Development of Techniques and Methods for Medical Application and Environment Health Problems - Budget and Reporting Code Ha-02-07-01 (Partial)

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TITLE Development of Techniques and Methods f o r Medical Application and Environmental Health Problems ASSOCIATED UNIVERSITIES, INC. BROOKHAVEN NATIONAL LABORATORY BUDGET AND REPORTING CODE DATE PREPARED 1.8 pg/g Cd i n the liver and 1.5 mg Cd for one kidney. mounted ina 34 ft.trailer which, complete with medical examination facilities, can be moved t o any site to study industrially exposed populations. The facility has been The measurement of total bddy nitrogen by prompt gamma neutron activation was first originated by Rundo of H amell. developed by the University of Birmingham, England group. A t BNL, neutrons from 238Pu,Be o r 252Cf "portable" sources are used i n place of the cyclotron neutrons used by the Birmingham group. In recent years, the technique was further The feasibility of measuring Liver burdens of cadmium in vivo was first preThey use a pulsed beam of cycl-sented by Harvey etal.in Lancet, June 7 , 1975. otron neutrons, while the BM, system employs "portable" aources of 238Pu,Be or surement o f both nitrogen and cadmium, such as ease of operation and the pos sibi l - ity of locating the facility in a clinical environment. precision and lower radiation dose t o the subject is possible with this technique. Further, the portable nature of the 238Pu,Be and 252Cf sources permits the use o f mobile activation facilities that can be brought t o the population of interest easThere are numerous advantages t o the use of "portable" sources for the meaThe work is conducted as described in sections ~ OC., 20d., and 20f., and i s i n conformance with generally accepted methodology for investigations of this Fiscal control will be exercised in the form of monthly comparisons, over the task term, of actual costs incurred against corresponding line items of the budget. Technical results shall be monitored through a periodic review, by the Contractor Task Manager, of accomplishments by measuring actual performance a s compared t o expected progress. All work shall be conducted i n conformance with generally accepted standards for R&D and other investigative or analytic procedures, a s observed by universities and large independent research facilities including Brookhaven National Laboratory.