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BEST COPY AVAILABLE 1. A study of patietits with,'#yroid cancer treated with radioactive iodine, The abflity of uortain morphologic type6 of thyroid&maer to ooncentqte iodine provides a unique opportunity to determine the possihle usePulnem of radioactim isotope therapy by applying radiation loo ally to It ha6 been found fhat certain thyroid .cancers are aapable of oonaentrating radioactive iodine in amuunta adeqxaate to rsuppfy a t $ e.raA peutio doeage of radiation to me;taststia deposits8without demonstrable eancer which fail to concentrate adequate $laoun t of radioactive i o d h s can of'ten be induaed to increase their Iodine uptake to a degree permitting thiouracil or thyroid stimulating hornone, and temporary alteration of renal function to decrease urinary loss of radioactive iodine. Other mrphologic types of thproid Theae meatium8 uonsist of thgroidsctorrry, administration of A major aspect of this rrtudy is to determine t h e degree of damage to be expected in the tm or tissue from varying amounts of focal radiation. equal importance is the evaluation af the effects of radiation on norxd. tissues incidentally expoaed in the couree of treatment. significance in this regard are the effects an t h e hematopoietic system, the endocrine tieslues, t h e gastrorinteartinal traot and l&e kidney. Since these studies frequently require prolonged observation i n the. I hospital, ~patlypatients are n o w required to vait for sospital space before their diagnootio and therapgpejo proeeciurss oaa be undertaken. fire effort betwear8Faa4u+sll OiaUmd. Leboratorlea and Memorial Rospital greater aLzaPbsr of patients. The
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Henorhd. Hospital had available f o r study about 70 patients with thymid waiting for adraission. In 1949 it is expected that t ne nuiiber & odd exA t the ?resent t h e 22 patients with tSy,-oid neoplasms are Of these it is believed t2at at least five have A prop m could be errtablished wnich would permit %ne a his sf on t0 MenorLa3,- iiospital of a sttaady flow of patients wit:] thyroid ttincrs, their primary sedical work up, screening for I13I uptake a d the institution of nece88ary rnea8ure6 of standard surgical o r otser txmapy. be roxhd to Brooklzsven for prolongea hospital is ation, 8erve a6 useful study and instructional material for the ataff under There they might developmerit. When requires, they could be returned to Memorial Hos pi W for special procedures not at present avdlable at Brookhaven. The Memorial fi ospital will be glad to recornend the Erockhaven medical staff for faculty appointments at Corn dl University Medical College and on itsom staff. tr as far patients with other types cf cancer t o broobaven for such investigative procedures as m y be agreed upon as wise and pot ect i ally It will provide fort9e tirookhaven group full integraIt will be prepared to Facilities are immediately available at Memorid Hos?ital f o r the treatment and study of patients accidentally or intentionally exposed to large mounts of radiation. In the event of exposure of individuals to massive amount8 of radiation fron radioactive materials, the following diagnostic ant! therapeutic pro-
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A. Berapeutic measures including special dietary, chemotherapeutic I. Hemoglobin and cellular changes in the peripheral blood and EStcretion of porphyrhs and b i l e pigmnte in uriw and feces, Observations on the rate of hemoglobin formation with the use of glycine labelled with $5 and w i t h the U68 of isotopic Fe, 1. Nitrogen and electrolyte belance st~diesi nc lud iq calcium, phosphorus, sodium, potassium, chloride and magnesium with con2, Determination of the acid-base balance and alterations in blood Deterntination of plasm voluxe, extracellular fluid space and total bey water. Deternlination of titwue electrolyte patterns fmo? biopsy material. Fiend and hepatic funation studies. P. Evaluation of endocrine disturbances. 1. Determination of total urinary 17 ketosteroids and reducing steroids, and pituitary gonadotrophis assays. Identification of the urinary ateroid pattern. Determdnation of serum protein-bound iodine, basal metabolic rate, and radioactive iodine activity. 4. Glu<ro,seand insulin tolerance curves, E. Determination of residual radiation.
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Facilities are available for stuciyirig excreta end tissue biopsy material f o r the preesnce of radioactive Sub8tanCe6 either hduced or introduced at the the ~f the accident. _ - Spectroscopic studies of the patterns of elements i n blood, cells, plasma, and tissues. Microscopic studies of tissues. Studies of nucleic acid metabolism. The iiospitrd now admits 6200 pti ents, does-5502 operations, most.ly very extensive, g i v e s 70,003 x-ray treatxents, sees 20,030 patnological specimens of timors end fi&~c?leS11'3,306 out - pti ents. These activities shoiilc! increhse b;r ,5Cl% vit!i the copipletiou of the Lving doe Fit al in the fall