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I a Safety Standards. Development of safety standards for the control o f health hazards owing t o contamination o f factory air with 'E, F and otheg todc materials. Ia. Chronic exposures of animals to atmospheres containing various T dusts. F i v e compounds have been selected for stndy, Viz., trations of each compound (and four levels o f one compound if # possible) are t o be carried out fora period o f one year. Acute exposures (30 days) of animals are to be made on a number of compounds at certain levels. These compounds include: ore - tests at 2 levels, 4) those scheduled fcr chronic studies on which insufficient data a r e available to permit the selection of dust concentrations for the chronic exposures, 5) other compounds t o be agreed upon, e,g., TO,, T308, NH4 salt, Na 6 d t , Chronic exposures t o atmospheres containing GZL6 t o be carried -d. Construction o f larger chambers t o replace certain small units, (specifically, No. 1, 9) t o accommodate increase& numbers o f dogs. Engineering control o f the concentration o f the noxious agents inthe chamber air.
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I. -e. Auxiliary Toxlcity Tests. Ingestion experiments on rats t o be completed on schedule; no new rat feeding experiments a r e ill- !Kl$'a, S nitrate and TC1, for one year; other important cont pounds t o be fed dogs for one year as soon as facilities permit. Dog feeding experiments on three compomds, viz., Short term (30 day) feeding experiments on rabbits t o permit mah ation of lung exposure experiments. Tests of the toxicity of compounds applied directly t o the lower respiratory tract, f, Experiments designed to test excretion and storage a8 a function of w u n t of T absorbed, of the form and of the routes of intake, These tests w i l l be made using chemical and isotopic methods. The results will furnish a basis for the evaluation of analyses of industrial urine samples. 11, Protective Devices. Testing of masks and respirators for the use of plant personnel. Only a few tests are anticipated; facilities are 111, Approximate Toxicity Determinations, Tests on new special materials of unknown toxicity. Facilities available. IV. Methods f o r Recognition and Control of Poisoninq. .Iab Mechanism Studies. Three principal topics a r e as followst I) Kidney function in animals exposed toT compounds. 2) T complex formation by various compounds t o promote UriIXaV personnel for collaborative tests m3sisting mdical supervisors. On request, t o Frovide techniques and trained