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cornpncnt of ambient air pollution where atmospheric photochemical and several of its effects have been defined, although the damage mechanism is still uncertain. The importance of Ozone (0,) as a toxicant is recognized The objective of this proposal is t o describe the early effects of low concentration of ozone (0,) on pulmonary function in anesthetized, mechanically ventilated dogs. Inthe first, standard functional measurwnents of dynamic lung response such as pulmonary flow resistance, mde both during resting ventilation and hyperpnea,the latter t o simulate There will be two parts to the study. will be made. Exposures will be In the second part, regioncil ventilation,diffusion and the sites of The regional dnd stadd functional data will then be compared t o determine the sequence and possible inter - relation of early functional changes from the ozone. R, Yodar, who was head of Ila/,ards Contr.c)l I n t i 1 receni ly, siw sorne interesting applications of a positron camera (which was beint built at the Linac as a general purpose y - sc in til ation detector)to his field of
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and nma professor atthe School of Public Health and cormunity Mediche of the University of Washington in Seattle initiated a cooperative effort t o study the effects of ozone on the respiratory system. urging the Linac group has investigated the possibility of tagging ozone with an 150-is0t0pe and visualizing with the positron camera the d is tri - bution of radioactive ozone and other positron emitting isotopes (13N, at the Linac in late 1 9 7 1 and early'1972, R. Frank and his group came t o He and R. Frank, M.D., a former associate of his at Harvard Livermore atthe end of November, 1972, t o test the Nitrogen and Ozone techniques on two live dogs. Results indicated the feasibility of the method. The software associated with digital data was tested and found t o be functional. Isometric (i.e. three-dimensional) displays illustrated unaml;i,uously the local uptake of the ozone in the upper pulmonary region for low ozone concentration. 3.. E'rank suggested a Ph.D. research program for one of his graduate students. R . YOder's interest stemned from a direct benefit tothe Hazards Control Department program from such a
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The University of Washington is preparing a research grant request t o the National Institutes of Health. LLL's funding request for the work t o be performed as outlined in the proposal is as follows: Travel (2trips to Seattle) Travel ( 2 trips to Seattle) Travel (2trips to Seattle) Study t h e effects of NO2 and SO:, on dogs and expand the ozone studies