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€or liesearch and Development Programs, BER DE. Barr'@m e a of April. 9 makes it important to put on record what has bean dona 8h Ce his earlfer memu t o you of September 7 , 1973 on The fol lod ng are notes from my discust8ione with experts i n November 1973. The question addressed to them was wwZd it be scientifically important toget information on chrmoerwal aberrations induced by low chronic levels of Lrradiatgon such B P these people may be exposed t o when they return home. possible within reasonable lim lts to do a good study. whether this information would be medically uaeful t o the indigenous people was not discuso;ed. This ie a aepnrare concern and may be the most important: in determining whether any work of t h i e kind should Another question to then was would it be Logistics : 200 people, a t m y six per day would take two scientists about one month to do, Equipment : Small medical lab, two portable incubators, People: Perhaps at? person could do it, but two would bo much better. level, highly qualfffed. could do it. Need people of the technician Carolyn Gooch could do S l i d e Readinat More than one lab might do it: Shelly Wolff, Mike Bender, Brewen and Preston. liclstenbaum, of the Aratricaa Tobacco Institute would ba a good person to consult on experimental
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Rethod: ‘fhey would like to use their ovn techniques for as a teat population to work its out. 6 two t o five percent difference with age. variation i s indeed greater in older people, say in content of Dm for a specific chromosome. the they figured it would be about 18 mntha until their methods were ready for field etudies and t h a t would be Kay 1975. It is sensitive and They’d like t o use thi6 popdatfon They can see Blood could be collected in f i e l d and sent to Livermore, Chromosomes would be stained with uausl systms and also with bandlag methods. Semen sataplcs mafght ale0 be collected for atudy by Bert Gledhi21, reproductive biologist. It f s opparant that they see this 88 an opportunity to teat some of thelr s yet ew ; we should not uex the standard methodologiefi first or a t leaat. BENDER, John Nopkins This work should be done! studied before resettlement or Fnrmediatefy after be made and stored for examination later -- should be frozen, but very importent that they be kept dry. The people should be The slides could be made by somebody Perhaps fly blood to Hawaii; sltdes could A profeseionat ahuuld plan it and decfde w l m should do it. Csrrano is good. Petersen snd Deaven st LASL are good. Brewen and Preston are good. h study of somatic cell aberrations i5 a reasonebhi! thing to do. it might be obtained on these people. we need Low dose effects dala, end
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S m p l e the people, say e.round 50 to 75 frog; bikini end 100 from khawetok. Easy enaugh to 40, Bend blood Eantplrs to a l a b . &;illlast 33 t o 36 hrsurc, preferably not f.rra~:c?n but elighely cooled. ~ oul dbe good to have B boat, with lab aboard, incubator, medis, two centrifuges. Perhaps just separate white calls and hip them out. in Q. wedim vilf last 24 hwrs, with lsoX success. Piigttt: elso look at buccal smears for 1c a d Y chmosoFea1 aberrations; easy procedure and worth the additional effort. Zwa people in the field wu1.d do it, good t a read afew elfdes inSrfolfy to deternine how @any cells are needed, m d if back $ p ~ ~ r iio I'tia reading could be a caflaborotOve effort. A n oral s\snmary of these notes was gfven to dre. Canard ancl Barr about December 1973 when D r . Coamd was at Headqusxfews. hpressfon of his asaesmeat at the tfme W a c that there were tu0 many pol1r;ical problems and other issues imrolved with Chis resettlement t o undertake tests o f thia kind which ti'tcrcseelvee could raise problems. Geneticiot, Biomedical Programs Diviliion of Blaaedical and