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Ozone has been identified as an industrial hazard and significant component of ambient air pollution where atmospheric photochemicdl and several of its effects have been defined, although the damage mechanism is still uncertain. The importance of Ozone ( 0 3 ) as a toxican% is recognized The objective of this proposal is to describe the early effects of low concentration of ozone (03)on pulmonary function in anesthetized, mechanically ventilated dogs. In the first, standard functional measurements of dynamic lung response such as pulmnary flow resistance, m d e both during resting ventilation andhyperpnea,the latter to simulate There will be two parts to the study. will be rrade. Exposures will be In the second part, regional ventilation, diffusion and the sites of 150-tagged ozone uptake will be studied using the bilateral positron camera at the Bldg. 194 Linac. The regional and standard functional data will then be compared to determine the sequence and possible interrelation of early functional changes from the ozone. R. Yoder, who was head of hzards Control until recently, saw some interesting applications of a positron camera (which was being built at the Linac as a general purpose y-scintihtion detector) to his field of
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interest. He and R. Frank, M.D., a former associate of his at Harvard and now a professor at the School of public Health and Corrununity Medicine of the University of Washington in Seattle initiated a cooperative effort to study the effects of ozone on the respiratory system. urging the Linac group has investigated the possibility of tagging ozone with an 150-isotope and visualizing with the positron camera the distribution of radioactive ozone and other posibmn emitting isotopes ( l 3 N , "C) in the respiratory system of dogs. After some preliminary 03-experiments at the Linac in late 1971 and early 1972, R. Frank and his group came to Livemore at the end of November, 1972, to test the Nitrogen and Ozone techniques on two live dogs. Results indicated the feasibility of the to be functional. di guo us ly the local uptake of the ozone in the upper puln-onary region for l o w ozone concentration. 3.. Frank suggested a Ph.D. research program for one of his graduate students. direct benefit to the Hazards Control Department program f r o m such a The software associated with digital data was tested and found
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The University of Washington is preparing a research grant request t o the National Institutes of Health. LLL's funding request for the work t o be performed as outlined in the proposal is as follows: Travel (2 trips to Seattle) Travel (2 trips to Seattle) S t u d y the effects of NO 2 and SO2 on dogs and expand the ozone studies