Assessment, Evaluation and Control of Radiation Exposure to Man and His Environment - Exposure to External and Internal Radiation

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BIOLOGY AND MEDICINE 8 , RELATED WORK (With Same Contractor or Others) Assessment, Evaluation and Control of Radiation Exposure to Man and His Environment - Exposure to External and Internal Radiation ANL 63100 through 63300 Summary (BIM, RPY) '. BUDGET ACTIVITY NO. I. MANPOWER AND COST DATA ESTIMATED FOR FISCAL YEARS FY Con tinuine: 60. DIRECT MANPOWER ( M a n Years) TEMPORARY PAID BY OTHERS 0.4 TEMPORARY PAID BY ANL - BUDGET REQUl REMENTS FY 1973 TEMPORARY PAID BY ANL TEMPORARY PAID BY OTHERS 1.8 2.5 - 2.2 TOTAL MAN YEARS 36.6 39.3 - 41.8 TOTAL OTHER TECHNICAL MATERIALS AND SERVICES 269 479 - 513 63100 Metabolism and Toxicity of Fission Products in 63200 Radioactive and Trace

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REPOSITORY: OFFICE OF HUMAN RADIATION PLUTONIUM INJECTION INVESTIGATION EXTRA COPIES FROM ROCHESTER FILES

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06-02-0 1 Exposure to External and Internal Radiation $1,539 $1,748 $ 30 $1,888 Effects of Radiation 269 266 - 2 50 -04 Land and Fresh Water -08 Radiological and Health 06-02-01 Exposure to External and -08 Radiological and Health See individual 189's for detail. 06-02-01 Exposure to External and Effects of Radiation 2 4 - 6 -04 Land and Fresh Water -08 Radiological and Health S e e individual 189's for detail. See individual summaries, 06-02-01, 06-02-02, 06-02-04, 06-02-

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See individual 189's for detail. 63100 Metabolism and Toxicity of 63200 Radioactive and Trace See individual 189's f o r detail. Metabolism and Toxicity of Fission Products in Dogs. The ultimate aim of r e - search in this area is to establish the effects of raw fission product mixtures in biological systems which can be related to man. Dogs have been injected with '%e, 137Cs,and 1311, and effects are being observed. Three years ago, continuou exposure of dogs to 6oCo y rays was begun s o that the response of the beagle to to protracted, uniform, whole body irradiation at various exposure rates and total doses could b e determined. Internally deposited radionuclides a r e nonEniformly deposited and it is difficult to determine meaningful radiation d o s e s and the relationship of specific biological changes to the d o s e s . With external radiation, however, the dosimetry is more precise and the doses responsible for biological changes, such as tumor induction, can be more realistically determined. The comparison of biological effects of protracted, uniform, whole -body irradiation to the effects of internally deposited radionuclides will allow a n interpretation of the relative effects of total dose and dose rate.For this reason, emphasis over the next year or two will be on external 'OCo gamma exposures. Total effort will be reduced further over the next tear. Radioactive and Trace Element Metabolism. This activity in the Radiological Physics Division will continue in the general field of radioactive and trace ele - m e n t s in man. Almost without exception, personnel in this activity devote a fraction of their time to this aspect of their work, and the remainder to the Radium Studies. This is natural,forin many respects it is difficult to separate the effort applied to the programmatic aspects of theRadium Studies from the related efforts to generalize on the problems of localization, identification, and evaluation of the toxicity of internal emitters in man. Radium Studies. This program in the Radiological Physics Division has been organized as the Center f o r Human Radiobiology to study the long-term effects

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of radium and other internal emitters in man. It includes specific responsibility for locating humans with significant body burdens of radium, evaluating radiation doses, and accumulating pertinent medical data during their entire life spans. Responsibility for radium cases located and studied by the Radiation Center of MIT, the ANL-Argonne Cancer Research Hospital project and the New Jersey Radium Program have been transferred to this Center. The final program to be set up around these radium cases will include medical and physical studies on the living cases,a search for new cases, acquisition and study of autopsy material and willed bodies, exhumations and epidemiology. It is hoped that t h e s e studies will eventually include many other bone -seeking isotopes in man. A field office in Orange, New Jersey, maintains contact with radium cases and searches for new cases along the east coast of the United States. A satellite laboratory is operated i n Cambridge, Mass., under a subcontract with MIT. This laboratory is equipped to make whole body radium measurements and radon breath measurements on the patients in this area. Medical examinations, including X - rays,are made on the patients under study by cooperating physicians in the area. At the end of F Y 1971 this laboratory was making measurements on three patients per week, which is its maximum case load. The case records from the former New Jersey Radium Research Project, the MIT Radiation Laboratory, and (with only a few exceptions) the ANL-ACRH Radium Studies have been copied and a r e in the possession of the Center f o r Human Radiobiology. Within this collection of over 2000 cases, we have identifiec more than 800 cases whose body contents have been measured,some 600 of whom are still alive. An urgent need for a medical staff within the Center for Human Radiobiology has now been m e t . The Health Division of the Argonne National Laboratory, under the direction of Dr.Francis W. Strehl, has agreed to perform the necessary physical examinations on the patients who come to the Argonne site.Further, the need for in-house medical advice and evaluation of the records will be met by Dr. Austin Brues who will join the Center in F Y 1972.