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Radiation and liu!.un Sperrnatojeneris Seattle, Washington Deceiilber 2-3, 1955 (1) To have a penetrating in-progress research progrm revir:w before qualified reviewers and AEC adtninistretive persorinel i n advance of termination of any aspect of the Hellcrt o repeat o r extend the hwan spermatogenesis type of w:>rk probably will not occur again soon, and that every effort should be made t o assure project objectives. To have sharp scientific discussions devoted t o Sertinenr; invited to make pertinent comments based on their own studies and experiences. Michael Bendee, Oak Ridge Notional Laboratory David Berliner, University of Utah George Casarett, University of Rochester Kenneth Cooper, Dartmouth Medical School Lloyd Hopwood, Colorado State University Eugene Oakberg, O a k Ridge National Laboratory Emil Steinberger, Albert Einscein Medical Center, Pniladelphia Suggested Program Discussion Areas I 1. Status of Research Programs--Drs. Heller and Paulscn, ard conditions of irradiation and tirdng, i?,cludir:g thep ~ ~ bleu, of quuntitation itself.
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( b ) Seminal. Fluid Barniristion: Carrelstion of t h e conditions of seminal fh idw it n zhe histopttk?l;gica-L conditions of different t c s tictila- tissue elements, tu?. L:Ig effectiveness of hemocytomter and Ccmlter count.er :>rdcedurcs f o r sperm countinc. ( c ) Urine Analyses : Relationship of gonadotropin outpdt and degree of tubule denuding. (d) Lcydie and Sertoli Cell Effects: Radiasensitivity conDared with that of germinal tissues; Sert ali cel.2. fw c tio ti 'and how t h i s nlay be-.altered by irradiation. ' (c) Rhythms, Homeostasis : The relative vulnerability 0; cells at different stages i n the mitotic cycle with respect t o irradiation; ni to tic delays or blocks; alteration of maturation sequence patterns and of ccll inaintenance levels; modification of feedback factors tending to fix testis size and rate of spem, output. ( f ) Chromosome Alterations : Frequency and character of aberrations, and the stages a t which such are most readily induced during the mitotic cycle. ( e ) Residual Capability: The functional capacity of i r r a - diated but unkilled cells with respect t o proliferation, maturation, fert i liz ability, efl'ects on the einbryo, etc. ( h ) Recweq: The extent t o which Geminal and other tir;sueo divest themselves of weakened or dmaged cells--also the extent t o which damaged cells ';exid t o replicate relative t o undamaged cells ; restoration of norr:d. houeostatic balances with respect t3 numbers of cells, size of organs, spxm output rate; escsblishnont of timr on t h e respoiaes of sgerclatogo9ia ai6 other cells t~
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sperm morphology, and concentration follow in g' ionizing ' .- b. Rowley and Ka stella a. Hall ing and Paulsen Urinary estrogen s as an index of Ley dig - cell function a. e levels following x - ra diz tion, ' Lunch (no hosc) Ncrwescern Room mozphology; clinical changes f oll wing,
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Our format is to invite the advisors t o break up into four Following the workshop, a member of the advisor ls group and a member of our laboratory should be prepared to give a 10-20 minute summary of uhe workshop session and to give their suggestions for future plans, and Nestor Cachiero) Hormones Dr. Donald Brusca ' 1. Swnmary and future plans of workshop sessions. 2. Future plans of program as a whole.