance under this contract may b e terminated by the Commission by written notice,either because of the breach by the Contractor of the provisions of this contract or for the convenience of the Government. In the event of such termination,the Contractors hall promptly furnish to the Commission such of the results of the work performed under this contract (and nott heretofore furnished) as the Commission may request. 2 . Upon a termination for convenience hereunder the parties shall agree …