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FACTSHEET HUWN EXPERIMENTATION - 183 'j:g s 1 1 $ 0 i Project Name: Long-range effects of internal Date Started : 1950s emitters and other f oll ow-up studies - Date Tenni nated: present Identification : ACHR, FMI Objective(s) of Project : To gain in for mac elated to' the increased probabi 1ity of human exposure t o x-rays and to radioactive materials which followed the development of nuclear power, and information on the long-range effects of irradiation in man. study of more than 400 persons bearingShort Description : For 20 years,aj a considerable body burden of radium ("$a) was under way atthe Argonne Cancer Research Hospital and the Argonne National Laboratory. Most of these persons were painters of the radium dials on luminous watches at various plants in the I11 inoi s river Val 1 ey region during 1920-1930; others recei ved radium chl oride by injection or orally as a medicament between 1920 and 1933. considerable body burden of radium were found t o have characteristic defects, destructive changes, and tumors i n the skeleton. T h e Argonne Cancer Research Hospital-Argonne National Laboratory studies included accurate estimates of the body content of radium by gamma-ray spectrometry ina total-body counter and by analysis of the expired breath for the gas radon which is given off a s radium decays; by roentgenographic studies o f the entire skeleton ; and by studies on the blood which reveal whether destruction or malignant changes of the bone marrow are taking place.* (R.J.Has ter li k) Other follow-up studies performed a t the Argonne Cancer Research Hospital on individuals who had been irradiated prior to the e stab li shment of the Hospi ta1 had been exposed t o x-rays --i n utero during routine diagnostic pel vi me try examinations. This study, which extended over about 25 years fol lowing the b)Afol low-up study on patients who had received radiation therapy for stomach ulcers was funded,by DOE. The study i s now t o be resumed with support from NIH. Some positive findings had resulted from the DOE study. Persons who had received short cources of treatment with1 ow-vol tage x-rays for benign conditions about the head, neck, and upper thorax during childhood were studied in the early 1950s for possible development of carcinoma of the thyroid.
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A1 1of the chi 1 dren with carcinoma of the thyroid who had been treated or seen by the investigator (D. E. Clark) has been irradiation previously in such a way that the thyroid gland or portions of i t had been included i n the radiation field. *To our knowledge, studies on the radium cases are still being continued a t ANL. mal ignant tumors i n man. C.W. Mays etal.,University of Utah Press, Salt Lake City, 1969, pp. 195-225. In: Delayed Effects of Bone-Seeking Radionucl ides.