Document text
Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
Page 1
h t 1an ti! Do c urn en t s "Medical Experimental Program on Ra & Pull The following data are urgently needed. outline of ongoing research,mostly in rats. c.Tracer experiments in humans -- ratios of blood level to urine & ' fecal excretion following intravenous injection of Pu (Bale, Hempelmann, I lee ting in Chicago Dec. 4 & 5with all involved to plan 1 / 1 9 / 4 5 Memo to Files / Friedel l Animal Metabolism Studies & Data (rat) In conjunction with the experimenG.1 conducted in animals ,I 1 it is expected that on selected human subjects tracer studies with Pu would b e made. The purpose of this would be to establish a relationship between the amount excreted and the amount retained in the body. This could serve as an excellent monitoring index to determine hazards to personnel.This is of course predicated on the idea that some conclusion as to the tolerance level of Pu inthe body will be established from the experimental outlined above .I1 Attendance - as suggested by previous memos Nos. 18 & 2 1 - Friedel l,Bale,Cole, Warren, Hempelmann, Ma stick (Los Shipment of 5 mg Pu, detailed instructions for preparing solution,injection,collection and shipment of excreta (written after administration of Pu by Friedel l) see Eo.43 With still more explicit instructions than above Encloses protocol (as i n No. 41) " Everything went very smoothly"". . .I think we will have access to considerable clinical material here and we hope t o do a number of
Page 2
REPOSITORY: OFFICE OF HUMAN RADIATION COLLECT ION : PLUTONIUM INJECTION INVESTIGATION FOLDER: PLUTONIUM INJECTIONS - CHICAGO
Page 3
No date,but references to letters arid conversations Points under debate : a . Number of patients on which to use prod ucc d.Factors related to absorption from skin between urinary and stool excretion(reference to Chicago and Oak Ridge patients) f.Distribution of Pu in tissues of humans should be carried out in moribund patients or patients dying from malignancy particularly Hodgkin ' s & leukemia Proposed experimental progrsm Injection of 0.06 mg/kg into LO patients with blood and Follow-up levels in blood,urine,stools for up t o Biopsies of bone if possible Tissue distribution in moribund patient Skin excretions with 238-239. urine status normal forage. levelling off state which occurs within8 wks-2 mo. Memo Howland t o Area Engineer,Berkeley Re: Hamilton ' s concern that " experimental subject " may move out of area unless some compensation b e made tohim. R e : concern about informing public about radiation hazards t o MED workers :::JJ a panes e Proposed Health Program for FY 46 (outline) mentions injection experiments,including tracer studies in humans using 48 Report of meeting in Rochester (by Langham) Detailed plan for Pu tracer study Revised plan resulting from meeting No mention of informing patient
Page 4
Ltr.Gold ring to Langham Enclosing clinical history of E.C. Clinical summary " Ex per in ent I on P49S?+ I ' Draft report by Gold ring to Ferry,Dist.Engineer, OK Bio logic & Health Physics Section "I t Summary of all research activities at various labs & mention of human studies Summary of work 15 Oct 42 to1April 46 & projected work t o end of FY 47 Comparisons of Pu retention and excretion in rodents and man discussed (based on data from a " relatively samples including bone) 5/14/57-1.7 Memo to Files by F idler,Chief, Tech. Info.,Field Op. Policy on Medical Reports only those experiments where actual materials wereI 1 intentionally introduced into the human system need t o be regarded as secret " Memo Nichols to Area Engineer,Berkeley Reference to progress report containing statement about intravenous injection of humans with certain radioactive substances "recommends against work on humans but also denies authority for such work under terms of Manhattan Memo Brundage t o Cooney (Med. Dir., Manhattan Proj., D.C.) Covering letter for Nichols memo " Visit of Col. Cooney to Berkeley Area" Proposed human studies discussed with Joe Hamilton. Cooney appeared to believe these would be satisfactory to AEC but Col. made no firm statements about: gov ' t support - - matter to be discuss cd at meeting in L!ashington on medical programs
Page 5
Ltr. from Friedel l to Maj. Clarkson, AEC, OR don ' t remember man's name who received some of t h e1 1 material -- there are records in the files -- "Joe Howland actually gave the material and h e might Ltr.Carroll Wilson, (21, AEC t o Warren R e Opinion of Interim I led ical Advisory Committee on Clinical Testing - - legal department to investigate responsibility of AEC " All Area Managers will be notified about contents ' ' Opinions of Commission r e approved clinical testing a.treatment to be given only when there is expectation b.decision of advisability to be made by attending Same procedure to be followed as agreed upon early March-- " susceptible to proof from official records that,prior to treatment, each individual patient,being in an under - standing state of mind, was clearly informed of the nature of the treatment and its possible effects, and expressed his willingness to receive the treatment...I ' no written release required but2doctors to certify in writing (and made part of official record)to patient ' s understanding state of mind of explanation furnished and willingness to participate. that it will benefit patient