Yearly Report on Allocations of Radioactive and Stable Isotopes

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Oak Ridge, Tennessee AND STABLE ’ I SOTOPES Isotopes Davis ion Oak Ridge Cpe rations z ISOTOPES D IV ISION CIRCULAR Oak Ridge Ope rations United ‘ States Atomic Energy Commission Oak Ridge, ‘ Tennessee

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TABLE OF CONTENTS Yearly Report on Allocations of Radioisotopes Yearly Report on Allocations of Stable Isotopes

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Presented herewith i s the first year's report on the allocations of radioisotopes and stable isotopes covering the period from July I, 1946 t o June 30, 1947. Tine distribution program was inaugurated under the jurisdiction of the Ih hatta n District and the first year of activity was completed after the .iitomic Elslergy Cods sion had assumed control of the project, the Isotopes Branch, Research Division, Field Operations which maintained its identity throughout the entire period.ccvered by the report and which has since become t h e Isotopes Division, Oak Ridge Operations. Continuity was attained through the r o l e played by radioisotopes rere allocated. departments concerned, together with the isotopes requested and a brief statement of the investigations in which the isotopes were t o is presented a detailed list of the individuals t o whom Shown also are the institutions and In Part II stable isotopes vere inade. for radioisotopes in Part I, These lists are not for publication, either in whole or i n part, will be found a list of those t o whom allocations of This list is entirely simiZar t o that

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YEARLY REPORT ON ALWCATIONS OF R.ADIOIsOTOPES The following list shows the imes and locations of the institutions, departments, and users of radioisotopes from whom requests f o r allocations of such materials were received during the period from July 1, 1946 t o June 30, 1947, Shmm also are the radioisotopes requested and a brief statement of the study t o be made with t h e isotopes when allocated. Action on a l l but nine requests hzs been completed, t o refuse only three of the requests, although eight were canceled before final action was taken, Of the 686 t o whom allocations had been made by June 30, only 28 had not been taken up by the requesters. It was necessary This list has been compiled in order t o show in detail how the program of distribution of radio iso to psk s progressed during the first year. The list is not for publication, confidence of tne investigators listed, because: It is necessary t o preserve the ( A ) h y of the studies have not been completed and a r e not ready for publication, and (B) The individuals should not be subjected t o unwarranted solicit at ion,

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Kets York City Piew Yorlc City Pbrmaceut ical Chelaistry Amei,. Smelting & Lefining Sc. Irradiation Service: To stuCy the effect of neutrons on the optical aid physical properties of quartz nate rial in diabetic d - ac.ls. To trace fate of car boh mate I: 131: Thyroid diagnostic and peutic qent in leukemia and ? 32: Testing certain medicinal products t o deteriirine the effect of various substances on the calciumStudy of ? 32 as a therapolymerizction and vulcanization a d of the role of sulfur-bearing Study 02 mechanics of

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Sev; York City Mellon Institute of University of Cdif ornia iy iea polis University of Chicago University of Cali for ~ a University of California University of California Isotope and Purpose logical thyroid Pmction and. of mechanism o l action of anti th moi d and glycine into the tissue proteins Rate 8tudy.of ectry of leucine ation of hydroczrbons from hydrogen anu carbon monoxide over metal To study t h e mechanism of To study mechanism of protein To study exclvnge of bones and teeth uidei. different conditions of age. Study of exchange of C by phorus by bones end teeth .Jilder Varp ing nutritional cofiditions . Study t h e exchmse of phosaspects of photosynthesis. X study of the fundamental inthe body isto be investigated Tile fate cf label ei fats

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122 Shell Development Company 123 University of California I24 Uruversitg of Cdi for nia University of Californit.. Nashville , Temies see Passxic, iielv Jersey Universitr of Chicngo Isotope and Purpose cholanthrene on enzyme system. Study in vitro photodecomposition. Study of action of methylbution of phosphorus ?.n growing and noncat ely tic hydrocarbon Study mechanism of catalytic iron i n experimental anemic To study turnover of tissue proteins, Lietabolism of plasm proteins i n noma1 and li vcr less nninlals. cobalt in the eli zp ii c processes To study rate of tur now r of A study 01 the role of Au 198: jtudy selective local&- syntnetic orgenisms. Study of Study of the inechmism of

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Inst itut ion Hodry Process Corp.of Fern. University of Chic ~ o university of Lichigm Isotope and Purpose active carcinogenic hydrocarbons. neasurenent techniques mdfor study of synthesis of orgdc Ta 182: Nuclear spectroscopic Developiient of detection and Salt Lake City arsenite. i gri cdt ural desecrch Study of absorption through Beltsville , Lcaryland absorbed horrmncs in plants. Div. Biologiaally Active Cpds, Bio c ned st ry Illinois State water Survey Zont ef i cr e Hos pit 01 Bronx, New York in aninals and humans. Study of iron mta bol isn t ation of acetic acid. To trace the rrithme fernen-

