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ADVISORY COEdITTEE FOR BIOLOGY AND MEDICINE UNIVERSITY OF CALIFORNIA, L.B. CUI FOR NIA INSTITUTE OF TECHNOLOGY
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Advisory Committee f o r Biology RC Medicine The twentieth meeting of the Advisory Committee for Biology and Medicine was held on Friday and Saturday, January 13 and 4, 19% at t h e University of California, a t Los Angeles, and the California Institute of Technology a t Pasadena, with all members being present. Members of Committee Dr. Alan Gregg, Chairman AEC and the Division 1 urs. Frances R. Montgomery
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The vsrious research projects atthe California Institute of Technology were inspected, which included studies on the Biological Synthesis of Proteins with use of Isotopes under the direction of Dr. Henry Borsook; the Genetic and Cytological Effects of High Energy Radiation divided as follows: neurospora crassa; Tork on the fruit fly drosophila melanogaster; Work on I n d i a Corn, Zea Y2ys under the Work on the mold direction of D r . George Beadle. Reports will be studied from time t o time t o determine the progress t h a t is being made in these gene tic studies .
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The f z c ili ties at the 1,EC Project atthe University of'California were inspected on Friday afternoon. Committee was interested in visiting the various laboretories which included Rzdiobiology, Pharmacology, Toxicology, Biochemistry and In dust rid Hygiene. Minutes of Meeting of November 11 L 12, 19119. order of business presented t o the Committee by the Chairman was a discussion of the minutes of the meeting held a t Oak Ridge Operations Office on November 11 and 1 2 , Report on Support of Research Projects. and Dr. Paul Pearson reported that the following projacts had been approved f o r support by the Division of aiology The minutes were unanimously approved after a and Medicine during the months of November and Decenbor IIA Study of the Redistribution of Bivalent . Metallic Ions i n Bone Metabolism and i n Bone Disease and Neoplasms through the Use of Radioisotopes and Novd Chelating Compounds1t- $8,000
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'rHjstochemical Study of Cement Substmces of the Normal and Abnormal Optic Lens" - $12,960 Harvard Medical School and Massachusetts Neutrons and Other Radietionstf Mcrphologic Study of Radiation Induced DOE Amt gf Es
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Itstudies of Vascular Factors in Radiation H,morrhege and Other Hemorrhzgic Diatheses in 0M iscel lans ous (!.pprovA of transfer to uc o f ONR contrpct Effect of Nutrition21 Deficiencies inthe Synthesis of Phospholipids pad Yuclao?roteins and renewal f o r one year) Brauer - %tudios of Liver Physiology and Pathology Involving the Use of Bromsulphthalein
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Fungicides in Determining t h o Xechanics of University of Wyoming - Dr. Irene Rosenfold; Sulfur, Phcsphorus and Cplcium h Selenium Poisoning and t h e Gdechenism of Selenium "A Study of the physiclcgy of Coldwater
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b. Proposazs extended during November and December 19h9: VJse of Radioactive Iodine in Developfig Quantitative Assay Uothod f o r Thyrotropic Chloride end Xemcpcietic Physiology of Rodents" - cf Adsorpticn and Ls simi b tic n of Radiwctive lrEffccts of Neutrons a d Othar RadietioJs on the Use of Isctopzs in the Study of the Eticlogy of Uooro - 11Intracellular Changes i n Trauma, Deplaticn and Repair; Biochenical Studies i n t h e Hunan Being with tha Aid of Isotcpesfl - (Dura tim September 16, 1949 t o September 15,
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with Labeled Dichlorophenoxyacetic Acid" IIThe Effects Upon Liver Function, Protein ?ad Hemcglobin Uetabolism of Perfcrming cn Eck F is tula in the Presence of Cirrhosis of tho Columbia University - Radiological Research Thyroid Cancer Patients Receiving Repe?.ted L3rge Doses of Radioective Iodina t o Dztemine the Effects of Repeated 7 b ~ l aBody Doses o f Haci ing of Experimznta Ikunds" Ii Eff oct 2f Radioective Gold on the Coursz a d
