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LAWRENCE LIVERMORE t4AT IONAL LABORATORY Operational Safety Procedure HUMAN SUBJECT EXPERIMENTS lITH The Laboratory's basic safety policy i s t h a t operations must be planned and conducted in a manner that will prevent injury t o personnel or damage t o accident-free work environment for the human subject experiments with air tagged with radioisotopes iil Building 194 are stated in the Operational Safety The minimum safety rules and practices necessary for achieving an Everyone 1n this building,i ,e., visit on, mai ntenance and service employee, and regularly assigned erqloyee, i s required t o abide by this procedure and the LLNL Hea?th & Safety F:lanuai t o protect himself and cjther personnel from injury. t o uwk;stznd the safety regulations relating to what they are doing and t o abide by the safety requirements. T h i s procedure was prepared by building managemnt assisted by Hazards Control. Confer with the Hazards Control safety team assigned t o t h i s bgilding for interpretation of this procedure and for planning your operations t o comply with safety requi renents. Each individual in this bui lding shall use this guidance effect i vely t o avoi d i nj u ry , This Operational Safety Procedure has been reviewed by:
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Operational Safety Procedure HUMAN SUBJECT EXPERII4ENTS WITH The purpose of this study is to measure the rate of nitrogen and Argon uptake and elimination in the body o f normal healthy humans. more than 120 minutes. .Any required change in operations that - alters the scope .or significantly decreases safety control will not be made until a revision or supplement to this procedure has been signed by the person authorized to approve this OSP. Any required change in operations that does not decrease the safety control may be made with the joint concurrence of the LINAC Operations i4anager and t h ? Hazards Control Safety Tean; Leader. 1,This procedure authorizes the exposure of human subjects to the a) Breathing of air tagged with I3N and 41Ar for up t o 120 minutes with an accompanying dose of approximately 400 &em tothe participants. See attached letter from the Human Subjects
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.' Operational Safety Procedure Estimates of the radiation dose from 13N and 41Ar activities in the breathing mixture are based on calculations ' by Hazards Control ' s Health Physics Group (see letter from K. Shingle ton of April 12, 1982). The forai20 minute experiment and for 41Ar i s approximately 6400 &em for The actual maximum dose to participants can be calculated as follows : The breathing gas concent rati ons w i 11 be: Time elapsed from beam shut - off to administration will be - 20 minutes. With this in mind we then obtain the est in at es at t=20 min. for 120 minute exposure. minimizing the presence of 02 in the nitrogen. Some trace of O2 always is present and in this ionizing The concentration is controlled by The Operational Controls in paragraph Fwill reduce the above hazards i o
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Operational Safety Procedure Paul Meyer i s responsible for assuring that all work i s performed i n conformance with this OSP and the LLfL Health & Safety ilanual. absence, the experiment wi 7 1 be termi nated and a responsible person wi 11 be trained for the experiment. A 1 1 participating employees are responslble f o r performing thei r 'work according t o the regulations of this OSP. They are expected to take all reasonable precautions t o protect themselves and their fellow employees and t o perform only those tasks t h a t they believe can be accomplished safely. Wh2n participants have any d o u b t regarding the safety cf any supervisor before proceeding. The Hazards Control Safety Team assists managiment to institute and t o mai ntai n a 1ox-ri sk work envi ronnent .In addi t i on, Hazards Control may request that management or employees stop a n operati on when there appears t o be an imminent. danger t o personnel o r property (see Health 8 Safety Manual Section 1.06). 1. The target gases are: a) Ar: Zero grade Argon b) N2: High purity nitrogen (silver colored bottles with pink top).
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Operational Safety Procedure 2 . Waste gas disposal i s achieved with large volune blower which pumps gas from the site of the experiment t o the outside o f Bldg. 194 atthe roof All human subjects shall receive a whole body radiation scan by Hazards Control before and after inhalation o f radioactive gases. The radioactive gases shall be filtered with a HEPA filter before inhalation by the subjects. gaskets and canister will be made prior to filter installation. approved and tested f i 1t e r cartridge obtai ned from Hazards Control Respirator Branch will be installed in the filter canister. A visual inspection of the filter cartridge Radi oacti ve gas preparati on: The evacuated target gas bottle, located i n the 0' cave, is filled from a standard gas cylinder containing either high-purity nitrogen (N2) o r Zero grade Ar. Upon filling, the gas i s being irradiated by LINAC I n the case of N2 as target g a s , any undesired by-products come from small oxyger: concentrations in the gas bottle. This can lead,in principle, t o NO2 and NzO. Tests performed previously by Hazards Control personnel, found concentrations of less t h a n 1 ppn of 1402 and less than 22 ppm o f N20 in an irradiated sample. will be tested for NO2 and ozone before i t is administered. The breathing mixture a ) Evacuate target-gas bottle t o < 53 microns.
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Operational Safety Procedure c) Bleed radioactive gas as described below, into plastic bag. Human subjects will n o t be exposed t o concentrations of NO2 > 3ppm f ) Navy personnel will continuously monitor and hold 02 concentration irie prepared an;;. tested 92s mix tur c is takert f ~ mTr?!’!er 930 t:, the subject in Bldg. 194 in a plastic bag whi.ch is then connected t o the breathing valve. The subject then breathes f o r 120 minutes from the bag. The exhaled gas i s passed through a soda lime trap to remove all Co2 before returning t o the bag. maintained i n the bag and monitored with a bio-marine oxygen deficiency meter or equivalent during use by Navy personnel. minute period the bag i s disconnected and the subject breathes room a i r with the washout being vented t o the outside of Bl d g. 194. A t the end o f the 120 1
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Operational Safety Procedure Fire Safety Div. HAZAKDS CONTROL: W, L, Enei d i