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Vser - Isotope and Purpose kr var d Xeaical School C a: Research in intermediary Baston iaetnbolisr:? of such glycogen Biological Lcboratory precui.sors as lactic and pyruvic iJniversity cf Tittsburgh Cu 64% Study its effect on Pittsburgh, Fern yl vd a Biological Sciences genesis. . isolated organ systems in rLiorphoUniversity of Chicago C Id+: Production tagged starch in hatomy cytoplasmic fenotic fcc tors in ParaL. L. Doyle meciun using also the bac teri u Aerobacter 2.s tirzged food source. University of Chicago C 3.4: Chicago ciecarbcxyiation of om l acetic acid Biochemistry t o pyruvic 3ciZ mc! carbon dioxide. TG study reversal of enzymtic Univcr sit y of Ch icqo cilicwo for biological syhthesis of’protcporkdiobiologg ami Biophysics phyrin aoicty of henoglobin. Study the usc of ?.cetic acid Univcr sity of C h i cazo C l.4: Study node of growth of cellulosc v:alJ.s of put cells after Uetcibolic Checiistry acids. Hcrticulture distribution of radiocarbon. induce homcncl effects md to studs Study of entry of labeled CeGms of Lebanon Hospital F 32: To s t k y vasCd2.r capacity Research Iaboratory mil kidney. and dist rih tion in hunrrn heart Ys l low Springs, Ohio Study chlorophyl and photo-

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Cebrs of Lebanon Hospital University of Florida iiashingfi on Unive r s i ty S t amford, Connect icuk New Haven, Corn, &SS. Inst, of Tech, University of Kansas University of Kansas Isotope and Purpose I 131: To study intractable thyroid extract administration ' on calcium distribution, retention, excretion in intact and p&aC u 64: Study of metabolic ' interrelationship between iron, cobalt, phosphorus and copper. Study of effect of paraTreatment of leukemia and F 32: Fundamentel studies on me chtxiism of flotation of sulfur contrrining peptide, glut+ Biological synthesis of t h e radiations, braxhing of K-capture and beta emission vdth view t o Sc 46: Study of t h e radiations, branching of K-capture and beta Ru-Te mixture: Study of ksic. chemistrf of Ru and exchange mong complex co-ordination compounds of Ru; analytical chemistry of Te. Co 60: Study of stability, interconversions and reactions of Study of the

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Stanford University Hospital University of Cclifornia University of Czlifornia University of :E.Ji s consin University of his consin University of iiis consin University of hisconsin Isotope and Purpose as a therapeutic cgent in the treatment of lyrnphoid mlignL?ncg, To study the use of Au 198 in microorganism and carbohydrate chemistpj of colloidal eleckrolytes;. detergents, soqs, wetting activity of Zn compounds i n higher plants as well iis t o iso?,ite the car ying, complex ion f om tion and solvation of ions. To determine the bio logic cl C l.4: Study of the nechvlism of therm.21 and photochemical exchmge reactions; carrying, complexing, complex ion format ion, solvation and of exchmge between oxidized and reduced forms in aqueous carrying , complex ion formation, solvation and inter ionic exchange. Studies of c wry hg,

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of carrying, complex ion f om tion m d solvation of ions. University of blisconsin of read ions initiated by isomeric nuclear trans it ion, Study of the kinetic sUniversity of iii s consin Ca 41, 45: Fundamental studies of carrying complex ion formation and reaction constants of reactions of halcgens with halogenated carrying of anions, complex ion formation, solv,?;tion of ions and inter ionic exchange reactions, University of liisconsin University of liisconsin reaction constants of reactions of halogens vdth hlogcnzted Ag 108, UO: Fundmental studies of carrying, complex ion formt ion University of Uisconsin 179 university of Msconsin John E, ii ill ard ccrrying of anions, complex ion f om tion, solvrztion of ions and inter ionic exchange reactions. Cl36: Kinetics and fundamental recction constmts cf thermal and photochdc?.l reactions of chlorine with halogenated hydrocmbons; exchmge between hclogijns , a d haloger; acid rcd icd s in m.peous solution; ins md solvztion involving acid 181 University of 1. isconsin CO 60: lis 3 g m a rcy standard.University of vrisconsin John E, iri Urd

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Idemor ial Hosp i t a1 - Isotope and Purpose of h b e led compounds. Study of tumor metabolism Strong Lienorid. Hospital I 131: Studies of malignant thyroid Rochester, New York tumors , liestinghouse Res. Lab. Zast Pittsburgh, Perm. carbon in pure iron, during aging, Cornell University ad, Coll, S 35: New York City Mew York City Vincent du Vigneaud New Pork City Tuber culm is Control tissue. Study metabolic paths <and fates of sulfur compounds in Vincent du Vigneaud & A s . Study the metabolisa and t mrisf omct ion of carbon conpounds Biochemistry in vivo. bclisn of bacteria and host Bronx, New York Study and treatnent of thyroid of Ledicine utilization and excretion of iron. Fublicker Industries, Inc. C a: finalytical determination of Philadelphia glycerol in fermentation processes, Navy Licdical ites. Unit #l a c tBrio logy pest is. iiill be used t o Woe1 the port of C02 in pLants will be cnlculcted, Study of t h e rbetabolism of sucrose i n -1s.