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University of Californie, L.A. Dr. Stafford Tfarron presenteC 8briaf description of t k orgznization of the AEC project atUCU. It WZS of interest to the Comittce to learn of tha studi ~ st hzt are being carriod forward a d are prim ril y focus ? on: (1) The nechvlism involving the a bso qt ion of dust pc w tic les and tha effect on the alveolar surface of the lungs; (2) Study of ths toxic effects fol lol v kg tissue irradiation; ( 3 ) Study of mechanism by which materials are deposited in bone and other tissues; (L) Study of bone narrow and hemOF9ietiC system and what can be done t o reduce injury t o hemopoietic regarding the haxiling of large groups of casualties i n the event of disaster. In this conmction, tha Comitteo was bq res sad particularly with the Alphp. Sc in till2tion Counter for Hezlth Physics ad.Dust Study Applications which hzd been deveioped 2 t the project under the direction of Dr. Benadict Czssen. This counter hzs many usos. It was of interest to the Comiilttee t o learn th stal ocd - veterans ' ho spit d has set ?side six beds for the study D r . Stafford Warren presented the problem of the
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Nmyfs intention t o sink the nIndependenceIt. It WBS un m hou sly agreed that it would be well t o explore the fa e sibi lit y of baaching the "Indcpendcnccfl, the l-?st ship which is still contain a ted d th long-torn rcdiation hazards rather thm sink it. be possible for the ship t o bo used es a tr rhin g school, The Director of the Division of Biology 2nd LiJzdicSne proposes t o submit this problem tothe Military Lipison Comittee for their consideration and rocommondations. on H e d t h Protection in the Hmdling and Disposd of Rp.dioectiva ,Jc?stesI1, dfter afull discussion it was the sensa of the Cornittee t h a t this excellent report should be published nnd be widely distributed, It would then noninees t c t;.ka the places of the two members (Dr. A. The Cornittee consic'ered tha fol lo xing Noair.~:cs i n biochemistry t o replace Dr, Hastbgs: Noninocs i n biology t o replece Dr. Beadle:
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The abovo list will be sent to the Commission for f r a n the ABCC were sunnzdzed by tho Chzirman. The problens emmating thet it might be well ifa contract could bo given toa University which wouid undsrtake to cary out tho established programs in Japm, furnish clinical nen (including geneticists and physiologists) , and facilities through 2 contract medium, thus relieving tht: Nztional Research Council of the adninistrztion of t h e progrrom, be hewn as f1trz.veling professms" and be given a six fur assignment in Japan on R rot sting basis. mittee took the view that even thmgh it nay becorna necessary to cu rail scme o f the ect iv it is s of the program, ths genetic pat of the progrm shculd. bi? continued, I n fuzthermce cf these discussicns a meeting isto be held at the Nationzl Research Council on FebruFry 4, 1959, with the following perscns i n attendmce, t o discuss the
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Atonic Bmb Casualty Comission Atonic Ensrgy Ccmissfqn Dr ez i lton J intern it a Bikhi - Bikini-Eniwstok Experiments, The Committee henrd with Exp a r irnent s interest the report by Dr. L. R. Donaldson, of the University of Wlashington, on the Bio l cgi cd Effects cf Fellowfihips Fell m ships The Deputy Director sum a rize d the statue o f the Fellciwship Prsgr,m, pointing out thet the Nz tion d Rcadcr.?yo f Sciancos a d the National Reswrch Council hac? declined to c cnt hue the abin is tra tic n of the entire of Sciencas hr?dccxe t o cgraement thet NRC shculd continua to dn in is tsr aly 2. limited post doctor d progrm where the rose ? rch ts be dcne wotlld i n any case necessitete security c1d? rm so of the Fellcw. Dr, Bcwcrs statod further that the Comission is of in which Fe11:ws - N i l 1 nut necussarily be subject t o “Q” clearance shsglc! be cmtinued end thct such a progrpm is
