Document text
Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
Page 1
3 * Contractor - Laboratcry 4. Working Location 5 3 Contract No. Univ?rsi+,y of Cslif ormia, 1701 dtar 10, Person inch G gem - ect or fs staff) the his to path d ~ gizn lznd fm c tic nal challges inthe thyroid induced by small 11. Status(Inch ding ster ting dab) 14. and 15G Acconpllshxa-Ls Last Year and Expected H e s u l k s This Year * guinea pigs and ~rcnkegs. pssess suf fir is ntl yl.o q half - Eves to permit investigative work ~ able time, effort dnd energy went into devising an appropriate procedure for producing the necessary astatine, It i s convenient t o divide the program into the fol - 1; Fr qx ration 2nd Assay. There are two isotopes of astatine which 2, Tracer Stwii.es, Tracer studies were performed with groups cf 5 ' 3 , Radioaxtcgra;)hic studies, Special interest was given t o detemiiie where the astatLne Wa:: h cali zed in thyroid tissue, the radLOb?GlcgiCal action of astatine in the rat a$ varicus dose levels,for not only the thyroid hut the other tissues and organs, as well. groups of 5 recsfLved dosages o f 10, 50, 70, 100 and 150 J.K. t o investigate the possibility of internal irradiation Q € retention CYS-LS. It ap?eared tha-t a st stir,e night be an ideal choice in view of its short half - life and range char xL eris tics. injury tothe various structures of them teri or charrber of the lens. 4 , Radiobiological Studies. These studies were designed to ascertain 5 , In cooperatLon with the Nedical School, this e>Teriment was designed Rhesus monkeys were used t o provoke visible It i s planned t o extend these studies of the histopethological and fun c tim al changes of ths thyroid using monkeys. studies may be perfomed if t h e y can be acccrn?liehed completely devoid of any It also appears that human-c it ted to Divisi.on (2 f Biology and Medicine.
Page 2
Op rating Gests 18, Plant a2d Eqcipaent Costs -_I_---19. Direct Xq2&==2ars) lha G: Ihn No, of Ean No, of Man Years Yezrs Years 20, Actual costs prior t.cj last FY 21, Estka-Led to;al costs of project