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Inst it ut ion Cord tte c on Growth methods of prep ration of combined effects of Fe,& New York City mechanism of the olygoclynmic Investigation of t h eIntcrnztional Rare Metals t h e corrzbined effects of Fc2O3 and of bbta ray emitters in the field of high voltage clectronics, Princeton, New Jersey I 131: Study of th void ,b ss. Genernl Hospital kso, Genercl Hospitnl Rulon lr' izatvs on I 131: Cornpaison of capacity of tumorous adnom1 thyroid t o collect iodine; utilization of iodine zftor us(; of drugs, Co 60: To determine rates of sc tt ling of additivcs in oilto cstimatc s rti clc sizc distribution mci trcatment of thyroid disorclcrs. 201 Gulf Elcs, & Dcvclopmcnt Go, New York City Rochcstcr, Mew York School of Iicdicine P 32: To determine the effcat of P 32 on bone using the chick

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Bio chcmist ry University of iuisconsin New York City Californiz Inst, of Tech. hss, Inst. of Tech. Isotope and Purpose e clampsin . Study of calcium zntigcns of t h e Flexner dysentery org dsm will be Ubeled vith fixation of C02 i n glycogcn and conversion of lowcr fatty acids t o glycogen in rats. I 131: The treatment of Study the mecWism of t h c soft tissuc: phosphorus compounds establish the function of vitamin D, To study thc ro la tion of Johns Hopkins W vers it y E.1. du Pont de Nemours & Co. L.1. du Pont de Piemours & Co. C 14: Study of protein synthesis by 9.nlmzl tissue slices in vitro, by cnzymes in vitro, in rzts, ray sbsorption coefficients in vu io us elements , P 32: Stmdardizction of cosmic ncch?dsm of cction of sulfur modiiicrs i n synthetic pom or s. reactions initiated by betaStudy of new chah

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Inst it u t ion Liurray Hill, New Jersey Bell Telephone Lab. Zurray Hill, New Jersey Harvard dedicnl School Arthur Et. Adamon Bronx, New York Western Res. University Navy Xedical Res. Unit National, Inst, of 3ed.t h Sy ?lalit leaves i n dark an6 light. Stdq of protein synthesis activity of filament5 coated with alkaline earth oxide, activity of f ilanients coated with alkaline earth oxide. tion of hichly water-soluble and 1331: Thc diffusion coefficients of Na md iodide ions in NaI ivill be determined, To trace the-icdination of corqounds related to th pox in e. K 42: Study of pcriodic paralysis, i n vivo on lllusclc cbring and preceding an nrt if ici ally induced attack. I 131: Study of therapeutic effects of I 131 in thyroid. P 32: To label influenza virus and pcsteurella pestis and t o study fate of these org dms in ani.id3. and synthetic aitigens in a niz ds, To trace trrgpd bacterial I 131: St dy of io he absorbinz czpacity of thyroi&s of rats and chicks zfter treatment with mti-

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Los Angeles Tumor Inst .Ias Angeles Chohers rij. Sherwin Rochester, & me sota National Naval Xedical Carncgie Inst, of liash, New York City Isotope and Purpose P 32: Treatrfient of polycythemia. K 42 : Measurement of the rate of K excretion fol lom i intravenous bolism in patients with polycythemia vera and leukemia. Study of hemoglobin netak study of the mornentwn of Treatment of exophthahuc goiter. acids t o study synthesis md action of thyroxine. In vitro studies with amino Development of ' suitable I 131: 'Tracer studies in the thyroid, Therapy of hyperthpoid. and cancer-loc3lizing properties of Sb labeled organic compounds. Ru 106: To treat cmcers in animals.

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Ohio State University Columbia Vnivers ity Mew York City California Research Corp, Variderbilt Xedical School hpiximent al Biology Shrewsbury, ks s a chu sett s College of Yedicine Texas Rd ation and Tmor University of 5 i isconsin Isotope and Purpose P 32: Treatment of polycythemia precursors m d metabolism of C L!+: To study the mechanism of formation of cdrbon deposits on the use of :?u 198 as a therapeutlc agent i n the treatment of lymphoid K 42: To study the physiology and biochemistry of hormones of the cdrenal cortex i n subjects under inhibitors and drugs upon t h e deposition of cystine i n the hair, To study effect of enzyme in vcrious tissues. m d excretion of a drug. determine its distribution in To study rF.te of zbsorption I 131: Study secretion and distribution of radioiodine i n the use of acetic zcid f o rChicago biological synthesis of protoporphyrin i-loiety of hemoglobin.

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Mayo Foundat ion Vanderb ilt Xedi c a l Schoo1 Bronx, New York New York City Beth Israel Hospital Parke, Davis t3 Conpany Ithaca, Kew York Mestinghouse Res, Lab. East Pittsburgh, Fenn. iliass, Inst, of Tech. Isotope and Purpose P 32: The treatment of diseases of the …