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Project Name: No formal Lr oj ect -name designation : Human Studies Date Started : May 1965 Date Terminated: January 1972 Objective(s1of Project : The determination of the metabolic fate of radio nuclides ingested or inhaled by humans i n good health, and calibration of both static and rotational scanning instruments for the direct in - vivo measurement at internally deposited radio nuclides. Short Description : Eight human volunteers were involved with the human studies endeavor, which consisted of thirteen individual experiments. A1 1of the eight persons invol ved were employed by the ID-AEC, and a1 1 were associated with the Analytical Chemistry Branch of the Health and Safety Division. Four ofthe experiments invol ved inhalation of Argon-41 (a noble gas witha ha1 f1ife of 1.8 hours) and nine experiments resulted in the volunteers swal 1 owing insoluble polyethylene capsules containing micro curie amounts of radioactivity. discussion of the guide1 ines and philosophy used during these experiments i s provided in Reference 1. below. methodologies uti1izing human volunteers from this human studies project. References 2-4 provide discussion of counting Follow - up Data : The short half life of Aro and its small residence time i n the body resulted in very smal 1radi a tio neodses to the volunteers. The insoluble capsules required about 24 hours t o pass through the body and produced very small doses due to the quantities of radioisotopes involved. As a consequence, no follow - u p data a quis it ion was considered necessary. 1. IDO-12058, "Some Guide1 in es for Studies Involving Internal Administration of Radioactive Materials to Human Volunteers," C.W. Si1 1, Heal t h and Safety 2. J.I. Anderson and D.G. Olsen, "A Rotational Technique for Assessing Quantity and Distribution of Body Radioactivity, " Heal t h Physics 13 (19671,
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3. D.G. Olson, 'A direct Calibration Using Gama Spectrometry for Measuring Radioactivity in Humans," Health Physics 14 (19681, pp. 439-447. the Location of Specific Nuclides in t h e Human Body," Health Physics 23