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Health Sciences Research and Applications Branch Division of Biomedical and United States Atonic Energy The.folluwing paragraphs contain my re narks concerning the review of the AEC Health and Kort ali ty Study which was undertaken on 20 Sovenber by a group of consultants of which I was one. Se fore proceeGing, hwdever, I should lik ~t os zy that my ger.eral reaction was that tSe study is extremely important and should certainly be carried through to coq let ion despite high costs and obvious difficulties. from the long delay in initiating the project after the beginning of the Some of these, of course, stem ...... case, one of the problem is that the expected cozpiica:iocs of rac i ation appear advisable to include as many A X installations as possible in the study and I believe that the roster of Atomic Energy Cozzaission enployees being developed by Dr. Elancuso merits support. proposal t o add 6,000 t o 7,000 construction workers a t the Hanford installation is advisable.I believe that all ezmeratecl workers should be Included even Ciough the quality oE expcsurc in for zu tic n =cries cons ld ? r2bly. It is my understanding t5at .\;kerz q car icd civ c expc;snre data is zo ti vai iz ble,. I also believe that the
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i9 in various dosage groups, I believe it would be useful ta obtain infarction regarding exposure to ic port act intervening variables pei cula rly smoking by sample survey techniques on lin it ed subgroups. preferable to the present plans which do not call for ~TFJ ascertainment of such risk factors. I believe that the investigators should consider reorderf=ze the irc2r bai is on priorities giving a higher priority to util iz at ioc of g m - rllif2 tab12 data and in plant conpzrison be we en exyosure grou?s wSik d;rwn-,sadlr,q the comparisons kith sibling controls and mt ched controls fr ~ ms oc iai security should be included, Nevertheless,I think that the last t ~ oc on tro l pups are z sei ul acd Uith respect to matching the social security control grow,1 would suf " jst consideration of usicg fewer in it i zl mt ching character is r trs and c5tai ning be more useful than date of birzh or date oE issusnce of sacla1 c,eari:y recor2. Finally,I see no reason why the investigators should not ' seg into preFzre papers for submission to refereed journals. There woulc! seem to be atleast the Hanford S iS lina Study should be given current ex ? o s - a.In cid enz ally, ifthe paper inthe Proceedings of the Sixth Annual Hear- Physics So:iety ! ' i two methodological contributions vhich could already be =de acd I believe that