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Attachment No. 1 t o Factsheet Human Experimentation - 138 "&vnluatlon of Radiation Response by Means of Ex folia tl ve lowin Cases with Cancer of the Cervix Treated with Radiattonhis ctudy, active since fiscal year 1961, is designed t o help evaluate ex folia ti vec ~ tolog ya s a tool for de te mining prognos is in cases with car c in ma of the cervix treated with radi - ation. During 1964, an analysis of cases with B minimum of two years continued observation was made correlating the presence of tumor cells in the vaginal smear a t one month, two months, four months, six months, twelve months, and atthe end of radiation therapy with two-year,tumor-free survival. total of tvo hundred and forty - four cases were analyzed and the f oll wing information ott a in ed. cog niz able tumor cells in the vaginal smear tis long as one yeer after therapy even th qh the patient my be healed Of her disease at the end of two years. If the vaginal smear is free fran tun or cells twelve months after radiotherapy, the patient will be well at the end of two years in eighty percent of the cases. The presence of tm or cells in the vac in al mew a t the end of radiotherapy and one month aftexward has no relation - ship to prognosis.Patients who consistently shw positive mars for tumor cells after therapy will either die or suffer fr m persistent disease by the end of two years. Ma.ing the dl st ln ct lon between turnor cells and normal vaz in al epi the lim display in pronounced ra ii ation effect is very difficult in Sone cases may show re-