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being established on a regi;n,al bssis. Tha Com.ittoe regretted the fact that the Fellcwship Prog rm is tcr be placed on a regional basis rather th man2tion d basis, and in this connecticn, passed the f oll cw kg nc t ix : - , 1lThe Adviscry Ccxmittee for Biolcgy and Yedicinc i s gratified th z t the Atonic Energy Cc?r.i!ission has ccntirlued a fellowship prcgrm, even undar the ub jecticnablo restrict i uns imposad by the rider to the apprcpriaticnI ,. .. bill. However, it is the sense of this Cornittoe and our bulief that this prcgraa shLuld bi: returned to na tic nal 'In reference t o clearance of individuals working under unclassified research contracts, the Chairman of t h e Committee read the following letter in part from the Chairman of the Atomic Er,ergy Commission, which summarized the clearance requirements which will be applicable in the (a) ?lQT1clearances will be required for all personnel associated with unclassified research projects involving an apprecinble chance that restricted data may be discovered. I n the case of unclassified research projects bwolving a very small chance that restricted data may be discovered, one individual (normally a principal investigator)will be required t o h2ve a ':Q11 clear ace, and suitable briefing so that the work can be c me fully monitored; and no other personnel security requirements will
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( c ) I n the case of unclassified resepxch projects involving 831 essentially zero chance that - restricted dzta mey be discovered, no persormel security require m nts will be imposed. Civil Defense Psychological Survey. The Committee heard a report by Mr. €4, 0. Niehoff and unaniaously recommended that in fhrtherance of the Civil Defense Progrvn it would be well for the Atomic Energy Commission t o conduct a psychological survey of the opinions of adult english-speaking citizens with regard to their attitudes and knowledge toward radiation hz z ads and atomic energy. The program is t o be administered by the Univarsity of Michigm at an qproxknztz c o s t of .#3O,OOO for tha work of tho survey. Civil Defense. Dr. Werren reviewed the current activities of the Civil Defense Program. He stated thdi the Netional Security ilesources Board have sent telegrams ts the Governors of d1 the states advising then t o plan their civil defcns;: progrpms, end that Federal agcncias will cooperate m a land aid relative to the trainirlg of personnel f o r the treatment of cftsualtics and from a It i s proposed th;t training courses be initiated by 'Athe AEC t o essist tho NSRB in its civil defense function . One course xi11 be for the tr dn hg of r sdio logic d monitoring ir struct or s md the other for the training of
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instructors in tho medic21 mpocts of atomic wxfze. ,After 2 full discussion of the program t h e Committee rei tore ted their previous views regmding Civil Eefcnse Pkmning by reaffirming their action as stated in the minutes of February 12, 19k9. of the Committee whether it was advisable t o make smsll grants for remodeling physical equipment i n connection with research contracts. Dr. Warren requested tho edvice It was the sense of the Committee t h a t each specific case would have to be judged on i t s merits and considered in divi dud ly. Radiation Tolorencos. Dr. ' & ~ r e nreported on the suggested levels of tolerulces. 10 for the worker within the plant adas de ty fe ctor of 100 for the large population outside the plant hsd boon the problem and a report will be mada at a later date. Deputy Djrector - Dr. John 2, Bowers. that Dr. John 2, Bowers, Deputy Director o f the Division, was transferring to the University of California a t Berkeley f o r invostigative work as of FebruPry 1, ISSO. ., Dr. Bowers w i l l assume the position of Special BssistPnt to He ste ted that am faty factor of Further studs.' is being mado of the Deputy Director Dr. Werren reported the Director, effective with the assumption of his work a t
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The Cornittea exprosaed their cornendations of D r . Bowers' past work with the Division of Biolcgy a d t h a t Xr. John A. Derry wzs joining the staff of the Division of Biology A d Medicine as Executtve Officcr for Biology and Medicine is scheduled t o be held i n Washingtcn on M3rch 10 and 11, 199. The next meeting of the Advisory Coziittbd